LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores
During cell division, faithful chromosome segregation requires proper chromosome congression and dynamic maintenance of the aligned chromosomes. Here, the authors find that LUBAC promotes dynamic chromosome congression and alignment by targeting kinetochore motor CENP-E to the KMN network.
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Nature Portfolio
2019
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oai:doaj.org-article:5809cafc35ca4635be9bb6eaa78f6d832021-12-02T17:02:14ZLUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores10.1038/s41467-018-08043-72041-1723https://doaj.org/article/5809cafc35ca4635be9bb6eaa78f6d832019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08043-7https://doaj.org/toc/2041-1723During cell division, faithful chromosome segregation requires proper chromosome congression and dynamic maintenance of the aligned chromosomes. Here, the authors find that LUBAC promotes dynamic chromosome congression and alignment by targeting kinetochore motor CENP-E to the KMN network.Min WuYan ChangHuaibin HuRui MuYucheng ZhangXuanhe QinXiaotao DuanWeihua LiHaiqing TuWeina ZhangGuang WangQiuying HanAiling LiTao ZhouKazuhiro IwaiXuemin ZhangHuiyan LiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
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DOAJ |
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DOAJ |
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EN |
topic |
Science Q |
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Science Q Min Wu Yan Chang Huaibin Hu Rui Mu Yucheng Zhang Xuanhe Qin Xiaotao Duan Weihua Li Haiqing Tu Weina Zhang Guang Wang Qiuying Han Ailing Li Tao Zhou Kazuhiro Iwai Xuemin Zhang Huiyan Li LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores |
description |
During cell division, faithful chromosome segregation requires proper chromosome congression and dynamic maintenance of the aligned chromosomes. Here, the authors find that LUBAC promotes dynamic chromosome congression and alignment by targeting kinetochore motor CENP-E to the KMN network. |
format |
article |
author |
Min Wu Yan Chang Huaibin Hu Rui Mu Yucheng Zhang Xuanhe Qin Xiaotao Duan Weihua Li Haiqing Tu Weina Zhang Guang Wang Qiuying Han Ailing Li Tao Zhou Kazuhiro Iwai Xuemin Zhang Huiyan Li |
author_facet |
Min Wu Yan Chang Huaibin Hu Rui Mu Yucheng Zhang Xuanhe Qin Xiaotao Duan Weihua Li Haiqing Tu Weina Zhang Guang Wang Qiuying Han Ailing Li Tao Zhou Kazuhiro Iwai Xuemin Zhang Huiyan Li |
author_sort |
Min Wu |
title |
LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores |
title_short |
LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores |
title_full |
LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores |
title_fullStr |
LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores |
title_full_unstemmed |
LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores |
title_sort |
lubac controls chromosome alignment by targeting cenp-e to attached kinetochores |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/5809cafc35ca4635be9bb6eaa78f6d83 |
work_keys_str_mv |
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