Rheumatoid arthritis decreases risk for Parkinson’s disease: a Mendelian randomization study

Abstract Epidemiological and clinical studies have suggested comorbidity between rheumatoid arthritis and Parkinson’s disease (PD), but whether there exists a causal association and the effect direction of rheumatoid arthritis on PD is controversial and elusive. To evaluate the causal relationship,...

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Main Authors:	ChunYu Li, RuWei Ou, HuiFang Shang
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Neurology. Diseases of the nervous system RC346-429
Online Access:	https://doaj.org/article/57aef3ef33604911aef4dbae30d63557
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spelling	oai:doaj.org-article:57aef3ef33604911aef4dbae30d635572021-12-02T13:33:52ZRheumatoid arthritis decreases risk for Parkinson’s disease: a Mendelian randomization study10.1038/s41531-021-00166-x2373-8057https://doaj.org/article/57aef3ef33604911aef4dbae30d635572021-03-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00166-xhttps://doaj.org/toc/2373-8057Abstract Epidemiological and clinical studies have suggested comorbidity between rheumatoid arthritis and Parkinson’s disease (PD), but whether there exists a causal association and the effect direction of rheumatoid arthritis on PD is controversial and elusive. To evaluate the causal relationship, we first estimated the genetic correlation between rheumatoid arthritis and PD, and then performed a two-sample Mendelian randomization analysis based on summary statistics from large genome-wide association studies of rheumatoid arthritis (N = 47,580) and PD (N = 482,703). We identified negative and significant correlation between rheumatoid arthritis and PD (genetic correlation: −0.10, P = 0.0033). Meanwhile, one standard deviation increase in rheumatoid arthritis risk was associated with a lower risk of PD (OR: 0.904, 95% CI: 0.866–0.943, P: 2.95E–06). The result was robust under all sensitivity analyses. Our results provide evidence supporting a protective role of rheumatoid arthritis on PD. A deeper understanding of the inflammation and immune response is likely to elucidate the potential pathogenesis of PD and identify therapeutic targets for PD.ChunYu LiRuWei OuHuiFang ShangNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 ChunYu Li RuWei Ou HuiFang Shang Rheumatoid arthritis decreases risk for Parkinson’s disease: a Mendelian randomization study
description	Abstract Epidemiological and clinical studies have suggested comorbidity between rheumatoid arthritis and Parkinson’s disease (PD), but whether there exists a causal association and the effect direction of rheumatoid arthritis on PD is controversial and elusive. To evaluate the causal relationship, we first estimated the genetic correlation between rheumatoid arthritis and PD, and then performed a two-sample Mendelian randomization analysis based on summary statistics from large genome-wide association studies of rheumatoid arthritis (N = 47,580) and PD (N = 482,703). We identified negative and significant correlation between rheumatoid arthritis and PD (genetic correlation: −0.10, P = 0.0033). Meanwhile, one standard deviation increase in rheumatoid arthritis risk was associated with a lower risk of PD (OR: 0.904, 95% CI: 0.866–0.943, P: 2.95E–06). The result was robust under all sensitivity analyses. Our results provide evidence supporting a protective role of rheumatoid arthritis on PD. A deeper understanding of the inflammation and immune response is likely to elucidate the potential pathogenesis of PD and identify therapeutic targets for PD.
format	article
author	ChunYu Li RuWei Ou HuiFang Shang
author_facet	ChunYu Li RuWei Ou HuiFang Shang
author_sort	ChunYu Li
title	Rheumatoid arthritis decreases risk for Parkinson’s disease: a Mendelian randomization study
title_short	Rheumatoid arthritis decreases risk for Parkinson’s disease: a Mendelian randomization study
title_full	Rheumatoid arthritis decreases risk for Parkinson’s disease: a Mendelian randomization study
title_fullStr	Rheumatoid arthritis decreases risk for Parkinson’s disease: a Mendelian randomization study
title_full_unstemmed	Rheumatoid arthritis decreases risk for Parkinson’s disease: a Mendelian randomization study
title_sort	rheumatoid arthritis decreases risk for parkinson’s disease: a mendelian randomization study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/57aef3ef33604911aef4dbae30d63557
work_keys_str_mv	AT chunyuli rheumatoidarthritisdecreasesriskforparkinsonsdiseaseamendelianrandomizationstudy AT ruweiou rheumatoidarthritisdecreasesriskforparkinsonsdiseaseamendelianrandomizationstudy AT huifangshang rheumatoidarthritisdecreasesriskforparkinsonsdiseaseamendelianrandomizationstudy
_version_	1718392794946469888

Rheumatoid arthritis decreases risk for Parkinson’s disease: a Mendelian randomization study

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