Loss of Ambra1 promotes melanoma growth and invasion

The absence of scaffold protein Ambra1 leads to hyperproliferation and growth in mouse models. Here the authors show that Ambra1 deficiency accelerates melanoma growth and increases metastasis in mouse models of melanoma through FAK1 hyperactivation.

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Autores principales:	Luca Di Leo, Valérie Bodemeyer, Francesca M. Bosisio, Giuseppina Claps, Marco Carretta, Salvatore Rizza, Fiorella Faienza, Alex Frias, Shawez Khan, Matteo Bordi, Maria P. Pacheco, Julie Di Martino, Jose J. Bravo-Cordero, Colin J. Daniel, Rosalie C. Sears, Marco Donia, Daniel H. Madsen, Per Guldberg, Giuseppe Filomeni, Thomas Sauter, Caroline Robert, Daniela De Zio, Francesco Cecconi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/57c07f6892f24e98b8abf330dfb96699
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spelling	oai:doaj.org-article:57c07f6892f24e98b8abf330dfb966992021-12-02T16:51:30ZLoss of Ambra1 promotes melanoma growth and invasion10.1038/s41467-021-22772-22041-1723https://doaj.org/article/57c07f6892f24e98b8abf330dfb966992021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22772-2https://doaj.org/toc/2041-1723The absence of scaffold protein Ambra1 leads to hyperproliferation and growth in mouse models. Here the authors show that Ambra1 deficiency accelerates melanoma growth and increases metastasis in mouse models of melanoma through FAK1 hyperactivation.Luca Di LeoValérie BodemeyerFrancesca M. BosisioGiuseppina ClapsMarco CarrettaSalvatore RizzaFiorella FaienzaAlex FriasShawez KhanMatteo BordiMaria P. PachecoJulie Di MartinoJose J. Bravo-CorderoColin J. DanielRosalie C. SearsMarco DoniaDaniel H. MadsenPer GuldbergGiuseppe FilomeniThomas SauterCaroline RobertDaniela De ZioFrancesco CecconiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luca Di Leo Valérie Bodemeyer Francesca M. Bosisio Giuseppina Claps Marco Carretta Salvatore Rizza Fiorella Faienza Alex Frias Shawez Khan Matteo Bordi Maria P. Pacheco Julie Di Martino Jose J. Bravo-Cordero Colin J. Daniel Rosalie C. Sears Marco Donia Daniel H. Madsen Per Guldberg Giuseppe Filomeni Thomas Sauter Caroline Robert Daniela De Zio Francesco Cecconi Loss of Ambra1 promotes melanoma growth and invasion
description	The absence of scaffold protein Ambra1 leads to hyperproliferation and growth in mouse models. Here the authors show that Ambra1 deficiency accelerates melanoma growth and increases metastasis in mouse models of melanoma through FAK1 hyperactivation.
format	article
author	Luca Di Leo Valérie Bodemeyer Francesca M. Bosisio Giuseppina Claps Marco Carretta Salvatore Rizza Fiorella Faienza Alex Frias Shawez Khan Matteo Bordi Maria P. Pacheco Julie Di Martino Jose J. Bravo-Cordero Colin J. Daniel Rosalie C. Sears Marco Donia Daniel H. Madsen Per Guldberg Giuseppe Filomeni Thomas Sauter Caroline Robert Daniela De Zio Francesco Cecconi
author_facet	Luca Di Leo Valérie Bodemeyer Francesca M. Bosisio Giuseppina Claps Marco Carretta Salvatore Rizza Fiorella Faienza Alex Frias Shawez Khan Matteo Bordi Maria P. Pacheco Julie Di Martino Jose J. Bravo-Cordero Colin J. Daniel Rosalie C. Sears Marco Donia Daniel H. Madsen Per Guldberg Giuseppe Filomeni Thomas Sauter Caroline Robert Daniela De Zio Francesco Cecconi
author_sort	Luca Di Leo
title	Loss of Ambra1 promotes melanoma growth and invasion
title_short	Loss of Ambra1 promotes melanoma growth and invasion
title_full	Loss of Ambra1 promotes melanoma growth and invasion
title_fullStr	Loss of Ambra1 promotes melanoma growth and invasion
title_full_unstemmed	Loss of Ambra1 promotes melanoma growth and invasion
title_sort	loss of ambra1 promotes melanoma growth and invasion
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/57c07f6892f24e98b8abf330dfb96699
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Loss of Ambra1 promotes melanoma growth and invasion

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