Inter-eye comparison of retinal oximetry and vessel caliber between eyes with asymmetrical glaucoma severity in different glaucoma subtypes

Clarissa Shu Ming Cheng,1,2 Yi Fang Lee,2 Charles Ong,3 Zhu Li Yap,2 Andrew Tsai,2 Aditi Mohla,2 Monisha E Nongpiur,4 Tin Aung,2,4 Shamira A Perera2,4 1Department of Ophthalmology, Tan Tock Seng Hospital, 2Department of Ophthalmology, Singapore National Eye Centre, 3Yong Loo Lin School of Medicine,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Cheng CS, Lee YF, Ong C, Yap ZL, Tsai A, Mohla A, Nongpiur ME, Aung T, Perera SA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Glaucoma oximetry retinal vessels imaging Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/57fc52f54c56450792f83a641233511f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:57fc52f54c56450792f83a641233511f
record_format	dspace
spelling	oai:doaj.org-article:57fc52f54c56450792f83a641233511f2021-12-02T00:31:07ZInter-eye comparison of retinal oximetry and vessel caliber between eyes with asymmetrical glaucoma severity in different glaucoma subtypes1177-5483https://doaj.org/article/57fc52f54c56450792f83a641233511f2016-07-01T00:00:00Zhttps://www.dovepress.com/inter-eye-comparison-of-retinal-oximetry-and-vessel-caliber-between-ey-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Clarissa Shu Ming Cheng,1,2 Yi Fang Lee,2 Charles Ong,3 Zhu Li Yap,2 Andrew Tsai,2 Aditi Mohla,2 Monisha E Nongpiur,4 Tin Aung,2,4 Shamira A Perera2,4 1Department of Ophthalmology, Tan Tock Seng Hospital, 2Department of Ophthalmology, Singapore National Eye Centre, 3Yong Loo Lin School of Medicine, National University of Singapore, 4Singapore Eye Research Institute, Singapore National Eye Centre, Singapore Background: To compare retinal vessel oxygenation and vessel caliber in primary angle-closure glaucoma (PACG), primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), and normal controls, as well as between eyes of asymmetrical glaucoma severity.Methods: This was a prospective, cross-sectional study. The 159 subjects (PACG, n=39; POAG, n=41; NTG, n=41; normal controls, n=38) underwent retinal oxygen saturation measurements using the Oxymap T1 Retinal Oximeter, optical coherence tomography, and Humphrey visual field testing. Retinal oxygen saturation and vessel diameter were compared between the glaucoma groups and normal controls, as well as between eyes of asymmetrical glaucoma severity. Kruskal–Wallis test was performed for comparison among different subtypes of glaucoma. Wilcoxon signed-rank test was used to compare the inter-eye differences.Results: Compared to normal controls, arteriolar oxygen saturation was increased in PACG eyes (P=0.048) but not in POAG or NTG eyes. There were no significant differences in oxygen saturation in venules or arteriovenous (AV) difference in all three glaucoma groups. Venular diameter was significantly reduced in all glaucoma groups compared to normal controls (P<0.001), but no such change was observed in arteriolar diameter (P=0.10). When comparing between eyes of asymmetrical glaucoma severity, arteriolar oxygen saturation (P=0.03) and AV difference (P=0.04) were significantly higher, while arteriolar diameter was significantly lower (P=0.001) in the worse eye in PACG group. There were no significant differences in oximetric parameters or vessel calibers between the worse and the better eyes in POAG and NTG groups. Conclusion: Eyes with PACG showed increased arteriolar oxygen saturation and increased AV difference. This was not observed in POAG and NTG eyes. Arteriolar diameter in PACG and venular diameter in all three glaucoma groups were reduced. The difference observed in PACG eyes may be due to an increased metabolic demand in the disease process compared to open-angle glaucoma. Keywords: glaucoma, oximetry, retinal vessels, imagingCheng CSLee YFOng CYap ZLTsai AMohla ANongpiur MEAung TPerera SADove Medical PressarticleGlaucomaoximetryretinal vesselsimagingOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2016, Iss Issue 1, Pp 1315-1321 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Glaucoma oximetry retinal vessels imaging Ophthalmology RE1-994
spellingShingle	Glaucoma oximetry retinal vessels imaging Ophthalmology RE1-994 Cheng CS Lee YF Ong C Yap ZL Tsai A Mohla A Nongpiur ME Aung T Perera SA Inter-eye comparison of retinal oximetry and vessel caliber between eyes with asymmetrical glaucoma severity in different glaucoma subtypes
