Quantitative magnetic resonance imaging biomarkers in oncological clinical trials: Current techniques and standardization challenges

Radiological imaging plays an important role in oncological trials to provide imaging biomarkers for disease staging, stratifying patients, defining dose setting, and evaluating the safety and efficacy of new candidate drugs and innovative treatment. This paper reviews the techniques of most commonl...

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Autores principales:	Jie Deng, Yi Wang
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2017
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/57b5325a19b3403a9a7dc989c0342e58
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spelling	oai:doaj.org-article:57b5325a19b3403a9a7dc989c0342e582021-12-02T13:39:51ZQuantitative magnetic resonance imaging biomarkers in oncological clinical trials: Current techniques and standardization challenges2095-882X10.1016/j.cdtm.2017.02.002https://doaj.org/article/57b5325a19b3403a9a7dc989c0342e582017-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X16301347https://doaj.org/toc/2095-882XRadiological imaging plays an important role in oncological trials to provide imaging biomarkers for disease staging, stratifying patients, defining dose setting, and evaluating the safety and efficacy of new candidate drugs and innovative treatment. This paper reviews the techniques of most commonly used quantitative magnetic resonance imaging (qMRI) biomarkers (dynamic contrast enhanced, dynamic susceptibility contrast, and diffusion weighted imaging) and their applications in oncological trials. Challenges of incorporating qMRI biomarkers in oncological trials are discussed including understanding biological mechanisms revealed by MRI biomarkers, consideration of rigorous trial design and standardized implementation of qMRI protocols. Keywords: Quantitative magnetic resonance imaging, Biomarkers, Oncological clinical trialsJie DengYi WangKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 3, Iss 1, Pp 8-20 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Jie Deng Yi Wang Quantitative magnetic resonance imaging biomarkers in oncological clinical trials: Current techniques and standardization challenges
description	Radiological imaging plays an important role in oncological trials to provide imaging biomarkers for disease staging, stratifying patients, defining dose setting, and evaluating the safety and efficacy of new candidate drugs and innovative treatment. This paper reviews the techniques of most commonly used quantitative magnetic resonance imaging (qMRI) biomarkers (dynamic contrast enhanced, dynamic susceptibility contrast, and diffusion weighted imaging) and their applications in oncological trials. Challenges of incorporating qMRI biomarkers in oncological trials are discussed including understanding biological mechanisms revealed by MRI biomarkers, consideration of rigorous trial design and standardized implementation of qMRI protocols. Keywords: Quantitative magnetic resonance imaging, Biomarkers, Oncological clinical trials
format	article
author	Jie Deng Yi Wang
author_facet	Jie Deng Yi Wang
author_sort	Jie Deng
title	Quantitative magnetic resonance imaging biomarkers in oncological clinical trials: Current techniques and standardization challenges
title_short	Quantitative magnetic resonance imaging biomarkers in oncological clinical trials: Current techniques and standardization challenges
title_full	Quantitative magnetic resonance imaging biomarkers in oncological clinical trials: Current techniques and standardization challenges
title_fullStr	Quantitative magnetic resonance imaging biomarkers in oncological clinical trials: Current techniques and standardization challenges
title_full_unstemmed	Quantitative magnetic resonance imaging biomarkers in oncological clinical trials: Current techniques and standardization challenges
title_sort	quantitative magnetic resonance imaging biomarkers in oncological clinical trials: current techniques and standardization challenges
publisher	KeAi Communications Co., Ltd.
publishDate	2017
url	https://doaj.org/article/57b5325a19b3403a9a7dc989c0342e58
work_keys_str_mv	AT jiedeng quantitativemagneticresonanceimagingbiomarkersinoncologicalclinicaltrialscurrenttechniquesandstandardizationchallenges AT yiwang quantitativemagneticresonanceimagingbiomarkersinoncologicalclinicaltrialscurrenttechniquesandstandardizationchallenges
_version_	1718392615821377536

Quantitative magnetic resonance imaging biomarkers in oncological clinical trials: Current techniques and standardization challenges

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