RNA sequence analysis of rat acute experimental pancreatitis with and without fatty liver: a gene expression profiling comparative study

Abstract Fatty liver (FL) is one of the risk factors for acute pancreatitis and is also indicative of a worse prognosis as compared to acute pancreatitis without fatty liver (AP). The aim of the present study was to analyze, at the hepatic level, the differentially expressed genes (DEGs) between acu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Qian Wang, Hongkai Yan, Gang Wang, Zhaoyan Qiu, Bin Bai, Shiqi Wang, Pengfei Yu, Quanxin Feng, Qingchuan Zhao, Xianli He, Chaoxu Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/57f277c34d764b0c81bd02b96f34dbed
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:57f277c34d764b0c81bd02b96f34dbed
record_format	dspace
spelling	oai:doaj.org-article:57f277c34d764b0c81bd02b96f34dbed2021-12-02T16:06:17ZRNA sequence analysis of rat acute experimental pancreatitis with and without fatty liver: a gene expression profiling comparative study10.1038/s41598-017-00821-52045-2322https://doaj.org/article/57f277c34d764b0c81bd02b96f34dbed2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00821-5https://doaj.org/toc/2045-2322Abstract Fatty liver (FL) is one of the risk factors for acute pancreatitis and is also indicative of a worse prognosis as compared to acute pancreatitis without fatty liver (AP). The aim of the present study was to analyze, at the hepatic level, the differentially expressed genes (DEGs) between acute pancreatitis with fatty liver (APFL) rats and AP rats. GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analyses of these DEGs indicated that PPARα signalling pathway and fatty acid degradation pathway may be involved in the pathological process of APFL, which indicated that fatty liver may aggravate pancreatitis through these pathways. Moreover, the excessive activation of JAK/STAT signaling pathway and toll-like receptor signaling pathway was also found in APFL group as shown in heat map. In conclusion, the inhibition of PPARα signaling pathway and the fatty acid degradation pathway may lead to the further disorder of lipid metabolism, which can aggravate pancreatitis.Qian WangHongkai YanGang WangZhaoyan QiuBin BaiShiqi WangPengfei YuQuanxin FengQingchuan ZhaoXianli HeChaoxu LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qian Wang Hongkai Yan Gang Wang Zhaoyan Qiu Bin Bai Shiqi Wang Pengfei Yu Quanxin Feng Qingchuan Zhao Xianli He Chaoxu Liu RNA sequence analysis of rat acute experimental pancreatitis with and without fatty liver: a gene expression profiling comparative study
description	Abstract Fatty liver (FL) is one of the risk factors for acute pancreatitis and is also indicative of a worse prognosis as compared to acute pancreatitis without fatty liver (AP). The aim of the present study was to analyze, at the hepatic level, the differentially expressed genes (DEGs) between acute pancreatitis with fatty liver (APFL) rats and AP rats. GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analyses of these DEGs indicated that PPARα signalling pathway and fatty acid degradation pathway may be involved in the pathological process of APFL, which indicated that fatty liver may aggravate pancreatitis through these pathways. Moreover, the excessive activation of JAK/STAT signaling pathway and toll-like receptor signaling pathway was also found in APFL group as shown in heat map. In conclusion, the inhibition of PPARα signaling pathway and the fatty acid degradation pathway may lead to the further disorder of lipid metabolism, which can aggravate pancreatitis.
format	article
author	Qian Wang Hongkai Yan Gang Wang Zhaoyan Qiu Bin Bai Shiqi Wang Pengfei Yu Quanxin Feng Qingchuan Zhao Xianli He Chaoxu Liu
author_facet	Qian Wang Hongkai Yan Gang Wang Zhaoyan Qiu Bin Bai Shiqi Wang Pengfei Yu Quanxin Feng Qingchuan Zhao Xianli He Chaoxu Liu
author_sort	Qian Wang
title	RNA sequence analysis of rat acute experimental pancreatitis with and without fatty liver: a gene expression profiling comparative study
title_short	RNA sequence analysis of rat acute experimental pancreatitis with and without fatty liver: a gene expression profiling comparative study
title_full	RNA sequence analysis of rat acute experimental pancreatitis with and without fatty liver: a gene expression profiling comparative study
title_fullStr	RNA sequence analysis of rat acute experimental pancreatitis with and without fatty liver: a gene expression profiling comparative study
title_full_unstemmed	RNA sequence analysis of rat acute experimental pancreatitis with and without fatty liver: a gene expression profiling comparative study
title_sort	rna sequence analysis of rat acute experimental pancreatitis with and without fatty liver: a gene expression profiling comparative study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/57f277c34d764b0c81bd02b96f34dbed
work_keys_str_mv	AT qianwang rnasequenceanalysisofratacuteexperimentalpancreatitiswithandwithoutfattyliverageneexpressionprofilingcomparativestudy AT hongkaiyan rnasequenceanalysisofratacuteexperimentalpancreatitiswithandwithoutfattyliverageneexpressionprofilingcomparativestudy AT gangwang rnasequenceanalysisofratacuteexperimentalpancreatitiswithandwithoutfattyliverageneexpressionprofilingcomparativestudy AT zhaoyanqiu rnasequenceanalysisofratacuteexperimentalpancreatitiswithandwithoutfattyliverageneexpressionprofilingcomparativestudy AT binbai rnasequenceanalysisofratacuteexperimentalpancreatitiswithandwithoutfattyliverageneexpressionprofilingcomparativestudy AT shiqiwang rnasequenceanalysisofratacuteexperimentalpancreatitiswithandwithoutfattyliverageneexpressionprofilingcomparativestudy AT pengfeiyu rnasequenceanalysisofratacuteexperimentalpancreatitiswithandwithoutfattyliverageneexpressionprofilingcomparativestudy AT quanxinfeng rnasequenceanalysisofratacuteexperimentalpancreatitiswithandwithoutfattyliverageneexpressionprofilingcomparativestudy AT qingchuanzhao rnasequenceanalysisofratacuteexperimentalpancreatitiswithandwithoutfattyliverageneexpressionprofilingcomparativestudy AT xianlihe rnasequenceanalysisofratacuteexperimentalpancreatitiswithandwithoutfattyliverageneexpressionprofilingcomparativestudy AT chaoxuliu rnasequenceanalysisofratacuteexperimentalpancreatitiswithandwithoutfattyliverageneexpressionprofilingcomparativestudy
_version_	1718385022450270208

RNA sequence analysis of rat acute experimental pancreatitis with and without fatty liver: a gene expression profiling comparative study

Ejemplares similares