Analysis of the distribution of magnetic fluid inside tumors by a giant magnetoresistance probe.

Magnetic fluid hyperthermia (MFH) therapy uses the magnetic component of electromagnetic fields in the radiofrequency spectrum to couple energy to magnetic nanoparticles inside tumors. In MFH therapy, magnetic fluid is injected into tumors and an alternating current (AC) magnetic flux is applied to...

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Autores principales:	Chinthaka P Gooneratne, Adam Kurnicki, Sotoshi Yamada, Subhas C Mukhopadhyay, Jürgen Kosel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/57f4972e3240484993500b82c5f73378
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spelling	oai:doaj.org-article:57f4972e3240484993500b82c5f733782021-11-18T08:44:10ZAnalysis of the distribution of magnetic fluid inside tumors by a giant magnetoresistance probe.1932-620310.1371/journal.pone.0081227https://doaj.org/article/57f4972e3240484993500b82c5f733782013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24312280/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Magnetic fluid hyperthermia (MFH) therapy uses the magnetic component of electromagnetic fields in the radiofrequency spectrum to couple energy to magnetic nanoparticles inside tumors. In MFH therapy, magnetic fluid is injected into tumors and an alternating current (AC) magnetic flux is applied to heat the magnetic fluid- filled tumor. If the temperature can be maintained at the therapeutic threshold of 42 °C for 30 minutes or more, the tumor cells can be destroyed. Analyzing the distribution of the magnetic fluid injected into tumors prior to the heating step in MFH therapy is an essential criterion for homogenous heating of tumors, since a decision can then be taken on the strength and localization of the applied external AC magnetic flux density needed to destroy the tumor without affecting healthy cells. This paper proposes a methodology for analyzing the distribution of magnetic fluid in a tumor by a specifically designed giant magnetoresistance (GMR) probe prior to MFH heat treatment. Experimental results analyzing the distribution of magnetic fluid suggest that different magnetic fluid weight densities could be estimated inside a single tumor by the GMR probe.Chinthaka P GooneratneAdam KurnickiSotoshi YamadaSubhas C MukhopadhyayJürgen KoselPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e81227 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chinthaka P Gooneratne Adam Kurnicki Sotoshi Yamada Subhas C Mukhopadhyay Jürgen Kosel Analysis of the distribution of magnetic fluid inside tumors by a giant magnetoresistance probe.
description	Magnetic fluid hyperthermia (MFH) therapy uses the magnetic component of electromagnetic fields in the radiofrequency spectrum to couple energy to magnetic nanoparticles inside tumors. In MFH therapy, magnetic fluid is injected into tumors and an alternating current (AC) magnetic flux is applied to heat the magnetic fluid- filled tumor. If the temperature can be maintained at the therapeutic threshold of 42 °C for 30 minutes or more, the tumor cells can be destroyed. Analyzing the distribution of the magnetic fluid injected into tumors prior to the heating step in MFH therapy is an essential criterion for homogenous heating of tumors, since a decision can then be taken on the strength and localization of the applied external AC magnetic flux density needed to destroy the tumor without affecting healthy cells. This paper proposes a methodology for analyzing the distribution of magnetic fluid in a tumor by a specifically designed giant magnetoresistance (GMR) probe prior to MFH heat treatment. Experimental results analyzing the distribution of magnetic fluid suggest that different magnetic fluid weight densities could be estimated inside a single tumor by the GMR probe.
format	article
author	Chinthaka P Gooneratne Adam Kurnicki Sotoshi Yamada Subhas C Mukhopadhyay Jürgen Kosel
author_facet	Chinthaka P Gooneratne Adam Kurnicki Sotoshi Yamada Subhas C Mukhopadhyay Jürgen Kosel
author_sort	Chinthaka P Gooneratne
title	Analysis of the distribution of magnetic fluid inside tumors by a giant magnetoresistance probe.
title_short	Analysis of the distribution of magnetic fluid inside tumors by a giant magnetoresistance probe.
title_full	Analysis of the distribution of magnetic fluid inside tumors by a giant magnetoresistance probe.
title_fullStr	Analysis of the distribution of magnetic fluid inside tumors by a giant magnetoresistance probe.
title_full_unstemmed	Analysis of the distribution of magnetic fluid inside tumors by a giant magnetoresistance probe.
title_sort	analysis of the distribution of magnetic fluid inside tumors by a giant magnetoresistance probe.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/57f4972e3240484993500b82c5f73378
work_keys_str_mv	AT chinthakapgooneratne analysisofthedistributionofmagneticfluidinsidetumorsbyagiantmagnetoresistanceprobe AT adamkurnicki analysisofthedistributionofmagneticfluidinsidetumorsbyagiantmagnetoresistanceprobe AT sotoshiyamada analysisofthedistributionofmagneticfluidinsidetumorsbyagiantmagnetoresistanceprobe AT subhascmukhopadhyay analysisofthedistributionofmagneticfluidinsidetumorsbyagiantmagnetoresistanceprobe AT jurgenkosel analysisofthedistributionofmagneticfluidinsidetumorsbyagiantmagnetoresistanceprobe
_version_	1718421384035565568

Analysis of the distribution of magnetic fluid inside tumors by a giant magnetoresistance probe.

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