Sumoylation regulates FMRP-mediated dendritic spine elimination and maturation

Fragile X syndrome patients display intellectual disability and autism, caused by mutations in the RNA-binding protein fragile X mental retardation protein (FMRP). Here, the authors show that FMRP sumoylation is required for regulating spine density and maturation.

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Autores principales:	Anouar Khayachi, Carole Gwizdek, Gwénola Poupon, Damien Alcor, Magda Chafai, Frédéric Cassé, Thomas Maurin, Marta Prieto, Alessandra Folci, Fabienne De Graeve, Sara Castagnola, Romain Gautier, Lenka Schorova, Céline Loriol, Marie Pronot, Florence Besse, Frédéric Brau, Emmanuel Deval, Barbara Bardoni, Stéphane Martin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/57e3d66daa9b4a92b4183ee79455e739
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spelling	oai:doaj.org-article:57e3d66daa9b4a92b4183ee79455e7392021-12-02T16:49:50ZSumoylation regulates FMRP-mediated dendritic spine elimination and maturation10.1038/s41467-018-03222-y2041-1723https://doaj.org/article/57e3d66daa9b4a92b4183ee79455e7392018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03222-yhttps://doaj.org/toc/2041-1723Fragile X syndrome patients display intellectual disability and autism, caused by mutations in the RNA-binding protein fragile X mental retardation protein (FMRP). Here, the authors show that FMRP sumoylation is required for regulating spine density and maturation.Anouar KhayachiCarole GwizdekGwénola PouponDamien AlcorMagda ChafaiFrédéric CasséThomas MaurinMarta PrietoAlessandra FolciFabienne De GraeveSara CastagnolaRomain GautierLenka SchorovaCéline LoriolMarie PronotFlorence BesseFrédéric BrauEmmanuel DevalBarbara BardoniStéphane MartinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anouar Khayachi Carole Gwizdek Gwénola Poupon Damien Alcor Magda Chafai Frédéric Cassé Thomas Maurin Marta Prieto Alessandra Folci Fabienne De Graeve Sara Castagnola Romain Gautier Lenka Schorova Céline Loriol Marie Pronot Florence Besse Frédéric Brau Emmanuel Deval Barbara Bardoni Stéphane Martin Sumoylation regulates FMRP-mediated dendritic spine elimination and maturation
description	Fragile X syndrome patients display intellectual disability and autism, caused by mutations in the RNA-binding protein fragile X mental retardation protein (FMRP). Here, the authors show that FMRP sumoylation is required for regulating spine density and maturation.
format	article
author	Anouar Khayachi Carole Gwizdek Gwénola Poupon Damien Alcor Magda Chafai Frédéric Cassé Thomas Maurin Marta Prieto Alessandra Folci Fabienne De Graeve Sara Castagnola Romain Gautier Lenka Schorova Céline Loriol Marie Pronot Florence Besse Frédéric Brau Emmanuel Deval Barbara Bardoni Stéphane Martin
author_facet	Anouar Khayachi Carole Gwizdek Gwénola Poupon Damien Alcor Magda Chafai Frédéric Cassé Thomas Maurin Marta Prieto Alessandra Folci Fabienne De Graeve Sara Castagnola Romain Gautier Lenka Schorova Céline Loriol Marie Pronot Florence Besse Frédéric Brau Emmanuel Deval Barbara Bardoni Stéphane Martin
author_sort	Anouar Khayachi
title	Sumoylation regulates FMRP-mediated dendritic spine elimination and maturation
title_short	Sumoylation regulates FMRP-mediated dendritic spine elimination and maturation
title_full	Sumoylation regulates FMRP-mediated dendritic spine elimination and maturation
title_fullStr	Sumoylation regulates FMRP-mediated dendritic spine elimination and maturation
title_full_unstemmed	Sumoylation regulates FMRP-mediated dendritic spine elimination and maturation
title_sort	sumoylation regulates fmrp-mediated dendritic spine elimination and maturation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/57e3d66daa9b4a92b4183ee79455e739
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Sumoylation regulates FMRP-mediated dendritic spine elimination and maturation

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