ROLE OF ENDOTHELIAL CELLS IN REGULATION OF APOPTOSIS OF HIV-1 INFECTED CD4+ LYMPHOCYTES

Abstract. Vascular endothelial cells (VECs) are able to induce HIV1 replication in СD4+ Tcells, thus determining their resistance for apoptosis. The revealed facts are specific to EC/Tcell culture and are stipulated by the cellcell interactions between the VECs and HIV1 producing cells, thus being a...

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Auteurs principaux: S. V. Boichuk, I. G. Mustafin, M. V. Makarova
Format: article
Langue:RU
Publié: SPb RAACI 2014
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Accès en ligne:https://doaj.org/article/57e58a4672a5461e8e29a2f9b2058e8b
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Résumé:Abstract. Vascular endothelial cells (VECs) are able to induce HIV1 replication in СD4+ Tcells, thus determining their resistance for apoptosis. The revealed facts are specific to EC/Tcell culture and are stipulated by the cellcell interactions between the VECs and HIV1 producing cells, thus being a consequence of activation of ‘productively infected’ T cells.