Loss of Ambra1 promotes melanoma growth and invasion

Loss of Ambra1 promotes melanoma growth and invasion

The absence of scaffold protein Ambra1 leads to hyperproliferation and growth in mouse models. Here the authors show that Ambra1 deficiency accelerates melanoma growth and increases metastasis in mouse models of melanoma through FAK1 hyperactivation.

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Detalles Bibliográficos
Autores principales: Luca Di Leo, Valérie Bodemeyer, Francesca M. Bosisio, Giuseppina Claps, Marco Carretta, Salvatore Rizza, Fiorella Faienza, Alex Frias, Shawez Khan, Matteo Bordi, Maria P. Pacheco, Julie Di Martino, Jose J. Bravo-Cordero, Colin J. Daniel, Rosalie C. Sears, Marco Donia, Daniel H. Madsen, Per Guldberg, Giuseppe Filomeni, Thomas Sauter, Caroline Robert, Daniela De Zio, Francesco Cecconi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
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Acceso en línea:https://doaj.org/article/57c07f6892f24e98b8abf330dfb96699
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Descripción
Sumario:The absence of scaffold protein Ambra1 leads to hyperproliferation and growth in mouse models. Here the authors show that Ambra1 deficiency accelerates melanoma growth and increases metastasis in mouse models of melanoma through FAK1 hyperactivation.

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