Deconvolution of subcellular protrusion heterogeneity and the underlying actin regulator dynamics from live cell imaging

Cell protrusion dynamics are heterogeneous at the subcellular level, but current analyses operate at the cellular or ensemble level. Here the authors develop a computational framework to quantify subcellular protrusion phenotypes and reveal the underlying actin regulator dynamics at the leading edge...

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Autores principales:	Chuangqi Wang, Hee June Choi, Sung-Jin Kim, Aesha Desai, Namgyu Lee, Dohoon Kim, Yongho Bae, Kwonmoo Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/57f2a6977c8741f1bc29a2854eb06218
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spelling	oai:doaj.org-article:57f2a6977c8741f1bc29a2854eb062182021-12-02T17:33:03ZDeconvolution of subcellular protrusion heterogeneity and the underlying actin regulator dynamics from live cell imaging10.1038/s41467-018-04030-02041-1723https://doaj.org/article/57f2a6977c8741f1bc29a2854eb062182018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04030-0https://doaj.org/toc/2041-1723Cell protrusion dynamics are heterogeneous at the subcellular level, but current analyses operate at the cellular or ensemble level. Here the authors develop a computational framework to quantify subcellular protrusion phenotypes and reveal the underlying actin regulator dynamics at the leading edge.Chuangqi WangHee June ChoiSung-Jin KimAesha DesaiNamgyu LeeDohoon KimYongho BaeKwonmoo LeeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chuangqi Wang Hee June Choi Sung-Jin Kim Aesha Desai Namgyu Lee Dohoon Kim Yongho Bae Kwonmoo Lee Deconvolution of subcellular protrusion heterogeneity and the underlying actin regulator dynamics from live cell imaging
description	Cell protrusion dynamics are heterogeneous at the subcellular level, but current analyses operate at the cellular or ensemble level. Here the authors develop a computational framework to quantify subcellular protrusion phenotypes and reveal the underlying actin regulator dynamics at the leading edge.
format	article
author	Chuangqi Wang Hee June Choi Sung-Jin Kim Aesha Desai Namgyu Lee Dohoon Kim Yongho Bae Kwonmoo Lee
author_facet	Chuangqi Wang Hee June Choi Sung-Jin Kim Aesha Desai Namgyu Lee Dohoon Kim Yongho Bae Kwonmoo Lee
author_sort	Chuangqi Wang
title	Deconvolution of subcellular protrusion heterogeneity and the underlying actin regulator dynamics from live cell imaging
title_short	Deconvolution of subcellular protrusion heterogeneity and the underlying actin regulator dynamics from live cell imaging
title_full	Deconvolution of subcellular protrusion heterogeneity and the underlying actin regulator dynamics from live cell imaging
title_fullStr	Deconvolution of subcellular protrusion heterogeneity and the underlying actin regulator dynamics from live cell imaging
title_full_unstemmed	Deconvolution of subcellular protrusion heterogeneity and the underlying actin regulator dynamics from live cell imaging
title_sort	deconvolution of subcellular protrusion heterogeneity and the underlying actin regulator dynamics from live cell imaging
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/57f2a6977c8741f1bc29a2854eb06218
work_keys_str_mv	AT chuangqiwang deconvolutionofsubcellularprotrusionheterogeneityandtheunderlyingactinregulatordynamicsfromlivecellimaging AT heejunechoi deconvolutionofsubcellularprotrusionheterogeneityandtheunderlyingactinregulatordynamicsfromlivecellimaging AT sungjinkim deconvolutionofsubcellularprotrusionheterogeneityandtheunderlyingactinregulatordynamicsfromlivecellimaging AT aeshadesai deconvolutionofsubcellularprotrusionheterogeneityandtheunderlyingactinregulatordynamicsfromlivecellimaging AT namgyulee deconvolutionofsubcellularprotrusionheterogeneityandtheunderlyingactinregulatordynamicsfromlivecellimaging AT dohoonkim deconvolutionofsubcellularprotrusionheterogeneityandtheunderlyingactinregulatordynamicsfromlivecellimaging AT yonghobae deconvolutionofsubcellularprotrusionheterogeneityandtheunderlyingactinregulatordynamicsfromlivecellimaging AT kwonmoolee deconvolutionofsubcellularprotrusionheterogeneityandtheunderlyingactinregulatordynamicsfromlivecellimaging
_version_	1718380062317740032

Deconvolution of subcellular protrusion heterogeneity and the underlying actin regulator dynamics from live cell imaging

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