Parallel evolution of the genetic code in arthropod mitochondrial genomes.

The genetic code provides the translation table necessary to transform the information contained in DNA into the language of proteins. In this table, a correspondence between each codon and each amino acid is established: tRNA is the main adaptor that links the two. Although the genetic code is near...

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Autores principales:	Federico Abascal, David Posada, Robin D Knight, Rafael Zardoya
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2006
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/57d3a98d190f4b4ebb5c7c50c93a731b
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spelling	oai:doaj.org-article:57d3a98d190f4b4ebb5c7c50c93a731b2021-11-25T05:33:11ZParallel evolution of the genetic code in arthropod mitochondrial genomes.1544-91731545-788510.1371/journal.pbio.0040127https://doaj.org/article/57d3a98d190f4b4ebb5c7c50c93a731b2006-05-01T00:00:00Zhttps://doi.org/10.1371/journal.pbio.0040127https://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885The genetic code provides the translation table necessary to transform the information contained in DNA into the language of proteins. In this table, a correspondence between each codon and each amino acid is established: tRNA is the main adaptor that links the two. Although the genetic code is nearly universal, several variants of this code have been described in a wide range of nuclear and organellar systems, especially in metazoan mitochondria. These variants are generally found by searching for conserved positions that consistently code for a specific alternative amino acid in a new species. We have devised an accurate computational method to automate these comparisons, and have tested it with 626 metazoan mitochondrial genomes. Our results indicate that several arthropods have a new genetic code and translate the codon AGG as lysine instead of serine (as in the invertebrate mitochondrial genetic code) or arginine (as in the standard genetic code). We have investigated the evolution of the genetic code in the arthropods and found several events of parallel evolution in which the AGG codon was reassigned between serine and lysine. Our analyses also revealed correlated evolution between the arthropod genetic codes and the tRNA-Lys/-Ser, which show specific point mutations at the anticodons. These rather simple mutations, together with a low usage of the AGG codon, might explain the recurrence of the AGG reassignments.Federico AbascalDavid PosadaRobin D KnightRafael ZardoyaPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 4, Iss 5, p e127 (2006)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Federico Abascal David Posada Robin D Knight Rafael Zardoya Parallel evolution of the genetic code in arthropod mitochondrial genomes.
description	The genetic code provides the translation table necessary to transform the information contained in DNA into the language of proteins. In this table, a correspondence between each codon and each amino acid is established: tRNA is the main adaptor that links the two. Although the genetic code is nearly universal, several variants of this code have been described in a wide range of nuclear and organellar systems, especially in metazoan mitochondria. These variants are generally found by searching for conserved positions that consistently code for a specific alternative amino acid in a new species. We have devised an accurate computational method to automate these comparisons, and have tested it with 626 metazoan mitochondrial genomes. Our results indicate that several arthropods have a new genetic code and translate the codon AGG as lysine instead of serine (as in the invertebrate mitochondrial genetic code) or arginine (as in the standard genetic code). We have investigated the evolution of the genetic code in the arthropods and found several events of parallel evolution in which the AGG codon was reassigned between serine and lysine. Our analyses also revealed correlated evolution between the arthropod genetic codes and the tRNA-Lys/-Ser, which show specific point mutations at the anticodons. These rather simple mutations, together with a low usage of the AGG codon, might explain the recurrence of the AGG reassignments.
format	article
author	Federico Abascal David Posada Robin D Knight Rafael Zardoya
author_facet	Federico Abascal David Posada Robin D Knight Rafael Zardoya
author_sort	Federico Abascal
title	Parallel evolution of the genetic code in arthropod mitochondrial genomes.
title_short	Parallel evolution of the genetic code in arthropod mitochondrial genomes.
title_full	Parallel evolution of the genetic code in arthropod mitochondrial genomes.
title_fullStr	Parallel evolution of the genetic code in arthropod mitochondrial genomes.
title_full_unstemmed	Parallel evolution of the genetic code in arthropod mitochondrial genomes.
title_sort	parallel evolution of the genetic code in arthropod mitochondrial genomes.
publisher	Public Library of Science (PLoS)
publishDate	2006
url	https://doaj.org/article/57d3a98d190f4b4ebb5c7c50c93a731b
work_keys_str_mv	AT federicoabascal parallelevolutionofthegeneticcodeinarthropodmitochondrialgenomes AT davidposada parallelevolutionofthegeneticcodeinarthropodmitochondrialgenomes AT robindknight parallelevolutionofthegeneticcodeinarthropodmitochondrialgenomes AT rafaelzardoya parallelevolutionofthegeneticcodeinarthropodmitochondrialgenomes
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Parallel evolution of the genetic code in arthropod mitochondrial genomes.

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