HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells

The identification of mRNA targets for RNA binding proteins (RBP) in stem cells is difficult due to the limited number of available cells. Here, as a proof-of-principle, the authors adapt the HyperTRIBE method to find that an RBP, MSI2, has increased RNA binding in leukemic compared with normal stem...

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Autores principales:	Diu T. T. Nguyen, Yuheng Lu, Karen L. Chu, Xuejing Yang, Sun-Mi Park, Zi-Ning Choo, Christopher R. Chin, Camila Prieto, Alexandra Schurer, Ersilia Barin, Angela M. Savino, Saroj Gourkanti, Payal Patel, Ly P. Vu, Christina S. Leslie, Michael G. Kharas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/57d9dd401d274463904c8c3f4b95b1ec
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spelling	oai:doaj.org-article:57d9dd401d274463904c8c3f4b95b1ec2021-12-02T16:50:02ZHyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells10.1038/s41467-020-15814-82041-1723https://doaj.org/article/57d9dd401d274463904c8c3f4b95b1ec2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15814-8https://doaj.org/toc/2041-1723The identification of mRNA targets for RNA binding proteins (RBP) in stem cells is difficult due to the limited number of available cells. Here, as a proof-of-principle, the authors adapt the HyperTRIBE method to find that an RBP, MSI2, has increased RNA binding in leukemic compared with normal stem cells for selective regulation of oncogenic genes.Diu T. T. NguyenYuheng LuKaren L. ChuXuejing YangSun-Mi ParkZi-Ning ChooChristopher R. ChinCamila PrietoAlexandra SchurerErsilia BarinAngela M. SavinoSaroj GourkantiPayal PatelLy P. VuChristina S. LeslieMichael G. KharasNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Diu T. T. Nguyen Yuheng Lu Karen L. Chu Xuejing Yang Sun-Mi Park Zi-Ning Choo Christopher R. Chin Camila Prieto Alexandra Schurer Ersilia Barin Angela M. Savino Saroj Gourkanti Payal Patel Ly P. Vu Christina S. Leslie Michael G. Kharas HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells
description	The identification of mRNA targets for RNA binding proteins (RBP) in stem cells is difficult due to the limited number of available cells. Here, as a proof-of-principle, the authors adapt the HyperTRIBE method to find that an RBP, MSI2, has increased RNA binding in leukemic compared with normal stem cells for selective regulation of oncogenic genes.
format	article
author	Diu T. T. Nguyen Yuheng Lu Karen L. Chu Xuejing Yang Sun-Mi Park Zi-Ning Choo Christopher R. Chin Camila Prieto Alexandra Schurer Ersilia Barin Angela M. Savino Saroj Gourkanti Payal Patel Ly P. Vu Christina S. Leslie Michael G. Kharas
author_facet	Diu T. T. Nguyen Yuheng Lu Karen L. Chu Xuejing Yang Sun-Mi Park Zi-Ning Choo Christopher R. Chin Camila Prieto Alexandra Schurer Ersilia Barin Angela M. Savino Saroj Gourkanti Payal Patel Ly P. Vu Christina S. Leslie Michael G. Kharas
author_sort	Diu T. T. Nguyen
title	HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells
title_short	HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells
title_full	HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells
title_fullStr	HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells
title_full_unstemmed	HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells
title_sort	hypertribe uncovers increased musashi-2 rna binding activity and differential regulation in leukemic stem cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/57d9dd401d274463904c8c3f4b95b1ec
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HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells

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