LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores

During cell division, faithful chromosome segregation requires proper chromosome congression and dynamic maintenance of the aligned chromosomes. Here, the authors find that LUBAC promotes dynamic chromosome congression and alignment by targeting kinetochore motor CENP-E to the KMN network.

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Autores principales: Min Wu, Yan Chang, Huaibin Hu, Rui Mu, Yucheng Zhang, Xuanhe Qin, Xiaotao Duan, Weihua Li, Haiqing Tu, Weina Zhang, Guang Wang, Qiuying Han, Ailing Li, Tao Zhou, Kazuhiro Iwai, Xuemin Zhang, Huiyan Li
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/5809cafc35ca4635be9bb6eaa78f6d83
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spelling oai:doaj.org-article:5809cafc35ca4635be9bb6eaa78f6d832021-12-02T17:02:14ZLUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores10.1038/s41467-018-08043-72041-1723https://doaj.org/article/5809cafc35ca4635be9bb6eaa78f6d832019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08043-7https://doaj.org/toc/2041-1723During cell division, faithful chromosome segregation requires proper chromosome congression and dynamic maintenance of the aligned chromosomes. Here, the authors find that LUBAC promotes dynamic chromosome congression and alignment by targeting kinetochore motor CENP-E to the KMN network.Min WuYan ChangHuaibin HuRui MuYucheng ZhangXuanhe QinXiaotao DuanWeihua LiHaiqing TuWeina ZhangGuang WangQiuying HanAiling LiTao ZhouKazuhiro IwaiXuemin ZhangHuiyan LiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Min Wu
Yan Chang
Huaibin Hu
Rui Mu
Yucheng Zhang
Xuanhe Qin
Xiaotao Duan
Weihua Li
Haiqing Tu
Weina Zhang
Guang Wang
Qiuying Han
Ailing Li
Tao Zhou
Kazuhiro Iwai
Xuemin Zhang
Huiyan Li
LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores
description During cell division, faithful chromosome segregation requires proper chromosome congression and dynamic maintenance of the aligned chromosomes. Here, the authors find that LUBAC promotes dynamic chromosome congression and alignment by targeting kinetochore motor CENP-E to the KMN network.
format article
author Min Wu
Yan Chang
Huaibin Hu
Rui Mu
Yucheng Zhang
Xuanhe Qin
Xiaotao Duan
Weihua Li
Haiqing Tu
Weina Zhang
Guang Wang
Qiuying Han
Ailing Li
Tao Zhou
Kazuhiro Iwai
Xuemin Zhang
Huiyan Li
author_facet Min Wu
Yan Chang
Huaibin Hu
Rui Mu
Yucheng Zhang
Xuanhe Qin
Xiaotao Duan
Weihua Li
Haiqing Tu
Weina Zhang
Guang Wang
Qiuying Han
Ailing Li
Tao Zhou
Kazuhiro Iwai
Xuemin Zhang
Huiyan Li
author_sort Min Wu
title LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores
title_short LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores
title_full LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores
title_fullStr LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores
title_full_unstemmed LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores
title_sort lubac controls chromosome alignment by targeting cenp-e to attached kinetochores
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/5809cafc35ca4635be9bb6eaa78f6d83
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