Measuring myocardial extracellular volume of the right ventricle in patients with congenital heart disease

Abstract The right ventricle´s (RV) characteristics—thin walls and trabeculation—make it challenging to evaluate extracellular volume (ECV). We aimed to assess the feasibility of RV ECV measurements in congenital heart disease (CHD), and to introduce a novel ECV analysis tool. Patients (n = 39) and...

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Autores principales:	Nadya Al-Wakeel-Marquard, Tiago Ferreira da Silva, Sarah Jeuthe, Sanaz Rastin, Frédéric Muench, Darach O h-Ici, Sevim Yilmaz, Felix Berger, Titus Kuehne, Daniel R. Messroghli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/57fdad038b6f482f87d1654a20fefc9e
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spelling	oai:doaj.org-article:57fdad038b6f482f87d1654a20fefc9e2021-12-02T13:57:37ZMeasuring myocardial extracellular volume of the right ventricle in patients with congenital heart disease10.1038/s41598-021-81440-z2045-2322https://doaj.org/article/57fdad038b6f482f87d1654a20fefc9e2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81440-zhttps://doaj.org/toc/2045-2322Abstract The right ventricle´s (RV) characteristics—thin walls and trabeculation—make it challenging to evaluate extracellular volume (ECV). We aimed to assess the feasibility of RV ECV measurements in congenital heart disease (CHD), and to introduce a novel ECV analysis tool. Patients (n = 39) and healthy controls (n = 17) underwent cardiovascular magnetic resonance T1 mapping in midventricular short axis (SAX) and transverse orientation (TRANS). Regions of interest (ROIs) were evaluated with regard to image quality and maximum RV wall thickness per ROI in pixels. ECV from plane ROIs was compared with values obtained with a custom-made tool that derives the mean T1 values from a “line of interest” (LOI) centered in the RV wall. In CHD, average image quality was good (no artifacts in the RV, good contrast between blood/myocardium), and RV wall thickness was 1–2 pixels. RV ECV was not quantifiable in 4/39 patients due to insufficient contrast or wall thickness < 1 pixel. RV myocardium tended to be more clearly delineated in SAX than TRANS. ECV from ROIs and corresponding LOIs correlated strongly in both directions (SAX/TRANS: r = 0.97/0.87, p < 0.001, respectively). In conclusion, RV ECV can be assessed if image quality allows sufficient distinction between myocardium and blood, and RV wall thickness per ROI is ≥ 1 pixel. T1 maps in SAX are recommended for RV ECV analysis. LOI application simplifies RV ECV measurements.Nadya Al-Wakeel-MarquardTiago Ferreira da SilvaSarah JeutheSanaz RastinFrédéric MuenchDarach O h-IciSevim YilmazFelix BergerTitus KuehneDaniel R. MessroghliNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nadya Al-Wakeel-Marquard Tiago Ferreira da Silva Sarah Jeuthe Sanaz Rastin Frédéric Muench Darach O h-Ici Sevim Yilmaz Felix Berger Titus Kuehne Daniel R. Messroghli Measuring myocardial extracellular volume of the right ventricle in patients with congenital heart disease
description	Abstract The right ventricle´s (RV) characteristics—thin walls and trabeculation—make it challenging to evaluate extracellular volume (ECV). We aimed to assess the feasibility of RV ECV measurements in congenital heart disease (CHD), and to introduce a novel ECV analysis tool. Patients (n = 39) and healthy controls (n = 17) underwent cardiovascular magnetic resonance T1 mapping in midventricular short axis (SAX) and transverse orientation (TRANS). Regions of interest (ROIs) were evaluated with regard to image quality and maximum RV wall thickness per ROI in pixels. ECV from plane ROIs was compared with values obtained with a custom-made tool that derives the mean T1 values from a “line of interest” (LOI) centered in the RV wall. In CHD, average image quality was good (no artifacts in the RV, good contrast between blood/myocardium), and RV wall thickness was 1–2 pixels. RV ECV was not quantifiable in 4/39 patients due to insufficient contrast or wall thickness < 1 pixel. RV myocardium tended to be more clearly delineated in SAX than TRANS. ECV from ROIs and corresponding LOIs correlated strongly in both directions (SAX/TRANS: r = 0.97/0.87, p < 0.001, respectively). In conclusion, RV ECV can be assessed if image quality allows sufficient distinction between myocardium and blood, and RV wall thickness per ROI is ≥ 1 pixel. T1 maps in SAX are recommended for RV ECV analysis. LOI application simplifies RV ECV measurements.
format	article
author	Nadya Al-Wakeel-Marquard Tiago Ferreira da Silva Sarah Jeuthe Sanaz Rastin Frédéric Muench Darach O h-Ici Sevim Yilmaz Felix Berger Titus Kuehne Daniel R. Messroghli
author_facet	Nadya Al-Wakeel-Marquard Tiago Ferreira da Silva Sarah Jeuthe Sanaz Rastin Frédéric Muench Darach O h-Ici Sevim Yilmaz Felix Berger Titus Kuehne Daniel R. Messroghli
author_sort	Nadya Al-Wakeel-Marquard
title	Measuring myocardial extracellular volume of the right ventricle in patients with congenital heart disease
title_short	Measuring myocardial extracellular volume of the right ventricle in patients with congenital heart disease
title_full	Measuring myocardial extracellular volume of the right ventricle in patients with congenital heart disease
title_fullStr	Measuring myocardial extracellular volume of the right ventricle in patients with congenital heart disease
title_full_unstemmed	Measuring myocardial extracellular volume of the right ventricle in patients with congenital heart disease
title_sort	measuring myocardial extracellular volume of the right ventricle in patients with congenital heart disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/57fdad038b6f482f87d1654a20fefc9e
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Measuring myocardial extracellular volume of the right ventricle in patients with congenital heart disease

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