Whole-Genome Selective Scans Detect Genes Associated With Important Phenotypic Traits in Sheep (Ovis aries)

Sheep (Ovis aries) is one of the important livestock with diverse phenotypic traits. However, little is known about the molecular mechanism of diverse phenotypic traits in domestic sheep. Using the genome-wide high-density SNP data (600K) in 253 samples from 13 populations, we conducted the tests of...

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Autores principales:	Song-Song Xu, Lei Gao, Min Shen, Fenghua Lyu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	artificial selection genome-wide SNPs sheep phenotypic traits genetic improvement Genetics QH426-470
Acceso en línea:	https://doaj.org/article/57c0e54cf1b648dfab8009fe643dbaa3
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spelling	oai:doaj.org-article:57c0e54cf1b648dfab8009fe643dbaa32021-11-18T09:48:21ZWhole-Genome Selective Scans Detect Genes Associated With Important Phenotypic Traits in Sheep (Ovis aries)1664-802110.3389/fgene.2021.738879https://doaj.org/article/57c0e54cf1b648dfab8009fe643dbaa32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.738879/fullhttps://doaj.org/toc/1664-8021Sheep (Ovis aries) is one of the important livestock with diverse phenotypic traits. However, little is known about the molecular mechanism of diverse phenotypic traits in domestic sheep. Using the genome-wide high-density SNP data (600K) in 253 samples from 13 populations, we conducted the tests of selective sweeps (i.e., pairwise FST and XP-CLR) associated with several important phenotypic traits (e.g., tail types, horn morphology, prolificacy, coat pigmentation, ear size, milk production, meat production, body size and wool fineness). We identified strong selective signatures in previously reported (e.g., T, RXFP2, BMPR1B, TYRP1, MSRB3, TF, CEBPA, GPR21 and HOXC8) and novel genes associated with the traits, such as CERS6, BTG1, RYR3, SLC6A4, NNAT and OGT for fat deposition in the tails, FOXO4 for fertility, PTCH1 and EMX2 for ear size, and RMI1 and SCD5 for body size. Further gene annotation analysis showed that these genes were identified to be the most probable genes accounting for the diverse phenotypic traits. Our results provide novel insights into the genetic mechanisms underlying the traits and also new genetic markers for genetic improvement in sheep and other livestock.Song-Song XuSong-Song XuLei GaoMin ShenFenghua LyuFrontiers Media S.A.articleartificial selectiongenome-wide SNPssheepphenotypic traitsgenetic improvementGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	artificial selection genome-wide SNPs sheep phenotypic traits genetic improvement Genetics QH426-470
spellingShingle	artificial selection genome-wide SNPs sheep phenotypic traits genetic improvement Genetics QH426-470 Song-Song Xu Song-Song Xu Lei Gao Min Shen Fenghua Lyu Whole-Genome Selective Scans Detect Genes Associated With Important Phenotypic Traits in Sheep (Ovis aries)
description	Sheep (Ovis aries) is one of the important livestock with diverse phenotypic traits. However, little is known about the molecular mechanism of diverse phenotypic traits in domestic sheep. Using the genome-wide high-density SNP data (600K) in 253 samples from 13 populations, we conducted the tests of selective sweeps (i.e., pairwise FST and XP-CLR) associated with several important phenotypic traits (e.g., tail types, horn morphology, prolificacy, coat pigmentation, ear size, milk production, meat production, body size and wool fineness). We identified strong selective signatures in previously reported (e.g., T, RXFP2, BMPR1B, TYRP1, MSRB3, TF, CEBPA, GPR21 and HOXC8) and novel genes associated with the traits, such as CERS6, BTG1, RYR3, SLC6A4, NNAT and OGT for fat deposition in the tails, FOXO4 for fertility, PTCH1 and EMX2 for ear size, and RMI1 and SCD5 for body size. Further gene annotation analysis showed that these genes were identified to be the most probable genes accounting for the diverse phenotypic traits. Our results provide novel insights into the genetic mechanisms underlying the traits and also new genetic markers for genetic improvement in sheep and other livestock.
format	article
author	Song-Song Xu Song-Song Xu Lei Gao Min Shen Fenghua Lyu
author_facet	Song-Song Xu Song-Song Xu Lei Gao Min Shen Fenghua Lyu
author_sort	Song-Song Xu
title	Whole-Genome Selective Scans Detect Genes Associated With Important Phenotypic Traits in Sheep (Ovis aries)
title_short	Whole-Genome Selective Scans Detect Genes Associated With Important Phenotypic Traits in Sheep (Ovis aries)
title_full	Whole-Genome Selective Scans Detect Genes Associated With Important Phenotypic Traits in Sheep (Ovis aries)
title_fullStr	Whole-Genome Selective Scans Detect Genes Associated With Important Phenotypic Traits in Sheep (Ovis aries)
title_full_unstemmed	Whole-Genome Selective Scans Detect Genes Associated With Important Phenotypic Traits in Sheep (Ovis aries)
title_sort	whole-genome selective scans detect genes associated with important phenotypic traits in sheep (ovis aries)
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/57c0e54cf1b648dfab8009fe643dbaa3
work_keys_str_mv	AT songsongxu wholegenomeselectivescansdetectgenesassociatedwithimportantphenotypictraitsinsheepovisaries AT songsongxu wholegenomeselectivescansdetectgenesassociatedwithimportantphenotypictraitsinsheepovisaries AT leigao wholegenomeselectivescansdetectgenesassociatedwithimportantphenotypictraitsinsheepovisaries AT minshen wholegenomeselectivescansdetectgenesassociatedwithimportantphenotypictraitsinsheepovisaries AT fenghualyu wholegenomeselectivescansdetectgenesassociatedwithimportantphenotypictraitsinsheepovisaries
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Whole-Genome Selective Scans Detect Genes Associated With Important Phenotypic Traits in Sheep (Ovis aries)

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