The Exopolysaccharide Produced by <i>Lactobacillus paracasei</i> IJH-SONE68 Prevents and Ameliorates Inflammatory Responses in DSS–Induced Ulcerative Colitis

Inflammatory bowel disease (IBD) is an autoimmune disease characterized by chronic inflammation of the gastrointestinal tract. IBD includes Crohn’s disease (CD) and ulcerative colitis (UC). CD can occur in any part of the gastrointestinal tract, whereas UC mainly occurs in the colon and rectum. We p...

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Autores principales:	Masafumi Noda, Narandalai Danshiitsoodol, Keishi Kanno, Tomoyuki Uchida, Masanori Sugiyama
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	inflammatory bowel disease (IBD) ulcerative colitis (UC) lactic acid bacteria (LAB) <i>Lactobacillus paracasei</i> exopolysaccharide (EPS) Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/57e3b4930f774e2a9be81957028c243e
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spelling	oai:doaj.org-article:57e3b4930f774e2a9be81957028c243e2021-11-25T18:24:32ZThe Exopolysaccharide Produced by <i>Lactobacillus paracasei</i> IJH-SONE68 Prevents and Ameliorates Inflammatory Responses in DSS–Induced Ulcerative Colitis10.3390/microorganisms91122432076-2607https://doaj.org/article/57e3b4930f774e2a9be81957028c243e2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-2607/9/11/2243https://doaj.org/toc/2076-2607Inflammatory bowel disease (IBD) is an autoimmune disease characterized by chronic inflammation of the gastrointestinal tract. IBD includes Crohn’s disease (CD) and ulcerative colitis (UC). CD can occur in any part of the gastrointestinal tract, whereas UC mainly occurs in the colon and rectum. We previously demonstrated that a novel exopolysaccharide (EPS) produced by a plant-derived bacterium, <i>Lactobacillus paracasei</i> IJH-SONE68, prevents and improves the inflammation in contact dermatitis model mice via oral administration. To evaluate the preventive effect of the EPS against other inflammatory diseases, in the present study, we employed dextran sulfate sodium (DSS)-induced UC model mice. The stool consistency, hematochezia, and colonic atrophy of the mice were improved by the orally administered EPS. We also evaluated the cytokine transcription. Overexpression of the mouse macrophage inflammatory protein 2 mRNA in the colon as a functional homolog of human interleukin-8 was decreased by the orally administered EPS. However, the expression of interleukin-10, which is known as an anti-inflammatory cytokine, was stimulated in the EPS-administrated group. Based on these results, we conclude that the IJH-SONE68-derived EPS is a promising lead material for the development of drugs useful in treating inflammatory diseases such as UC.Masafumi NodaNarandalai DanshiitsoodolKeishi KannoTomoyuki UchidaMasanori SugiyamaMDPI AGarticleinflammatory bowel disease (IBD)ulcerative colitis (UC)lactic acid bacteria (LAB)<i>Lactobacillus paracasei</i>exopolysaccharide (EPS)Biology (General)QH301-705.5ENMicroorganisms, Vol 9, Iss 2243, p 2243 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	inflammatory bowel disease (IBD) ulcerative colitis (UC) lactic acid bacteria (LAB) <i>Lactobacillus paracasei</i> exopolysaccharide (EPS) Biology (General) QH301-705.5
spellingShingle	inflammatory bowel disease (IBD) ulcerative colitis (UC) lactic acid bacteria (LAB) <i>Lactobacillus paracasei</i> exopolysaccharide (EPS) Biology (General) QH301-705.5 Masafumi Noda Narandalai Danshiitsoodol Keishi Kanno Tomoyuki Uchida Masanori Sugiyama The Exopolysaccharide Produced by <i>Lactobacillus paracasei</i> IJH-SONE68 Prevents and Ameliorates Inflammatory Responses in DSS–Induced Ulcerative Colitis
description	Inflammatory bowel disease (IBD) is an autoimmune disease characterized by chronic inflammation of the gastrointestinal tract. IBD includes Crohn’s disease (CD) and ulcerative colitis (UC). CD can occur in any part of the gastrointestinal tract, whereas UC mainly occurs in the colon and rectum. We previously demonstrated that a novel exopolysaccharide (EPS) produced by a plant-derived bacterium, <i>Lactobacillus paracasei</i> IJH-SONE68, prevents and improves the inflammation in contact dermatitis model mice via oral administration. To evaluate the preventive effect of the EPS against other inflammatory diseases, in the present study, we employed dextran sulfate sodium (DSS)-induced UC model mice. The stool consistency, hematochezia, and colonic atrophy of the mice were improved by the orally administered EPS. We also evaluated the cytokine transcription. Overexpression of the mouse macrophage inflammatory protein 2 mRNA in the colon as a functional homolog of human interleukin-8 was decreased by the orally administered EPS. However, the expression of interleukin-10, which is known as an anti-inflammatory cytokine, was stimulated in the EPS-administrated group. Based on these results, we conclude that the IJH-SONE68-derived EPS is a promising lead material for the development of drugs useful in treating inflammatory diseases such as UC.
format	article
author	Masafumi Noda Narandalai Danshiitsoodol Keishi Kanno Tomoyuki Uchida Masanori Sugiyama
author_facet	Masafumi Noda Narandalai Danshiitsoodol Keishi Kanno Tomoyuki Uchida Masanori Sugiyama
author_sort	Masafumi Noda
title	The Exopolysaccharide Produced by <i>Lactobacillus paracasei</i> IJH-SONE68 Prevents and Ameliorates Inflammatory Responses in DSS–Induced Ulcerative Colitis
title_short	The Exopolysaccharide Produced by <i>Lactobacillus paracasei</i> IJH-SONE68 Prevents and Ameliorates Inflammatory Responses in DSS–Induced Ulcerative Colitis
title_full	The Exopolysaccharide Produced by <i>Lactobacillus paracasei</i> IJH-SONE68 Prevents and Ameliorates Inflammatory Responses in DSS–Induced Ulcerative Colitis
title_fullStr	The Exopolysaccharide Produced by <i>Lactobacillus paracasei</i> IJH-SONE68 Prevents and Ameliorates Inflammatory Responses in DSS–Induced Ulcerative Colitis
title_full_unstemmed	The Exopolysaccharide Produced by <i>Lactobacillus paracasei</i> IJH-SONE68 Prevents and Ameliorates Inflammatory Responses in DSS–Induced Ulcerative Colitis
title_sort	exopolysaccharide produced by <i>lactobacillus paracasei</i> ijh-sone68 prevents and ameliorates inflammatory responses in dss–induced ulcerative colitis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/57e3b4930f774e2a9be81957028c243e
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The Exopolysaccharide Produced by <i>Lactobacillus paracasei</i> IJH-SONE68 Prevents and Ameliorates Inflammatory Responses in DSS–Induced Ulcerative Colitis

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