ALGORITHM OF LABORATORY CONFIRMATION AND DIFFERENTIAL DIAGNOSIS OF MEASLES INFECTION AT THE STAGE OF THE MEASLES ELIMINATION PROGRAM IN RUSSIA

The modified algorithm for laboratory confirmation and differential diagnosis of measles infection was developed and used in the laboratory studies of the Russian Laboratory Network (RLN) on Measles/Rubella Surveillance within the routine and active measles infection control. The algorithm consists...

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Autores principales:	Т. А. Mamaeva, N. V. Zheleznova, М. А. Nаumova, M. V. Govoruhina, N. A. Kalashnikova, M. A. Bichurina, S. L. Mukomolov
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2015
Materias:	measles elisa the primary immune response the secondary immune response avidity igg antibodies Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/5809ad9cdb13420e8ee41bbcef5c2c82
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spelling	oai:doaj.org-article:5809ad9cdb13420e8ee41bbcef5c2c822021-11-22T07:09:47ZALGORITHM OF LABORATORY CONFIRMATION AND DIFFERENTIAL DIAGNOSIS OF MEASLES INFECTION AT THE STAGE OF THE MEASLES ELIMINATION PROGRAM IN RUSSIA2220-76192313-739810.15789/2220-7619-2015-1-55-62https://doaj.org/article/5809ad9cdb13420e8ee41bbcef5c2c822015-04-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/274https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398The modified algorithm for laboratory confirmation and differential diagnosis of measles infection was developed and used in the laboratory studies of the Russian Laboratory Network (RLN) on Measles/Rubella Surveillance within the routine and active measles infection control. The algorithm consists in detecting the IgM, IgG and IgG avidity measles virus antibodies. To approve the modified algorithm sera samples of 637 patients with the measles diagnosis and 423 patients with rush and fever were studied. The IgG avidity measles testing is advisable in the following cases: a) only one serum sample is available, b) the recommended time interval between the 1st and 2nd sera samples taking is not observed, c) no diagnostic increase in titers of the IgG measles virus antibodies is evidenced, d) for determination of the type of immune response (primary or secondary) and e) to exclude the “false positive” results at the stage of detecting the measles virus IgM antibodies. Moreover the data obtained evidenced the involvement of the nonvaccinated (79.7%) as well as of vaccinated with 1 or 2 doses of measles vaccine (20.3%) population into the measles epidemical process.Т. А. MamaevaN. V. ZheleznovaМ. А. NаumovaM. V. GovoruhinaN. A. KalashnikovaM. A. BichurinaS. L. MukomolovSankt-Peterburg : NIIÈM imeni Pasteraarticlemeasleselisathe primary immune responsethe secondary immune responseavidity igg antibodiesInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 5, Iss 1, Pp 55-62 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	measles elisa the primary immune response the secondary immune response avidity igg antibodies Infectious and parasitic diseases RC109-216
spellingShingle	measles elisa the primary immune response the secondary immune response avidity igg antibodies Infectious and parasitic diseases RC109-216 Т. А. Mamaeva N. V. Zheleznova М. А. Nаumova M. V. Govoruhina N. A. Kalashnikova M. A. Bichurina S. L. Mukomolov ALGORITHM OF LABORATORY CONFIRMATION AND DIFFERENTIAL DIAGNOSIS OF MEASLES INFECTION AT THE STAGE OF THE MEASLES ELIMINATION PROGRAM IN RUSSIA
