Single-cell lipidomics with high structural specificity by mass spectrometry

Analyzing the lipidomes of single cells remains a challenge. Here, the authors present a strategy to identify class, fatty acyl-chain, C=C locations and sn-positions of lipids in single cells, and use their method to identify individual gefitinib-resistant cells in a wild-type lung cancer cell popul...

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Autores principales:	Zishuai Li, Simin Cheng, Qiaohong Lin, Wenbo Cao, Jing Yang, Minmin Zhang, Aijun Shen, Wenpeng Zhang, Yu Xia, Xiaoxiao Ma, Zheng Ouyang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/580b859bf86d4842856d2728c7891b2d
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spelling	oai:doaj.org-article:580b859bf86d4842856d2728c7891b2d2021-12-02T14:58:43ZSingle-cell lipidomics with high structural specificity by mass spectrometry10.1038/s41467-021-23161-52041-1723https://doaj.org/article/580b859bf86d4842856d2728c7891b2d2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23161-5https://doaj.org/toc/2041-1723Analyzing the lipidomes of single cells remains a challenge. Here, the authors present a strategy to identify class, fatty acyl-chain, C=C locations and sn-positions of lipids in single cells, and use their method to identify individual gefitinib-resistant cells in a wild-type lung cancer cell population.Zishuai LiSimin ChengQiaohong LinWenbo CaoJing YangMinmin ZhangAijun ShenWenpeng ZhangYu XiaXiaoxiao MaZheng OuyangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zishuai Li Simin Cheng Qiaohong Lin Wenbo Cao Jing Yang Minmin Zhang Aijun Shen Wenpeng Zhang Yu Xia Xiaoxiao Ma Zheng Ouyang Single-cell lipidomics with high structural specificity by mass spectrometry
description	Analyzing the lipidomes of single cells remains a challenge. Here, the authors present a strategy to identify class, fatty acyl-chain, C=C locations and sn-positions of lipids in single cells, and use their method to identify individual gefitinib-resistant cells in a wild-type lung cancer cell population.
format	article
author	Zishuai Li Simin Cheng Qiaohong Lin Wenbo Cao Jing Yang Minmin Zhang Aijun Shen Wenpeng Zhang Yu Xia Xiaoxiao Ma Zheng Ouyang
author_facet	Zishuai Li Simin Cheng Qiaohong Lin Wenbo Cao Jing Yang Minmin Zhang Aijun Shen Wenpeng Zhang Yu Xia Xiaoxiao Ma Zheng Ouyang
author_sort	Zishuai Li
title	Single-cell lipidomics with high structural specificity by mass spectrometry
title_short	Single-cell lipidomics with high structural specificity by mass spectrometry
title_full	Single-cell lipidomics with high structural specificity by mass spectrometry
title_fullStr	Single-cell lipidomics with high structural specificity by mass spectrometry
title_full_unstemmed	Single-cell lipidomics with high structural specificity by mass spectrometry
title_sort	single-cell lipidomics with high structural specificity by mass spectrometry
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/580b859bf86d4842856d2728c7891b2d
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Single-cell lipidomics with high structural specificity by mass spectrometry

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