Cell metabolism regulates integrin mechanosensing via an SLC3A2-dependent sphingolipid biosynthesis pathway

Mechanical and metabolic cues contribute to regulate cell and tissue homeostasis but how they are integrated is not known. Here the authors show that the amino acid transporter and integrin coreceptor CD98hc regulates mechanical signaling downstream of integrins indirectly through regulating sphingo...

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Autores principales:	Etienne Boulter, Soline Estrach, Floriane S. Tissot, Marco L. Hennrich, Lionel Tosello, Laurence Cailleteau, Laura R. de la Ballina, Sabrina Pisano, Anne-Claude Gavin, Chloé C. Féral
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/57cabe34ca7f4253b5ef301fc4179fe9
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spelling	oai:doaj.org-article:57cabe34ca7f4253b5ef301fc4179fe92021-12-02T14:38:50ZCell metabolism regulates integrin mechanosensing via an SLC3A2-dependent sphingolipid biosynthesis pathway10.1038/s41467-018-07268-w2041-1723https://doaj.org/article/57cabe34ca7f4253b5ef301fc4179fe92018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07268-whttps://doaj.org/toc/2041-1723Mechanical and metabolic cues contribute to regulate cell and tissue homeostasis but how they are integrated is not known. Here the authors show that the amino acid transporter and integrin coreceptor CD98hc regulates mechanical signaling downstream of integrins indirectly through regulating sphingolipid availability.Etienne BoulterSoline EstrachFloriane S. TissotMarco L. HennrichLionel ToselloLaurence CailleteauLaura R. de la BallinaSabrina PisanoAnne-Claude GavinChloé C. FéralNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Etienne Boulter Soline Estrach Floriane S. Tissot Marco L. Hennrich Lionel Tosello Laurence Cailleteau Laura R. de la Ballina Sabrina Pisano Anne-Claude Gavin Chloé C. Féral Cell metabolism regulates integrin mechanosensing via an SLC3A2-dependent sphingolipid biosynthesis pathway
description	Mechanical and metabolic cues contribute to regulate cell and tissue homeostasis but how they are integrated is not known. Here the authors show that the amino acid transporter and integrin coreceptor CD98hc regulates mechanical signaling downstream of integrins indirectly through regulating sphingolipid availability.
format	article
author	Etienne Boulter Soline Estrach Floriane S. Tissot Marco L. Hennrich Lionel Tosello Laurence Cailleteau Laura R. de la Ballina Sabrina Pisano Anne-Claude Gavin Chloé C. Féral
author_facet	Etienne Boulter Soline Estrach Floriane S. Tissot Marco L. Hennrich Lionel Tosello Laurence Cailleteau Laura R. de la Ballina Sabrina Pisano Anne-Claude Gavin Chloé C. Féral
author_sort	Etienne Boulter
title	Cell metabolism regulates integrin mechanosensing via an SLC3A2-dependent sphingolipid biosynthesis pathway
title_short	Cell metabolism regulates integrin mechanosensing via an SLC3A2-dependent sphingolipid biosynthesis pathway
title_full	Cell metabolism regulates integrin mechanosensing via an SLC3A2-dependent sphingolipid biosynthesis pathway
title_fullStr	Cell metabolism regulates integrin mechanosensing via an SLC3A2-dependent sphingolipid biosynthesis pathway
title_full_unstemmed	Cell metabolism regulates integrin mechanosensing via an SLC3A2-dependent sphingolipid biosynthesis pathway
title_sort	cell metabolism regulates integrin mechanosensing via an slc3a2-dependent sphingolipid biosynthesis pathway
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/57cabe34ca7f4253b5ef301fc4179fe9
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Cell metabolism regulates integrin mechanosensing via an SLC3A2-dependent sphingolipid biosynthesis pathway

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