Causes and consequences of obesity: epigenetics or hypokinesis?

Michael R Graham,1 Julien S Baker,2 Bruce Davies3 1Llantarnam Research Academy, Cwmbran, Torfaen, UK; 2Exercise Science Research Laboratory, Institute of Clinical Exercise and Health Science, School of Science, University of the West of Scotland, Hamilton, UK; 3Science Department, University of Sout...

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Autores principales:	Graham MR, Baker JS, Davies B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/57c0ec210e084667b4df7f4b5b8b0ffa
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spelling	oai:doaj.org-article:57c0ec210e084667b4df7f4b5b8b0ffa2021-12-02T03:07:06ZCauses and consequences of obesity: epigenetics or hypokinesis?1178-7007https://doaj.org/article/57c0ec210e084667b4df7f4b5b8b0ffa2015-09-01T00:00:00Zhttps://www.dovepress.com/causes-and-consequences-of-obesity-epigenetics-or-hypokinesis-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Michael R Graham,1 Julien S Baker,2 Bruce Davies3 1Llantarnam Research Academy, Cwmbran, Torfaen, UK; 2Exercise Science Research Laboratory, Institute of Clinical Exercise and Health Science, School of Science, University of the West of Scotland, Hamilton, UK; 3Science Department, University of South Wales, Newport, UKEpigenetics can be defined as the study of heritable changes that affect gene function without modification of the deoxyribonucleic acid (DNA) sequence.1 The transfer of epigenetic marks through generations is not well understood, and their transmission is in dispute.2 Epigenetic marks are tissue-specific and include DNA methylation and histone modifications that mediate biological processes, such as imprinting (Figure 1). Many imprinted genes are regulators of gene expression controlling growth. Imprinting disorders often feature obesity as one of their characteristics.3Graham MRBaker JSDavies BDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2015, Iss default, Pp 455-460 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Graham MR Baker JS Davies B Causes and consequences of obesity: epigenetics or hypokinesis?
description	Michael R Graham,1 Julien S Baker,2 Bruce Davies3 1Llantarnam Research Academy, Cwmbran, Torfaen, UK; 2Exercise Science Research Laboratory, Institute of Clinical Exercise and Health Science, School of Science, University of the West of Scotland, Hamilton, UK; 3Science Department, University of South Wales, Newport, UKEpigenetics can be defined as the study of heritable changes that affect gene function without modification of the deoxyribonucleic acid (DNA) sequence.1 The transfer of epigenetic marks through generations is not well understood, and their transmission is in dispute.2 Epigenetic marks are tissue-specific and include DNA methylation and histone modifications that mediate biological processes, such as imprinting (Figure 1). Many imprinted genes are regulators of gene expression controlling growth. Imprinting disorders often feature obesity as one of their characteristics.3
format	article
author	Graham MR Baker JS Davies B
author_facet	Graham MR Baker JS Davies B
author_sort	Graham MR
title	Causes and consequences of obesity: epigenetics or hypokinesis?
title_short	Causes and consequences of obesity: epigenetics or hypokinesis?
title_full	Causes and consequences of obesity: epigenetics or hypokinesis?
title_fullStr	Causes and consequences of obesity: epigenetics or hypokinesis?
title_full_unstemmed	Causes and consequences of obesity: epigenetics or hypokinesis?
title_sort	causes and consequences of obesity: epigenetics or hypokinesis?
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/57c0ec210e084667b4df7f4b5b8b0ffa
work_keys_str_mv	AT grahammr causesandconsequencesofobesityepigeneticsorhypokinesis AT bakerjs causesandconsequencesofobesityepigeneticsorhypokinesis AT daviesb causesandconsequencesofobesityepigeneticsorhypokinesis
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Causes and consequences of obesity: epigenetics or hypokinesis?

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