Molecular epidemiology and HIV-1 variant evolution in Poland between 2015 and 2019

Abstract The occurrence of HIV-1 subtypes differs worldwide and within Europe, with non-B variants mainly found across different exposure groups. In this study, we investigated the distribution and temporal trends in HIV-1 subtype variability across Poland between 2015 and 2019. Sequences of the pol...

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Autores principales:	Karol Serwin, Anna Urbańska, Kaja Scheibe, Magdalena Witak-Jędra, Maria Jankowska, Maria Hlebowicz, Monika Bociąga-Jasik, Anna Kalinowska-Nowak, Martyna Biała, Hubert Ciepłucha, Władysław Łojewski, Anita Olczak, Elżbieta Jabłonowska, Aldona Kowalczuk-Kot, Błażej Rozpłochowski, Adam Witor, Miłosz Parczewski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/57ebb405ba7b40c8803ef69e003bae93
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spelling	oai:doaj.org-article:57ebb405ba7b40c8803ef69e003bae932021-12-02T17:08:35ZMolecular epidemiology and HIV-1 variant evolution in Poland between 2015 and 201910.1038/s41598-021-96125-w2045-2322https://doaj.org/article/57ebb405ba7b40c8803ef69e003bae932021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96125-whttps://doaj.org/toc/2045-2322Abstract The occurrence of HIV-1 subtypes differs worldwide and within Europe, with non-B variants mainly found across different exposure groups. In this study, we investigated the distribution and temporal trends in HIV-1 subtype variability across Poland between 2015 and 2019. Sequences of the pol gene fragment from 2518 individuals were used for the analysis of subtype prevalence. Subtype B was dominant (n = 2163, 85.90%). The proportion of subtype B-infected individuals decreased significantly, from 89.3% in 2015 to 80.3% in 2019. This was related to the increasing number of subtype A infections. In 355 (14.10%) sequences, non-B variants were identified. In 65 (2.58%) samples, recombinant forms (RFs) were noted. Unique recombinant forms (URFs) were found in 30 (1.19%) sequences. Three A/B recombinant clusters were identified of which two were A6/B mosaic viruses not previously described. Non-B clades were significantly more common among females (n = 81, 22.8%, p = 0.001) and heterosexually infected individuals (n = 45, 32.4%, p = 0.0031). The predominance of subtype B is evident, but the variability of HIV-1 in Poland is notable. Almost half of RFs (n = 65, 2.58%) was comprised of URFs (n = 30, 1.19%); thus those forms were common in the analyzed population. Hence, molecular surveillance of identified variants ensures recognition of HIV-1 evolution in Poland.Karol SerwinAnna UrbańskaKaja ScheibeMagdalena Witak-JędraMaria JankowskaMaria HlebowiczMonika Bociąga-JasikAnna Kalinowska-NowakMartyna BiałaHubert CiepłuchaWładysław ŁojewskiAnita OlczakElżbieta JabłonowskaAldona Kowalczuk-KotBłażej RozpłochowskiAdam WitorMiłosz ParczewskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Karol Serwin Anna Urbańska Kaja Scheibe Magdalena Witak-Jędra Maria Jankowska Maria Hlebowicz Monika Bociąga-Jasik Anna Kalinowska-Nowak Martyna Biała Hubert Ciepłucha Władysław Łojewski Anita Olczak Elżbieta Jabłonowska Aldona Kowalczuk-Kot Błażej Rozpłochowski Adam Witor Miłosz Parczewski Molecular epidemiology and HIV-1 variant evolution in Poland between 2015 and 2019
description	Abstract The occurrence of HIV-1 subtypes differs worldwide and within Europe, with non-B variants mainly found across different exposure groups. In this study, we investigated the distribution and temporal trends in HIV-1 subtype variability across Poland between 2015 and 2019. Sequences of the pol gene fragment from 2518 individuals were used for the analysis of subtype prevalence. Subtype B was dominant (n = 2163, 85.90%). The proportion of subtype B-infected individuals decreased significantly, from 89.3% in 2015 to 80.3% in 2019. This was related to the increasing number of subtype A infections. In 355 (14.10%) sequences, non-B variants were identified. In 65 (2.58%) samples, recombinant forms (RFs) were noted. Unique recombinant forms (URFs) were found in 30 (1.19%) sequences. Three A/B recombinant clusters were identified of which two were A6/B mosaic viruses not previously described. Non-B clades were significantly more common among females (n = 81, 22.8%, p = 0.001) and heterosexually infected individuals (n = 45, 32.4%, p = 0.0031). The predominance of subtype B is evident, but the variability of HIV-1 in Poland is notable. Almost half of RFs (n = 65, 2.58%) was comprised of URFs (n = 30, 1.19%); thus those forms were common in the analyzed population. Hence, molecular surveillance of identified variants ensures recognition of HIV-1 evolution in Poland.
format	article
author	Karol Serwin Anna Urbańska Kaja Scheibe Magdalena Witak-Jędra Maria Jankowska Maria Hlebowicz Monika Bociąga-Jasik Anna Kalinowska-Nowak Martyna Biała Hubert Ciepłucha Władysław Łojewski Anita Olczak Elżbieta Jabłonowska Aldona Kowalczuk-Kot Błażej Rozpłochowski Adam Witor Miłosz Parczewski
author_facet	Karol Serwin Anna Urbańska Kaja Scheibe Magdalena Witak-Jędra Maria Jankowska Maria Hlebowicz Monika Bociąga-Jasik Anna Kalinowska-Nowak Martyna Biała Hubert Ciepłucha Władysław Łojewski Anita Olczak Elżbieta Jabłonowska Aldona Kowalczuk-Kot Błażej Rozpłochowski Adam Witor Miłosz Parczewski
author_sort	Karol Serwin
title	Molecular epidemiology and HIV-1 variant evolution in Poland between 2015 and 2019
title_short	Molecular epidemiology and HIV-1 variant evolution in Poland between 2015 and 2019
title_full	Molecular epidemiology and HIV-1 variant evolution in Poland between 2015 and 2019
title_fullStr	Molecular epidemiology and HIV-1 variant evolution in Poland between 2015 and 2019
title_full_unstemmed	Molecular epidemiology and HIV-1 variant evolution in Poland between 2015 and 2019
title_sort	molecular epidemiology and hiv-1 variant evolution in poland between 2015 and 2019
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/57ebb405ba7b40c8803ef69e003bae93
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Molecular epidemiology and HIV-1 variant evolution in Poland between 2015 and 2019

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