Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function

The epigenetic mechanisms regulating adipose tissue development are poorly understood. Here the authors show that reduction of H3K36 methylation in preadipocytes, both by H3.3K36M expression and depletion of H3K36 methyltransferase Nsd2, impairs adipogenesis by increasing H3K27me3.

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Autores principales:	Lenan Zhuang, Younghoon Jang, Young-Kwon Park, Ji-Eun Lee, Shalini Jain, Eugene Froimchuk, Aaron Broun, Chengyu Liu, Oksana Gavrilova, Kai Ge
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/57ecee0efcf14d1483faaa10d2a4a7bd
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spelling	oai:doaj.org-article:57ecee0efcf14d1483faaa10d2a4a7bd2021-12-02T17:31:45ZDepletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function10.1038/s41467-018-04127-62041-1723https://doaj.org/article/57ecee0efcf14d1483faaa10d2a4a7bd2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04127-6https://doaj.org/toc/2041-1723The epigenetic mechanisms regulating adipose tissue development are poorly understood. Here the authors show that reduction of H3K36 methylation in preadipocytes, both by H3.3K36M expression and depletion of H3K36 methyltransferase Nsd2, impairs adipogenesis by increasing H3K27me3.Lenan ZhuangYounghoon JangYoung-Kwon ParkJi-Eun LeeShalini JainEugene FroimchukAaron BrounChengyu LiuOksana GavrilovaKai GeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lenan Zhuang Younghoon Jang Young-Kwon Park Ji-Eun Lee Shalini Jain Eugene Froimchuk Aaron Broun Chengyu Liu Oksana Gavrilova Kai Ge Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function
description	The epigenetic mechanisms regulating adipose tissue development are poorly understood. Here the authors show that reduction of H3K36 methylation in preadipocytes, both by H3.3K36M expression and depletion of H3K36 methyltransferase Nsd2, impairs adipogenesis by increasing H3K27me3.
format	article
author	Lenan Zhuang Younghoon Jang Young-Kwon Park Ji-Eun Lee Shalini Jain Eugene Froimchuk Aaron Broun Chengyu Liu Oksana Gavrilova Kai Ge
author_facet	Lenan Zhuang Younghoon Jang Young-Kwon Park Ji-Eun Lee Shalini Jain Eugene Froimchuk Aaron Broun Chengyu Liu Oksana Gavrilova Kai Ge
author_sort	Lenan Zhuang
title	Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function
title_short	Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function
title_full	Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function
title_fullStr	Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function
title_full_unstemmed	Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function
title_sort	depletion of nsd2-mediated histone h3k36 methylation impairs adipose tissue development and function
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/57ecee0efcf14d1483faaa10d2a4a7bd
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Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function

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