Late- versus early-onset geriatric depression in a memory research center

Carol Dillon1, Ricardo F Allegri2, Cecilia M Serrano1, M&oacute;nica Iturry1, Pablo Salgado1, Frank B Glaser1, Fernando&nbsp;E Taragano21Memory Research Center, Department of Neurology, Hospital General Abel Zubizarreta, GCBA Buenos Aires, Argentina; 2Department of Neuropsychology (S...

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Autores principales:	Carol Dillon, Ricardo F Allegri, Cecilia M Serrano, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/57fbeeb033ba49b6a571ba6ea3cc60d5
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spelling	oai:doaj.org-article:57fbeeb033ba49b6a571ba6ea3cc60d52021-12-02T04:24:40ZLate- versus early-onset geriatric depression in a memory research center1176-63281178-2021https://doaj.org/article/57fbeeb033ba49b6a571ba6ea3cc60d52009-10-01T00:00:00Zhttp://www.dovepress.com/late--versus-early-onset-geriatric-depression-in-a-memory-research-cen-a3615https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Carol Dillon1, Ricardo F Allegri2, Cecilia M Serrano1, M&oacute;nica Iturry1, Pablo Salgado1, Frank B Glaser1, Fernando&nbsp;E Taragano21Memory Research Center, Department of Neurology, Hospital General Abel Zubizarreta, GCBA Buenos Aires, Argentina; 2Department of Neuropsychology (SIREN), CEMIC University, Buenos Aires, ArgentinaObjective: To contrast early-onset (&lt;60 years) and late-onset (&gt;60 years) depression in geriatric patients by evaluating differences in cognition, vascular comorbidity and sociological risk factors. Both patient groups were compared with normal subjects.Materials and methods: We recruited 76 patients with depressive symptoms (37 late onset and 39 early onset) and 17 normal controls matched by age and educational level. All subjects were assessed using a semistructured neuropsychiatric interview and an extensive neuropsychological battery. Vascular and sociological risk factors were also evaluated.Results: We found a significant variation in performance between depressive patients and normal controls in most cognitive functions, especially memory (P &lt; 0.0001), semantic fluency (P &lt; 0.0001), verbal fluency, and digit-symbol (P &lt; 0.0001). Late-onset depression patients scored lower and exhibited more severe impairment in memory domains than early-onset depression patients (P &lt; 0.05). Cholesterol levels and marital status were significantly (P &lt; 0.05) different between the depressive groups. Both depressed groups (early- and lateonset) were more inactive than controls (P &lt; 0.05; odds ratio: 6.02).Conclusion: Geriatric depression may be a manifestation of brain degeneration, and the initial symptom of a dementia. It is important to consider this in the treatment of patients that exhibit late-onset depressive symptoms.Keywords: early- and late-onset depression, geriatrics, cognition Carol DillonRicardo F AllegriCecilia M Serranoet alDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2009, Iss default, Pp 517-526 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Carol Dillon Ricardo F Allegri Cecilia M Serrano et al Late- versus early-onset geriatric depression in a memory research center
description	Carol Dillon1, Ricardo F Allegri2, Cecilia M Serrano1, M&oacute;nica Iturry1, Pablo Salgado1, Frank B Glaser1, Fernando&nbsp;E Taragano21Memory Research Center, Department of Neurology, Hospital General Abel Zubizarreta, GCBA Buenos Aires, Argentina; 2Department of Neuropsychology (SIREN), CEMIC University, Buenos Aires, ArgentinaObjective: To contrast early-onset (&lt;60 years) and late-onset (&gt;60 years) depression in geriatric patients by evaluating differences in cognition, vascular comorbidity and sociological risk factors. Both patient groups were compared with normal subjects.Materials and methods: We recruited 76 patients with depressive symptoms (37 late onset and 39 early onset) and 17 normal controls matched by age and educational level. All subjects were assessed using a semistructured neuropsychiatric interview and an extensive neuropsychological battery. Vascular and sociological risk factors were also evaluated.Results: We found a significant variation in performance between depressive patients and normal controls in most cognitive functions, especially memory (P &lt; 0.0001), semantic fluency (P &lt; 0.0001), verbal fluency, and digit-symbol (P &lt; 0.0001). Late-onset depression patients scored lower and exhibited more severe impairment in memory domains than early-onset depression patients (P &lt; 0.05). Cholesterol levels and marital status were significantly (P &lt; 0.05) different between the depressive groups. Both depressed groups (early- and lateonset) were more inactive than controls (P &lt; 0.05; odds ratio: 6.02).Conclusion: Geriatric depression may be a manifestation of brain degeneration, and the initial symptom of a dementia. It is important to consider this in the treatment of patients that exhibit late-onset depressive symptoms.Keywords: early- and late-onset depression, geriatrics, cognition
format	article
author	Carol Dillon Ricardo F Allegri Cecilia M Serrano et al
author_facet	Carol Dillon Ricardo F Allegri Cecilia M Serrano et al
author_sort	Carol Dillon
title	Late- versus early-onset geriatric depression in a memory research center
title_short	Late- versus early-onset geriatric depression in a memory research center
title_full	Late- versus early-onset geriatric depression in a memory research center
title_fullStr	Late- versus early-onset geriatric depression in a memory research center
title_full_unstemmed	Late- versus early-onset geriatric depression in a memory research center
title_sort	late- versus early-onset geriatric depression in a memory research center
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/57fbeeb033ba49b6a571ba6ea3cc60d5
work_keys_str_mv	AT caroldillon lateversusearlyonsetgeriatricdepressioninamemoryresearchcenter AT ricardofallegri lateversusearlyonsetgeriatricdepressioninamemoryresearchcenter AT ceciliamserrano lateversusearlyonsetgeriatricdepressioninamemoryresearchcenter AT etal lateversusearlyonsetgeriatricdepressioninamemoryresearchcenter
_version_	1718401245076520960

Late- versus early-onset geriatric depression in a memory research center

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