Straight from the Horse’s “Mouth”: Genomic Epidemiology of an Icelandic Equine Epidemic

ABSTRACT Despite tight biosecurity measures, an outbreak of respiratory disease rapidly spread across the Icelandic equine population in 2010. Horse transportation was brought to a halt in order to contain the spread of the infectious agent. In a recent article, Björnsdóttir and colleagues (S. Björn...

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Autor principal:	Mark R. Davies
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2017
Materias:	Streptococcus equi subsp. zooepidemicus equine genome analysis genomic epidemiology outbreak respiratory pathogens Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/57fca62a5e8e4833a548379fb863575f
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spelling	oai:doaj.org-article:57fca62a5e8e4833a548379fb863575f2021-11-15T15:51:52ZStraight from the Horse’s “Mouth”: Genomic Epidemiology of an Icelandic Equine Epidemic10.1128/mBio.01613-172150-7511https://doaj.org/article/57fca62a5e8e4833a548379fb863575f2017-11-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01613-17https://doaj.org/toc/2150-7511ABSTRACT Despite tight biosecurity measures, an outbreak of respiratory disease rapidly spread across the Icelandic equine population in 2010. Horse transportation was brought to a halt in order to contain the spread of the infectious agent. In a recent article, Björnsdóttir and colleagues (S. Björnsdóttir et al., mBio 8:e00826-17, 2017, https://doi.org/10.1128/mBio.00826-17 ) employ the power and resolution of “genomic epidemiology,” the combination of whole genomic sequencing and epidemiological approaches, to examine the source and spread of the outbreak. Intriguingly, the outbreak was not viral in origin, but linked to a bacterial “commensal” Streptococcus equi subsp. zooepidemicus infection. A national sampling strategy coupled with population genomics revealed that the outbreak was most likely driven by a S. equi subsp. zooepidemicus sequence type 209 (ST209) infection that spread nationally from a single source. This retrospective study demonstrates the power of genomics applied on a national scale to unravel the cause of a significant biosecurity threat.Mark R. DaviesAmerican Society for MicrobiologyarticleStreptococcus equi subsp. zooepidemicusequinegenome analysisgenomic epidemiologyoutbreakrespiratory pathogensMicrobiologyQR1-502ENmBio, Vol 8, Iss 5 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Streptococcus equi subsp. zooepidemicus equine genome analysis genomic epidemiology outbreak respiratory pathogens Microbiology QR1-502
spellingShingle	Streptococcus equi subsp. zooepidemicus equine genome analysis genomic epidemiology outbreak respiratory pathogens Microbiology QR1-502 Mark R. Davies Straight from the Horse’s “Mouth”: Genomic Epidemiology of an Icelandic Equine Epidemic
description	ABSTRACT Despite tight biosecurity measures, an outbreak of respiratory disease rapidly spread across the Icelandic equine population in 2010. Horse transportation was brought to a halt in order to contain the spread of the infectious agent. In a recent article, Björnsdóttir and colleagues (S. Björnsdóttir et al., mBio 8:e00826-17, 2017, https://doi.org/10.1128/mBio.00826-17 ) employ the power and resolution of “genomic epidemiology,” the combination of whole genomic sequencing and epidemiological approaches, to examine the source and spread of the outbreak. Intriguingly, the outbreak was not viral in origin, but linked to a bacterial “commensal” Streptococcus equi subsp. zooepidemicus infection. A national sampling strategy coupled with population genomics revealed that the outbreak was most likely driven by a S. equi subsp. zooepidemicus sequence type 209 (ST209) infection that spread nationally from a single source. This retrospective study demonstrates the power of genomics applied on a national scale to unravel the cause of a significant biosecurity threat.
format	article
author	Mark R. Davies
author_facet	Mark R. Davies
author_sort	Mark R. Davies
title	Straight from the Horse’s “Mouth”: Genomic Epidemiology of an Icelandic Equine Epidemic
title_short	Straight from the Horse’s “Mouth”: Genomic Epidemiology of an Icelandic Equine Epidemic
title_full	Straight from the Horse’s “Mouth”: Genomic Epidemiology of an Icelandic Equine Epidemic
title_fullStr	Straight from the Horse’s “Mouth”: Genomic Epidemiology of an Icelandic Equine Epidemic
title_full_unstemmed	Straight from the Horse’s “Mouth”: Genomic Epidemiology of an Icelandic Equine Epidemic
title_sort	straight from the horse’s “mouth”: genomic epidemiology of an icelandic equine epidemic
publisher	American Society for Microbiology
publishDate	2017
url	https://doaj.org/article/57fca62a5e8e4833a548379fb863575f
work_keys_str_mv	AT markrdavies straightfromthehorsesmouthgenomicepidemiologyofanicelandicequineepidemic
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Straight from the Horse’s “Mouth”: Genomic Epidemiology of an Icelandic Equine Epidemic

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