Impact of COPD on COVID-19 prognosis: A nationwide population-based study in South Korea

Abstract Underlying chronic respiratory disease may be associated with the severity of coronavirus disease 2019 (COVID-19). This study investigated the impact of chronic obstructive pulmonary disease (COPD) on the risk for respiratory failure and mortality in COVID-19 patients. A nationwide retrospe...

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Autores principales:	Sang Chul Lee, Kang Ju Son, Chang Hoon Han, Seon Cheol Park, Ji Ye Jung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/57f223f4331c4a18bab87a96c6030897
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spelling	oai:doaj.org-article:57f223f4331c4a18bab87a96c60308972021-12-02T14:26:55ZImpact of COPD on COVID-19 prognosis: A nationwide population-based study in South Korea10.1038/s41598-021-83226-92045-2322https://doaj.org/article/57f223f4331c4a18bab87a96c60308972021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83226-9https://doaj.org/toc/2045-2322Abstract Underlying chronic respiratory disease may be associated with the severity of coronavirus disease 2019 (COVID-19). This study investigated the impact of chronic obstructive pulmonary disease (COPD) on the risk for respiratory failure and mortality in COVID-19 patients. A nationwide retrospective cohort study was conducted in 4610 patients (≥ 40 years old) infected with COVID-19 between January 20 and May 27, 2020, using data from the Ministry of Health and Welfare and Health Insurance Review and Assessment Service in Korea. The clinical course and various clinical features were compared between COPD and non-COPD patients, and the risks of respiratory failure and all-cause mortality in COPD patients were analyzed using a multivariate logistic regression model. Among 4610 COVID-19 patients, 4469 (96.9%) and 141 (3.1%) were categorized into the non-COPD and COPD groups, respectively. The COPD group had greater proportions of older (≥ 60 years old) (78.0% vs. 45.2%, P < 0.001) and male (52.5% vs. 36.6%, P < 0.001) patients than the non-COPD group. Relatively greater proportions of patients with COPD received intensive critical care (7.1% vs. 3.7%, P = 0.041) and mechanical ventilation (5.7% vs. 2.4%, P = 0.015). Multivariate analyses showed that COPD was not a risk factor for respiratory failure but was a significant independent risk factor for all-cause mortality (OR = 1.80, 95% CI 1.11–2.93) after adjustment for age, sex, and Charlson Comorbidity Index score. Among COVID-19 patients, relatively greater proportions of patients with COPD received mechanical ventilation and intensive critical care. COPD is an independent risk factor for all-cause mortality in COVID-19 patients in Korea.Sang Chul LeeKang Ju SonChang Hoon HanSeon Cheol ParkJi Ye JungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sang Chul Lee Kang Ju Son Chang Hoon Han Seon Cheol Park Ji Ye Jung Impact of COPD on COVID-19 prognosis: A nationwide population-based study in South Korea
description	Abstract Underlying chronic respiratory disease may be associated with the severity of coronavirus disease 2019 (COVID-19). This study investigated the impact of chronic obstructive pulmonary disease (COPD) on the risk for respiratory failure and mortality in COVID-19 patients. A nationwide retrospective cohort study was conducted in 4610 patients (≥ 40 years old) infected with COVID-19 between January 20 and May 27, 2020, using data from the Ministry of Health and Welfare and Health Insurance Review and Assessment Service in Korea. The clinical course and various clinical features were compared between COPD and non-COPD patients, and the risks of respiratory failure and all-cause mortality in COPD patients were analyzed using a multivariate logistic regression model. Among 4610 COVID-19 patients, 4469 (96.9%) and 141 (3.1%) were categorized into the non-COPD and COPD groups, respectively. The COPD group had greater proportions of older (≥ 60 years old) (78.0% vs. 45.2%, P < 0.001) and male (52.5% vs. 36.6%, P < 0.001) patients than the non-COPD group. Relatively greater proportions of patients with COPD received intensive critical care (7.1% vs. 3.7%, P = 0.041) and mechanical ventilation (5.7% vs. 2.4%, P = 0.015). Multivariate analyses showed that COPD was not a risk factor for respiratory failure but was a significant independent risk factor for all-cause mortality (OR = 1.80, 95% CI 1.11–2.93) after adjustment for age, sex, and Charlson Comorbidity Index score. Among COVID-19 patients, relatively greater proportions of patients with COPD received mechanical ventilation and intensive critical care. COPD is an independent risk factor for all-cause mortality in COVID-19 patients in Korea.
format	article
author	Sang Chul Lee Kang Ju Son Chang Hoon Han Seon Cheol Park Ji Ye Jung
author_facet	Sang Chul Lee Kang Ju Son Chang Hoon Han Seon Cheol Park Ji Ye Jung
author_sort	Sang Chul Lee
title	Impact of COPD on COVID-19 prognosis: A nationwide population-based study in South Korea
title_short	Impact of COPD on COVID-19 prognosis: A nationwide population-based study in South Korea
title_full	Impact of COPD on COVID-19 prognosis: A nationwide population-based study in South Korea
title_fullStr	Impact of COPD on COVID-19 prognosis: A nationwide population-based study in South Korea
title_full_unstemmed	Impact of COPD on COVID-19 prognosis: A nationwide population-based study in South Korea
title_sort	impact of copd on covid-19 prognosis: a nationwide population-based study in south korea
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/57f223f4331c4a18bab87a96c6030897
work_keys_str_mv	AT sangchullee impactofcopdoncovid19prognosisanationwidepopulationbasedstudyinsouthkorea AT kangjuson impactofcopdoncovid19prognosisanationwidepopulationbasedstudyinsouthkorea AT changhoonhan impactofcopdoncovid19prognosisanationwidepopulationbasedstudyinsouthkorea AT seoncheolpark impactofcopdoncovid19prognosisanationwidepopulationbasedstudyinsouthkorea AT jiyejung impactofcopdoncovid19prognosisanationwidepopulationbasedstudyinsouthkorea
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Impact of COPD on COVID-19 prognosis: A nationwide population-based study in South Korea

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