eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma
Metabolic reprogramming is a hallmark of pancreatic ductal adenocarcinoma (PDA). Here, the authors show that in PDA cells redox and central carbon metabolism are driven by an eIF4F dependent translation program, and combined targeting of eIF4A and glutaminase can impact PDA proliferation.
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Nature Portfolio
2019
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oai:doaj.org-article:5805d19b9df44bceaf4b4ac6e534ad642021-12-02T15:36:06ZeIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma10.1038/s41467-019-13086-52041-1723https://doaj.org/article/5805d19b9df44bceaf4b4ac6e534ad642019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13086-5https://doaj.org/toc/2041-1723Metabolic reprogramming is a hallmark of pancreatic ductal adenocarcinoma (PDA). Here, the authors show that in PDA cells redox and central carbon metabolism are driven by an eIF4F dependent translation program, and combined targeting of eIF4A and glutaminase can impact PDA proliferation.Karina ChanFrancis RobertChristian OertlinDana Kapeller-LibermannDaina AvizonisJohana GutierrezAbram Handly-SantanaMikhail DoubrovinJulia ParkChristina SchoepferBrandon Da SilvaMelissa YaoFaith GortonJunwei ShiCraig J. ThomasLauren E. BrownJohn A. PorcoMichael PollakOla LarssonJerry PelletierIok In Christine ChioNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Karina Chan Francis Robert Christian Oertlin Dana Kapeller-Libermann Daina Avizonis Johana Gutierrez Abram Handly-Santana Mikhail Doubrovin Julia Park Christina Schoepfer Brandon Da Silva Melissa Yao Faith Gorton Junwei Shi Craig J. Thomas Lauren E. Brown John A. Porco Michael Pollak Ola Larsson Jerry Pelletier Iok In Christine Chio eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma |
| description |
Metabolic reprogramming is a hallmark of pancreatic ductal adenocarcinoma (PDA). Here, the authors show that in PDA cells redox and central carbon metabolism are driven by an eIF4F dependent translation program, and combined targeting of eIF4A and glutaminase can impact PDA proliferation. |
| format |
article |
| author |
Karina Chan Francis Robert Christian Oertlin Dana Kapeller-Libermann Daina Avizonis Johana Gutierrez Abram Handly-Santana Mikhail Doubrovin Julia Park Christina Schoepfer Brandon Da Silva Melissa Yao Faith Gorton Junwei Shi Craig J. Thomas Lauren E. Brown John A. Porco Michael Pollak Ola Larsson Jerry Pelletier Iok In Christine Chio |
| author_facet |
Karina Chan Francis Robert Christian Oertlin Dana Kapeller-Libermann Daina Avizonis Johana Gutierrez Abram Handly-Santana Mikhail Doubrovin Julia Park Christina Schoepfer Brandon Da Silva Melissa Yao Faith Gorton Junwei Shi Craig J. Thomas Lauren E. Brown John A. Porco Michael Pollak Ola Larsson Jerry Pelletier Iok In Christine Chio |
| author_sort |
Karina Chan |
| title |
eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma |
| title_short |
eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma |
| title_full |
eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma |
| title_fullStr |
eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma |
| title_full_unstemmed |
eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma |
| title_sort |
eif4a supports an oncogenic translation program in pancreatic ductal adenocarcinoma |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/5805d19b9df44bceaf4b4ac6e534ad64 |
| work_keys_str_mv |
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| _version_ |
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