PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase

mTORC1 is an important regulator of muscle mass. Here, the authors show that the PHD1 controls muscle mass in a hydroxylation-independent manner. PHD1 prevents the degradation of leucine sensor LRS during oxygen and amino acid depletion to ensure effective mTORC1 activation in response to leucine.

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Detalles Bibliográficos
Autores principales:	Gommaar D’Hulst, Inés Soro-Arnaiz, Evi Masschelein, Koen Veys, Gillian Fitzgerald, Benoit Smeuninx, Sunghoon Kim, Louise Deldicque, Bert Blaauw, Peter Carmeliet, Leigh Breen, Peppi Koivunen, Shi-Min Zhao, Katrien De Bock
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/57ce964136154da49cd0e8f1b72242c1
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spelling	oai:doaj.org-article:57ce964136154da49cd0e8f1b72242c12021-12-02T16:49:46ZPHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase10.1038/s41467-019-13889-62041-1723https://doaj.org/article/57ce964136154da49cd0e8f1b72242c12020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13889-6https://doaj.org/toc/2041-1723mTORC1 is an important regulator of muscle mass. Here, the authors show that the PHD1 controls muscle mass in a hydroxylation-independent manner. PHD1 prevents the degradation of leucine sensor LRS during oxygen and amino acid depletion to ensure effective mTORC1 activation in response to leucine.Gommaar D’HulstInés Soro-ArnaizEvi MasscheleinKoen VeysGillian FitzgeraldBenoit SmeuninxSunghoon KimLouise DeldicqueBert BlaauwPeter CarmelietLeigh BreenPeppi KoivunenShi-Min ZhaoKatrien De BockNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gommaar D’Hulst Inés Soro-Arnaiz Evi Masschelein Koen Veys Gillian Fitzgerald Benoit Smeuninx Sunghoon Kim Louise Deldicque Bert Blaauw Peter Carmeliet Leigh Breen Peppi Koivunen Shi-Min Zhao Katrien De Bock PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase
description	mTORC1 is an important regulator of muscle mass. Here, the authors show that the PHD1 controls muscle mass in a hydroxylation-independent manner. PHD1 prevents the degradation of leucine sensor LRS during oxygen and amino acid depletion to ensure effective mTORC1 activation in response to leucine.
format	article
author	Gommaar D’Hulst Inés Soro-Arnaiz Evi Masschelein Koen Veys Gillian Fitzgerald Benoit Smeuninx Sunghoon Kim Louise Deldicque Bert Blaauw Peter Carmeliet Leigh Breen Peppi Koivunen Shi-Min Zhao Katrien De Bock
author_facet	Gommaar D’Hulst Inés Soro-Arnaiz Evi Masschelein Koen Veys Gillian Fitzgerald Benoit Smeuninx Sunghoon Kim Louise Deldicque Bert Blaauw Peter Carmeliet Leigh Breen Peppi Koivunen Shi-Min Zhao Katrien De Bock
author_sort	Gommaar D’Hulst
title	PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase
title_short	PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase
title_full	PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase
title_fullStr	PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase
title_full_unstemmed	PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase
title_sort	phd1 controls muscle mtorc1 in a hydroxylation-independent manner by stabilizing leucyl trna synthetase
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/57ce964136154da49cd0e8f1b72242c1
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PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase

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