Differential neural activation patterns in patients with Parkinson's disease and freezing of gait in response to concurrent cognitive and motor load.

Freezing of gait is a devastating symptom of Parkinson's disease (PD) that is exacerbated by the processing of cognitive information whilst walking. To date, no studies have explored the neural correlates associated with increases in cognitive load whilst performing a motor task in patients wit...

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Autores principales:	James M Shine, Elie Matar, Philip B Ward, Samuel J Bolitho, Mark Pearson, Sharon L Naismith, Simon J G Lewis
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/57e042d4a1dd499b957c0522ce6ee865
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spelling	oai:doaj.org-article:57e042d4a1dd499b957c0522ce6ee8652021-11-18T07:59:37ZDifferential neural activation patterns in patients with Parkinson's disease and freezing of gait in response to concurrent cognitive and motor load.1932-620310.1371/journal.pone.0052602https://doaj.org/article/57e042d4a1dd499b957c0522ce6ee8652013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23382821/?tool=EBIhttps://doaj.org/toc/1932-6203Freezing of gait is a devastating symptom of Parkinson's disease (PD) that is exacerbated by the processing of cognitive information whilst walking. To date, no studies have explored the neural correlates associated with increases in cognitive load whilst performing a motor task in patients with freezing. In this experiment, 14 PD patients with and 15 PD patients without freezing of gait underwent 3T fMRI while performing a virtual reality gait task. Directions to walk and stop were presented on the viewing screen as either direct cues or as more cognitively indirect pre-learned cues. Both groups showed a consistent pattern of BOLD response within the Cognitive Control Network during performance of the paradigm. However, a between group comparison revealed that those PD patients with freezing of gait were less able to recruit the bilateral anterior insula, ventral striatum and the pre-supplementary motor area, as well as the left subthalamic nucleus when responding to indirect cognitive cues whilst maintaining a motor output. These results suggest that PD patients with freezing of gait are unable to properly recruit specific cortical and subcortical regions within the Cognitive Control Network during the performance of simultaneous motor and cognitive functions.James M ShineElie MatarPhilip B WardSamuel J BolithoMark PearsonSharon L NaismithSimon J G LewisPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e52602 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q James M Shine Elie Matar Philip B Ward Samuel J Bolitho Mark Pearson Sharon L Naismith Simon J G Lewis Differential neural activation patterns in patients with Parkinson's disease and freezing of gait in response to concurrent cognitive and motor load.
description	Freezing of gait is a devastating symptom of Parkinson's disease (PD) that is exacerbated by the processing of cognitive information whilst walking. To date, no studies have explored the neural correlates associated with increases in cognitive load whilst performing a motor task in patients with freezing. In this experiment, 14 PD patients with and 15 PD patients without freezing of gait underwent 3T fMRI while performing a virtual reality gait task. Directions to walk and stop were presented on the viewing screen as either direct cues or as more cognitively indirect pre-learned cues. Both groups showed a consistent pattern of BOLD response within the Cognitive Control Network during performance of the paradigm. However, a between group comparison revealed that those PD patients with freezing of gait were less able to recruit the bilateral anterior insula, ventral striatum and the pre-supplementary motor area, as well as the left subthalamic nucleus when responding to indirect cognitive cues whilst maintaining a motor output. These results suggest that PD patients with freezing of gait are unable to properly recruit specific cortical and subcortical regions within the Cognitive Control Network during the performance of simultaneous motor and cognitive functions.
format	article
author	James M Shine Elie Matar Philip B Ward Samuel J Bolitho Mark Pearson Sharon L Naismith Simon J G Lewis
author_facet	James M Shine Elie Matar Philip B Ward Samuel J Bolitho Mark Pearson Sharon L Naismith Simon J G Lewis
author_sort	James M Shine
title	Differential neural activation patterns in patients with Parkinson's disease and freezing of gait in response to concurrent cognitive and motor load.
title_short	Differential neural activation patterns in patients with Parkinson's disease and freezing of gait in response to concurrent cognitive and motor load.
title_full	Differential neural activation patterns in patients with Parkinson's disease and freezing of gait in response to concurrent cognitive and motor load.
title_fullStr	Differential neural activation patterns in patients with Parkinson's disease and freezing of gait in response to concurrent cognitive and motor load.
title_full_unstemmed	Differential neural activation patterns in patients with Parkinson's disease and freezing of gait in response to concurrent cognitive and motor load.
title_sort	differential neural activation patterns in patients with parkinson's disease and freezing of gait in response to concurrent cognitive and motor load.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/57e042d4a1dd499b957c0522ce6ee865
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Differential neural activation patterns in patients with Parkinson's disease and freezing of gait in response to concurrent cognitive and motor load.

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