Characteristics of randomized trials published in Latin America and the Caribbean according to funding source.

<h4>Introduction</h4>Few studies have assessed the nature and quality of randomized controlled trials (RCTs) in Latin America and the Caribbean (LAC).<h4>Methods and findings</h4>The aims of this systematic review are to evaluate the characteristics (including the risk of bia...

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Autores principales:	Ludovic Reveiz, Stephanie Sangalang, Demian Glujovsky, Carlos E Pinzon, Claudia Asenjo Lobos, Marcela Cortes, Martin Cañón, Ariel Bardach, Xavier Bonfill
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/57f64bc562ad4d35806c84bb171fea83
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spelling	oai:doaj.org-article:57f64bc562ad4d35806c84bb171fea832021-11-18T07:57:38ZCharacteristics of randomized trials published in Latin America and the Caribbean according to funding source.1932-620310.1371/journal.pone.0056410https://doaj.org/article/57f64bc562ad4d35806c84bb171fea832013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23418566/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Introduction</h4>Few studies have assessed the nature and quality of randomized controlled trials (RCTs) in Latin America and the Caribbean (LAC).<h4>Methods and findings</h4>The aims of this systematic review are to evaluate the characteristics (including the risk of bias assessment) of RCT conducted in LAC according to funding source. A review of RCTs published in 2010 in which the author's affiliation was from LAC was performed in PubMed and LILACS. Two reviewers independently extracted data and assessed the risk of bias. The primary outcomes were risk of bias assessment and funding source. A total of 1,695 references were found in PubMed and LILACS databases, of which 526 were RCTs (N = 73.513 participants). English was the dominant publication language (93%) and most of the RCTs were published in non-LAC journals (84.2%). Only five of the 19 identified countries accounted for nearly 95% of all RCTs conducted in the region (Brazil 70.9%, Mexico 10.1%, Argentina 5.9%, Colombia 3.8%, and Chile 3.4%). Few RCTs covered priority areas related with Millennium Development Goals like maternal health (6.7%) or high priority infectious diseases (3.8%). Regarding children, 3.6% and 0.4% RCT evaluated nutrition and diarrhea interventions respectively but none pneumonia. As a comparison, aesthetic and sport related interventions account for 4.6% of all trials. A random sample of RCTs (n = 358) was assessed for funding source: exclusively public (33.8%); private (e.g. pharmaceutical company) (15.3%); other (e.g. mixed, NGO) (15.1%); no funding (35.8%). Overall assessments for risk of bias showed no statistically significant differences between RCTs and type of funding source. Statistically significant differences favoring private and others type of funding was found when assessing trial registration and conflict of interest reporting.<h4>Conclusion</h4>Findings of this study could be used to provide more direction for future research to facilitate innovation, improve health outcomes or address priority health problems.Ludovic ReveizStephanie SangalangDemian GlujovskyCarlos E PinzonClaudia Asenjo LobosMarcela CortesMartin CañónAriel BardachXavier BonfillPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e56410 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ludovic Reveiz Stephanie Sangalang Demian Glujovsky Carlos E Pinzon Claudia Asenjo Lobos Marcela Cortes Martin Cañón Ariel Bardach Xavier Bonfill Characteristics of randomized trials published in Latin America and the Caribbean according to funding source.
description	<h4>Introduction</h4>Few studies have assessed the nature and quality of randomized controlled trials (RCTs) in Latin America and the Caribbean (LAC).<h4>Methods and findings</h4>The aims of this systematic review are to evaluate the characteristics (including the risk of bias assessment) of RCT conducted in LAC according to funding source. A review of RCTs published in 2010 in which the author's affiliation was from LAC was performed in PubMed and LILACS. Two reviewers independently extracted data and assessed the risk of bias. The primary outcomes were risk of bias assessment and funding source. A total of 1,695 references were found in PubMed and LILACS databases, of which 526 were RCTs (N = 73.513 participants). English was the dominant publication language (93%) and most of the RCTs were published in non-LAC journals (84.2%). Only five of the 19 identified countries accounted for nearly 95% of all RCTs conducted in the region (Brazil 70.9%, Mexico 10.1%, Argentina 5.9%, Colombia 3.8%, and Chile 3.4%). Few RCTs covered priority areas related with Millennium Development Goals like maternal health (6.7%) or high priority infectious diseases (3.8%). Regarding children, 3.6% and 0.4% RCT evaluated nutrition and diarrhea interventions respectively but none pneumonia. As a comparison, aesthetic and sport related interventions account for 4.6% of all trials. A random sample of RCTs (n = 358) was assessed for funding source: exclusively public (33.8%); private (e.g. pharmaceutical company) (15.3%); other (e.g. mixed, NGO) (15.1%); no funding (35.8%). Overall assessments for risk of bias showed no statistically significant differences between RCTs and type of funding source. Statistically significant differences favoring private and others type of funding was found when assessing trial registration and conflict of interest reporting.<h4>Conclusion</h4>Findings of this study could be used to provide more direction for future research to facilitate innovation, improve health outcomes or address priority health problems.
format	article
author	Ludovic Reveiz Stephanie Sangalang Demian Glujovsky Carlos E Pinzon Claudia Asenjo Lobos Marcela Cortes Martin Cañón Ariel Bardach Xavier Bonfill
author_facet	Ludovic Reveiz Stephanie Sangalang Demian Glujovsky Carlos E Pinzon Claudia Asenjo Lobos Marcela Cortes Martin Cañón Ariel Bardach Xavier Bonfill
author_sort	Ludovic Reveiz
title	Characteristics of randomized trials published in Latin America and the Caribbean according to funding source.
title_short	Characteristics of randomized trials published in Latin America and the Caribbean according to funding source.
title_full	Characteristics of randomized trials published in Latin America and the Caribbean according to funding source.
title_fullStr	Characteristics of randomized trials published in Latin America and the Caribbean according to funding source.
title_full_unstemmed	Characteristics of randomized trials published in Latin America and the Caribbean according to funding source.
title_sort	characteristics of randomized trials published in latin america and the caribbean according to funding source.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/57f64bc562ad4d35806c84bb171fea83
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Characteristics of randomized trials published in Latin America and the Caribbean according to funding source.

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