Konzo: from poverty, cassava, and cyanogen intake to toxico-nutritional neurological disease.

Konzo is a distinct neurological entity with selective upper motor neuron damage, characterized by an abrupt onset of an irreversible, non-progressive, and symmetrical spastic para/tetraparesis. Despite its severity, konzo remains a neglected disease. The disease is associated with high dietary cyan...

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Autores principales:	Hipólito Nzwalo, Julie Cliff
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/57e12ea6111146d29aae5bd0ddaaa1f3
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spelling	oai:doaj.org-article:57e12ea6111146d29aae5bd0ddaaa1f32021-11-18T09:13:14ZKonzo: from poverty, cassava, and cyanogen intake to toxico-nutritional neurological disease.1935-27271935-273510.1371/journal.pntd.0001051https://doaj.org/article/57e12ea6111146d29aae5bd0ddaaa1f32011-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21738800/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735Konzo is a distinct neurological entity with selective upper motor neuron damage, characterized by an abrupt onset of an irreversible, non-progressive, and symmetrical spastic para/tetraparesis. Despite its severity, konzo remains a neglected disease. The disease is associated with high dietary cyanogen consumption from insufficiently processed roots of bitter cassava combined with a protein-deficient diet. Epidemics occur when these conditions coincide at times of severe food shortage. Up to 1993, outbreaks in poor rural areas in Africa contributed to more than 3,700 cases of konzo. The number of affected people is underestimated. From unofficial reports, the number of cases was estimated to be at least 100,000 in 2000, in contrast to the 6,788 cases reported up to 2009 from published papers.Hipólito NzwaloJulie CliffPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 5, Iss 6, p e1051 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Hipólito Nzwalo Julie Cliff Konzo: from poverty, cassava, and cyanogen intake to toxico-nutritional neurological disease.
description	Konzo is a distinct neurological entity with selective upper motor neuron damage, characterized by an abrupt onset of an irreversible, non-progressive, and symmetrical spastic para/tetraparesis. Despite its severity, konzo remains a neglected disease. The disease is associated with high dietary cyanogen consumption from insufficiently processed roots of bitter cassava combined with a protein-deficient diet. Epidemics occur when these conditions coincide at times of severe food shortage. Up to 1993, outbreaks in poor rural areas in Africa contributed to more than 3,700 cases of konzo. The number of affected people is underestimated. From unofficial reports, the number of cases was estimated to be at least 100,000 in 2000, in contrast to the 6,788 cases reported up to 2009 from published papers.
format	article
author	Hipólito Nzwalo Julie Cliff
author_facet	Hipólito Nzwalo Julie Cliff
author_sort	Hipólito Nzwalo
title	Konzo: from poverty, cassava, and cyanogen intake to toxico-nutritional neurological disease.
title_short	Konzo: from poverty, cassava, and cyanogen intake to toxico-nutritional neurological disease.
title_full	Konzo: from poverty, cassava, and cyanogen intake to toxico-nutritional neurological disease.
title_fullStr	Konzo: from poverty, cassava, and cyanogen intake to toxico-nutritional neurological disease.
title_full_unstemmed	Konzo: from poverty, cassava, and cyanogen intake to toxico-nutritional neurological disease.
title_sort	konzo: from poverty, cassava, and cyanogen intake to toxico-nutritional neurological disease.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/57e12ea6111146d29aae5bd0ddaaa1f3
work_keys_str_mv	AT hipolitonzwalo konzofrompovertycassavaandcyanogenintaketotoxiconutritionalneurologicaldisease AT juliecliff konzofrompovertycassavaandcyanogenintaketotoxiconutritionalneurologicaldisease
_version_	1718420965316100096

Konzo: from poverty, cassava, and cyanogen intake to toxico-nutritional neurological disease.

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