description	Clarissa Shu Ming Cheng,1,2 Yi Fang Lee,2 Charles Ong,3 Zhu Li Yap,2 Andrew Tsai,2 Aditi Mohla,2 Monisha E Nongpiur,4 Tin Aung,2,4 Shamira A Perera2,4 1Department of Ophthalmology, Tan Tock Seng Hospital, 2Department of Ophthalmology, Singapore National Eye Centre, 3Yong Loo Lin School of Medicine, National University of Singapore, 4Singapore Eye Research Institute, Singapore National Eye Centre, Singapore Background: To compare retinal vessel oxygenation and vessel caliber in primary angle-closure glaucoma (PACG), primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), and normal controls, as well as between eyes of asymmetrical glaucoma severity.Methods: This was a prospective, cross-sectional study. The 159 subjects (PACG, n=39; POAG, n=41; NTG, n=41; normal controls, n=38) underwent retinal oxygen saturation measurements using the Oxymap T1 Retinal Oximeter, optical coherence tomography, and Humphrey visual field testing. Retinal oxygen saturation and vessel diameter were compared between the glaucoma groups and normal controls, as well as between eyes of asymmetrical glaucoma severity. Kruskal–Wallis test was performed for comparison among different subtypes of glaucoma. Wilcoxon signed-rank test was used to compare the inter-eye differences.Results: Compared to normal controls, arteriolar oxygen saturation was increased in PACG eyes (P=0.048) but not in POAG or NTG eyes. There were no significant differences in oxygen saturation in venules or arteriovenous (AV) difference in all three glaucoma groups. Venular diameter was significantly reduced in all glaucoma groups compared to normal controls (P<0.001), but no such change was observed in arteriolar diameter (P=0.10). When comparing between eyes of asymmetrical glaucoma severity, arteriolar oxygen saturation (P=0.03) and AV difference (P=0.04) were significantly higher, while arteriolar diameter was significantly lower (P=0.001) in the worse eye in PACG group. There were no significant differences in oximetric parameters or vessel calibers between the worse and the better eyes in POAG and NTG groups. Conclusion: Eyes with PACG showed increased arteriolar oxygen saturation and increased AV difference. This was not observed in POAG and NTG eyes. Arteriolar diameter in PACG and venular diameter in all three glaucoma groups were reduced. The difference observed in PACG eyes may be due to an increased metabolic demand in the disease process compared to open-angle glaucoma. Keywords: glaucoma, oximetry, retinal vessels, imaging
format	article
author	Cheng CS Lee YF Ong C Yap ZL Tsai A Mohla A Nongpiur ME Aung T Perera SA
author_facet	Cheng CS Lee YF Ong C Yap ZL Tsai A Mohla A Nongpiur ME Aung T Perera SA
author_sort	Cheng CS
title	Inter-eye comparison of retinal oximetry and vessel caliber between eyes with asymmetrical glaucoma severity in different glaucoma subtypes
title_short	Inter-eye comparison of retinal oximetry and vessel caliber between eyes with asymmetrical glaucoma severity in different glaucoma subtypes
title_full	Inter-eye comparison of retinal oximetry and vessel caliber between eyes with asymmetrical glaucoma severity in different glaucoma subtypes
title_fullStr	Inter-eye comparison of retinal oximetry and vessel caliber between eyes with asymmetrical glaucoma severity in different glaucoma subtypes
title_full_unstemmed	Inter-eye comparison of retinal oximetry and vessel caliber between eyes with asymmetrical glaucoma severity in different glaucoma subtypes
title_sort	inter-eye comparison of retinal oximetry and vessel caliber between eyes with asymmetrical glaucoma severity in different glaucoma subtypes
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/57fc52f54c56450792f83a641233511f
work_keys_str_mv	AT chengcs intereyecomparisonofretinaloximetryandvesselcaliberbetweeneyeswithasymmetricalglaucomaseverityindifferentglaucomasubtypes AT leeyf intereyecomparisonofretinaloximetryandvesselcaliberbetweeneyeswithasymmetricalglaucomaseverityindifferentglaucomasubtypes AT ongc intereyecomparisonofretinaloximetryandvesselcaliberbetweeneyeswithasymmetricalglaucomaseverityindifferentglaucomasubtypes AT yapzl intereyecomparisonofretinaloximetryandvesselcaliberbetweeneyeswithasymmetricalglaucomaseverityindifferentglaucomasubtypes AT tsaia intereyecomparisonofretinaloximetryandvesselcaliberbetweeneyeswithasymmetricalglaucomaseverityindifferentglaucomasubtypes AT mohlaa intereyecomparisonofretinaloximetryandvesselcaliberbetweeneyeswithasymmetricalglaucomaseverityindifferentglaucomasubtypes AT nongpiurme intereyecomparisonofretinaloximetryandvesselcaliberbetweeneyeswithasymmetricalglaucomaseverityindifferentglaucomasubtypes AT aungt intereyecomparisonofretinaloximetryandvesselcaliberbetweeneyeswithasymmetricalglaucomaseverityindifferentglaucomasubtypes AT pererasa intereyecomparisonofretinaloximetryandvesselcaliberbetweeneyeswithasymmetricalglaucomaseverityindifferentglaucomasubtypes
_version_	1718403675842412544

Inter-eye comparison of retinal oximetry and vessel caliber between eyes with asymmetrical glaucoma severity in different glaucoma subtypes

Ejemplares similares