Reflected wave intensity increases based on aortic diameter after endovascular aortic therapy in a goat model

Abstract Reflected wave increases after endovascular aortic repair (EVAR) in patients with aortic aneurysm. This affects the left ventricular (LV) diastolic function and leads to a poor prognosis. This study aimed to evaluate the relationship between increased reflected wave amplitude and aortic dia...

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Autores principales:	Tomohiro Takano, Masumi Iwai-Takano, Yusuke Tsuboko, Yasuyuki Shiraishi, Tomoyuki Yambe, Takashi Igarashi, Hitoshi Yokoyama
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/57f3588c1f6040ea9f522b141bf33797
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spelling	oai:doaj.org-article:57f3588c1f6040ea9f522b141bf337972021-12-02T10:54:30ZReflected wave intensity increases based on aortic diameter after endovascular aortic therapy in a goat model10.1038/s41598-020-80920-y2045-2322https://doaj.org/article/57f3588c1f6040ea9f522b141bf337972021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80920-yhttps://doaj.org/toc/2045-2322Abstract Reflected wave increases after endovascular aortic repair (EVAR) in patients with aortic aneurysm. This affects the left ventricular (LV) diastolic function and leads to a poor prognosis. This study aimed to evaluate the relationship between increased reflected wave amplitude and aortic diameter after EVAR. EVAR was performed in seven healthy goats. We assessed wave intensity (WI), aortic diameter, and stiffness parameter β. Moreover, we evaluated the relationship between negative reflected wave (NW, reflected waves toward the heart from the periphery by WI) and other parameters after EVAR. Results showed an increase in stiffness parameter β (3.5 ± 0.3 vs 15.9 ± 4.7, p = 0.018) and a decrease in the change of aortic diameter (6.9 ± 0.7 vs 2.7 ± 0.4%, p = 0.018) after EVAR. The NW was significantly amplified after EVAR from baseline (−589.8 ± 143.4 to − 1192.3 ± 303.7 mmHg-m/sec3, p = 0.043). The NW showed a significant correlation with maximum aortic diameter (R = 0.707, p = 0.038) and minimum aortic diameter (R = 0.724, p = 0.033). The reflected wave was enhanced after EVAR and was correlated to the aortic diameter at the stent-graft site. It is important to consider that patients with smaller aortic diameters in landing zone who undergo EVAR may develop LV dysfunction.Tomohiro TakanoMasumi Iwai-TakanoYusuke TsubokoYasuyuki ShiraishiTomoyuki YambeTakashi IgarashiHitoshi YokoyamaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tomohiro Takano Masumi Iwai-Takano Yusuke Tsuboko Yasuyuki Shiraishi Tomoyuki Yambe Takashi Igarashi Hitoshi Yokoyama Reflected wave intensity increases based on aortic diameter after endovascular aortic therapy in a goat model
description	Abstract Reflected wave increases after endovascular aortic repair (EVAR) in patients with aortic aneurysm. This affects the left ventricular (LV) diastolic function and leads to a poor prognosis. This study aimed to evaluate the relationship between increased reflected wave amplitude and aortic diameter after EVAR. EVAR was performed in seven healthy goats. We assessed wave intensity (WI), aortic diameter, and stiffness parameter β. Moreover, we evaluated the relationship between negative reflected wave (NW, reflected waves toward the heart from the periphery by WI) and other parameters after EVAR. Results showed an increase in stiffness parameter β (3.5 ± 0.3 vs 15.9 ± 4.7, p = 0.018) and a decrease in the change of aortic diameter (6.9 ± 0.7 vs 2.7 ± 0.4%, p = 0.018) after EVAR. The NW was significantly amplified after EVAR from baseline (−589.8 ± 143.4 to − 1192.3 ± 303.7 mmHg-m/sec3, p = 0.043). The NW showed a significant correlation with maximum aortic diameter (R = 0.707, p = 0.038) and minimum aortic diameter (R = 0.724, p = 0.033). The reflected wave was enhanced after EVAR and was correlated to the aortic diameter at the stent-graft site. It is important to consider that patients with smaller aortic diameters in landing zone who undergo EVAR may develop LV dysfunction.
format	article
author	Tomohiro Takano Masumi Iwai-Takano Yusuke Tsuboko Yasuyuki Shiraishi Tomoyuki Yambe Takashi Igarashi Hitoshi Yokoyama
author_facet	Tomohiro Takano Masumi Iwai-Takano Yusuke Tsuboko Yasuyuki Shiraishi Tomoyuki Yambe Takashi Igarashi Hitoshi Yokoyama
author_sort	Tomohiro Takano
title	Reflected wave intensity increases based on aortic diameter after endovascular aortic therapy in a goat model
title_short	Reflected wave intensity increases based on aortic diameter after endovascular aortic therapy in a goat model
title_full	Reflected wave intensity increases based on aortic diameter after endovascular aortic therapy in a goat model
title_fullStr	Reflected wave intensity increases based on aortic diameter after endovascular aortic therapy in a goat model
title_full_unstemmed	Reflected wave intensity increases based on aortic diameter after endovascular aortic therapy in a goat model
title_sort	reflected wave intensity increases based on aortic diameter after endovascular aortic therapy in a goat model
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/57f3588c1f6040ea9f522b141bf33797
work_keys_str_mv	AT tomohirotakano reflectedwaveintensityincreasesbasedonaorticdiameterafterendovascularaortictherapyinagoatmodel AT masumiiwaitakano reflectedwaveintensityincreasesbasedonaorticdiameterafterendovascularaortictherapyinagoatmodel AT yusuketsuboko reflectedwaveintensityincreasesbasedonaorticdiameterafterendovascularaortictherapyinagoatmodel AT yasuyukishiraishi reflectedwaveintensityincreasesbasedonaorticdiameterafterendovascularaortictherapyinagoatmodel AT tomoyukiyambe reflectedwaveintensityincreasesbasedonaorticdiameterafterendovascularaortictherapyinagoatmodel AT takashiigarashi reflectedwaveintensityincreasesbasedonaorticdiameterafterendovascularaortictherapyinagoatmodel AT hitoshiyokoyama reflectedwaveintensityincreasesbasedonaorticdiameterafterendovascularaortictherapyinagoatmodel
_version_	1718396470850224128

Reflected wave intensity increases based on aortic diameter after endovascular aortic therapy in a goat model

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