Tumor innervation and clinical outcome in pancreatic cancer

Abstract Pancreatic cancer is a highly aggressive malignancy characterized by poor survival, recurrence after surgery and resistance to therapy. Nerves infiltrate the microenvironment of pancreatic cancers and contribute to tumor progression, however the clinicopathological significance of tumor inn...

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Autores principales:	Aysha Ferdoushi, Nathan Griffin, Mark Marsland, Xiaoyue Xu, Sam Faulkner, Fangfang Gao, Hui Liu, Simon J. King, James W. Denham, Dirk F. van Helden, Phillip Jobling, Chen Chen Jiang, Hubert Hondermarck
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/57ebd719b81a48ceb0a7183729c7fd08
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spelling	oai:doaj.org-article:57ebd719b81a48ceb0a7183729c7fd082021-12-02T13:26:24ZTumor innervation and clinical outcome in pancreatic cancer10.1038/s41598-021-86831-w2045-2322https://doaj.org/article/57ebd719b81a48ceb0a7183729c7fd082021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86831-whttps://doaj.org/toc/2045-2322Abstract Pancreatic cancer is a highly aggressive malignancy characterized by poor survival, recurrence after surgery and resistance to therapy. Nerves infiltrate the microenvironment of pancreatic cancers and contribute to tumor progression, however the clinicopathological significance of tumor innervation is unclear. In this study, the presence of nerves and their cross-sectional size were quantified by immunohistochemistry for the neuronal markers S-100, PGP9.5 and GAP-43 in a series of 99 pancreatic cancer cases versus 71 normal adjacent pancreatic tissues. A trend was observed between the presence of nerves in the tumor microenvironment of pancreatic cancer and worse overall patient survival (HR = 1.8, 95% CI 0.77–4.28, p = 0.08). The size of nerves, as measured by cross-sectional area, were significantly higher in pancreatic cancer than in the normal adjacent tissue (p = 0.002) and larger nerves were directly associated with worse patient survival (HR = 0.41, 95% CI 0.19–0.87, p = 0.04). In conclusion, this study suggests that the presence and size of nerves within the pancreatic cancer microenvironment are associated with tumor aggressiveness.Aysha FerdoushiNathan GriffinMark MarslandXiaoyue XuSam FaulknerFangfang GaoHui LiuSimon J. KingJames W. DenhamDirk F. van HeldenPhillip JoblingChen Chen JiangHubert HondermarckNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aysha Ferdoushi Nathan Griffin Mark Marsland Xiaoyue Xu Sam Faulkner Fangfang Gao Hui Liu Simon J. King James W. Denham Dirk F. van Helden Phillip Jobling Chen Chen Jiang Hubert Hondermarck Tumor innervation and clinical outcome in pancreatic cancer
description	Abstract Pancreatic cancer is a highly aggressive malignancy characterized by poor survival, recurrence after surgery and resistance to therapy. Nerves infiltrate the microenvironment of pancreatic cancers and contribute to tumor progression, however the clinicopathological significance of tumor innervation is unclear. In this study, the presence of nerves and their cross-sectional size were quantified by immunohistochemistry for the neuronal markers S-100, PGP9.5 and GAP-43 in a series of 99 pancreatic cancer cases versus 71 normal adjacent pancreatic tissues. A trend was observed between the presence of nerves in the tumor microenvironment of pancreatic cancer and worse overall patient survival (HR = 1.8, 95% CI 0.77–4.28, p = 0.08). The size of nerves, as measured by cross-sectional area, were significantly higher in pancreatic cancer than in the normal adjacent tissue (p = 0.002) and larger nerves were directly associated with worse patient survival (HR = 0.41, 95% CI 0.19–0.87, p = 0.04). In conclusion, this study suggests that the presence and size of nerves within the pancreatic cancer microenvironment are associated with tumor aggressiveness.
format	article
author	Aysha Ferdoushi Nathan Griffin Mark Marsland Xiaoyue Xu Sam Faulkner Fangfang Gao Hui Liu Simon J. King James W. Denham Dirk F. van Helden Phillip Jobling Chen Chen Jiang Hubert Hondermarck
author_facet	Aysha Ferdoushi Nathan Griffin Mark Marsland Xiaoyue Xu Sam Faulkner Fangfang Gao Hui Liu Simon J. King James W. Denham Dirk F. van Helden Phillip Jobling Chen Chen Jiang Hubert Hondermarck
author_sort	Aysha Ferdoushi
title	Tumor innervation and clinical outcome in pancreatic cancer
title_short	Tumor innervation and clinical outcome in pancreatic cancer
title_full	Tumor innervation and clinical outcome in pancreatic cancer
title_fullStr	Tumor innervation and clinical outcome in pancreatic cancer
title_full_unstemmed	Tumor innervation and clinical outcome in pancreatic cancer
title_sort	tumor innervation and clinical outcome in pancreatic cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/57ebd719b81a48ceb0a7183729c7fd08
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Tumor innervation and clinical outcome in pancreatic cancer

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