description	The modified algorithm for laboratory confirmation and differential diagnosis of measles infection was developed and used in the laboratory studies of the Russian Laboratory Network (RLN) on Measles/Rubella Surveillance within the routine and active measles infection control. The algorithm consists in detecting the IgM, IgG and IgG avidity measles virus antibodies. To approve the modified algorithm sera samples of 637 patients with the measles diagnosis and 423 patients with rush and fever were studied. The IgG avidity measles testing is advisable in the following cases: a) only one serum sample is available, b) the recommended time interval between the 1st and 2nd sera samples taking is not observed, c) no diagnostic increase in titers of the IgG measles virus antibodies is evidenced, d) for determination of the type of immune response (primary or secondary) and e) to exclude the “false positive” results at the stage of detecting the measles virus IgM antibodies. Moreover the data obtained evidenced the involvement of the nonvaccinated (79.7%) as well as of vaccinated with 1 or 2 doses of measles vaccine (20.3%) population into the measles epidemical process.
format	article
author	Т. А. Mamaeva N. V. Zheleznova М. А. Nаumova M. V. Govoruhina N. A. Kalashnikova M. A. Bichurina S. L. Mukomolov
author_facet	Т. А. Mamaeva N. V. Zheleznova М. А. Nаumova M. V. Govoruhina N. A. Kalashnikova M. A. Bichurina S. L. Mukomolov
author_sort	Т. А. Mamaeva
title	ALGORITHM OF LABORATORY CONFIRMATION AND DIFFERENTIAL DIAGNOSIS OF MEASLES INFECTION AT THE STAGE OF THE MEASLES ELIMINATION PROGRAM IN RUSSIA
title_short	ALGORITHM OF LABORATORY CONFIRMATION AND DIFFERENTIAL DIAGNOSIS OF MEASLES INFECTION AT THE STAGE OF THE MEASLES ELIMINATION PROGRAM IN RUSSIA
title_full	ALGORITHM OF LABORATORY CONFIRMATION AND DIFFERENTIAL DIAGNOSIS OF MEASLES INFECTION AT THE STAGE OF THE MEASLES ELIMINATION PROGRAM IN RUSSIA
title_fullStr	ALGORITHM OF LABORATORY CONFIRMATION AND DIFFERENTIAL DIAGNOSIS OF MEASLES INFECTION AT THE STAGE OF THE MEASLES ELIMINATION PROGRAM IN RUSSIA
title_full_unstemmed	ALGORITHM OF LABORATORY CONFIRMATION AND DIFFERENTIAL DIAGNOSIS OF MEASLES INFECTION AT THE STAGE OF THE MEASLES ELIMINATION PROGRAM IN RUSSIA
title_sort	algorithm of laboratory confirmation and differential diagnosis of measles infection at the stage of the measles elimination program in russia
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2015
url	https://doaj.org/article/5809ad9cdb13420e8ee41bbcef5c2c82
work_keys_str_mv	AT tamamaeva algorithmoflaboratoryconfirmationanddifferentialdiagnosisofmeaslesinfectionatthestageofthemeasleseliminationprograminrussia AT nvzheleznova algorithmoflaboratoryconfirmationanddifferentialdiagnosisofmeaslesinfectionatthestageofthemeasleseliminationprograminrussia AT manaumova algorithmoflaboratoryconfirmationanddifferentialdiagnosisofmeaslesinfectionatthestageofthemeasleseliminationprograminrussia AT mvgovoruhina algorithmoflaboratoryconfirmationanddifferentialdiagnosisofmeaslesinfectionatthestageofthemeasleseliminationprograminrussia AT nakalashnikova algorithmoflaboratoryconfirmationanddifferentialdiagnosisofmeaslesinfectionatthestageofthemeasleseliminationprograminrussia AT mabichurina algorithmoflaboratoryconfirmationanddifferentialdiagnosisofmeaslesinfectionatthestageofthemeasleseliminationprograminrussia AT slmukomolov algorithmoflaboratoryconfirmationanddifferentialdiagnosisofmeaslesinfectionatthestageofthemeasleseliminationprograminrussia
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ALGORITHM OF LABORATORY CONFIRMATION AND DIFFERENTIAL DIAGNOSIS OF MEASLES INFECTION AT THE STAGE OF THE MEASLES ELIMINATION PROGRAM IN RUSSIA

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