EFFICACY OF GENERIC DRUG WARTOCID® (IMIQUIMOD 5% CREAM FOR EXTERNAL USE) IN ANOGENITAL WARTS TREATMENT

Aim. To evaluate the efficacy and safety of the generic drug Wartocid® (Imiquimod cream 5% for external use) in patients with external anogenital (venereal) warts (AGW). Materials and methods. The single-blind comparative, randomized, placebo-controlled clinical trial included 50 women aged 18 to 60...

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Autores principales:	V. S. Smirnova, S. V. Petlenkoa, S. A. Savelyeva, G. Redlichb, N. I. Stukana
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2017
Materias:	imiquimod wartocid clinical trial efficacy safety external anogenital (venereal) warts Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/580c8dee77b249159e713b4314875a6b
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spelling	oai:doaj.org-article:580c8dee77b249159e713b4314875a6b2021-11-22T07:09:48ZEFFICACY OF GENERIC DRUG WARTOCID® (IMIQUIMOD 5% CREAM FOR EXTERNAL USE) IN ANOGENITAL WARTS TREATMENT2220-76192313-739810.15789/2220-7619-2017-3-279-284https://doaj.org/article/580c8dee77b249159e713b4314875a6b2017-09-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/560https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Aim. To evaluate the efficacy and safety of the generic drug Wartocid® (Imiquimod cream 5% for external use) in patients with external anogenital (venereal) warts (AGW). Materials and methods. The single-blind comparative, randomized, placebo-controlled clinical trial included 50 women aged 18 to 60 with an established clinical diagnosis of AGW in the vulva and perianal region. Patients in group 1 received placebo cream for external use, while patients in group 2 received therapy with Wartoсid in a daily dose of 10 mg cream/cm2 of skin area. The drug was applied every other day until the complete disappearance of AGW, but in any case, not more than 16 weeks. A follow-up was carried out for 4 more weeks. The study evaluated the dynamics of subjective and objective symptoms, the presence and the frequency of relapses, and the percentage of full treatment of AGW.Main results. Treatment with Wartoсid resulted in a complete cure of AGW in 16% of patients, and a reduction in the focus area of AGW in 36% of patients. Against the background of the placebo no dynamics of the disease were reached. Neither serious adverse events nor clinically significant changes in blood tests, urine or serum biochemical parameters in any of the patients who received treatment with Wartoсid were observed. Conclusion. The generic drug Wartocid has been proved to be effective and safe for AGW treatment and its effectiveness is similar to the original drug Aldara® (Imiquimod cream 5% for external use).V. S. SmirnovaS. V. PetlenkoaS. A. SavelyevaG. RedlichbN. I. StukanaSankt-Peterburg : NIIÈM imeni Pasteraarticleimiquimodwartocidclinical trialefficacysafetyexternal anogenital (venereal) wartsInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 7, Iss 3, Pp 279-284 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	imiquimod wartocid clinical trial efficacy safety external anogenital (venereal) warts Infectious and parasitic diseases RC109-216
spellingShingle	imiquimod wartocid clinical trial efficacy safety external anogenital (venereal) warts Infectious and parasitic diseases RC109-216 V. S. Smirnova S. V. Petlenkoa S. A. Savelyeva G. Redlichb N. I. Stukana EFFICACY OF GENERIC DRUG WARTOCID® (IMIQUIMOD 5% CREAM FOR EXTERNAL USE) IN ANOGENITAL WARTS TREATMENT
description	Aim. To evaluate the efficacy and safety of the generic drug Wartocid® (Imiquimod cream 5% for external use) in patients with external anogenital (venereal) warts (AGW). Materials and methods. The single-blind comparative, randomized, placebo-controlled clinical trial included 50 women aged 18 to 60 with an established clinical diagnosis of AGW in the vulva and perianal region. Patients in group 1 received placebo cream for external use, while patients in group 2 received therapy with Wartoсid in a daily dose of 10 mg cream/cm2 of skin area. The drug was applied every other day until the complete disappearance of AGW, but in any case, not more than 16 weeks. A follow-up was carried out for 4 more weeks. The study evaluated the dynamics of subjective and objective symptoms, the presence and the frequency of relapses, and the percentage of full treatment of AGW.Main results. Treatment with Wartoсid resulted in a complete cure of AGW in 16% of patients, and a reduction in the focus area of AGW in 36% of patients. Against the background of the placebo no dynamics of the disease were reached. Neither serious adverse events nor clinically significant changes in blood tests, urine or serum biochemical parameters in any of the patients who received treatment with Wartoсid were observed. Conclusion. The generic drug Wartocid has been proved to be effective and safe for AGW treatment and its effectiveness is similar to the original drug Aldara® (Imiquimod cream 5% for external use).
format	article
author	V. S. Smirnova S. V. Petlenkoa S. A. Savelyeva G. Redlichb N. I. Stukana
author_facet	V. S. Smirnova S. V. Petlenkoa S. A. Savelyeva G. Redlichb N. I. Stukana
author_sort	V. S. Smirnova
title	EFFICACY OF GENERIC DRUG WARTOCID® (IMIQUIMOD 5% CREAM FOR EXTERNAL USE) IN ANOGENITAL WARTS TREATMENT
title_short	EFFICACY OF GENERIC DRUG WARTOCID® (IMIQUIMOD 5% CREAM FOR EXTERNAL USE) IN ANOGENITAL WARTS TREATMENT
title_full	EFFICACY OF GENERIC DRUG WARTOCID® (IMIQUIMOD 5% CREAM FOR EXTERNAL USE) IN ANOGENITAL WARTS TREATMENT
title_fullStr	EFFICACY OF GENERIC DRUG WARTOCID® (IMIQUIMOD 5% CREAM FOR EXTERNAL USE) IN ANOGENITAL WARTS TREATMENT
title_full_unstemmed	EFFICACY OF GENERIC DRUG WARTOCID® (IMIQUIMOD 5% CREAM FOR EXTERNAL USE) IN ANOGENITAL WARTS TREATMENT
title_sort	efficacy of generic drug wartocid® (imiquimod 5% cream for external use) in anogenital warts treatment
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2017
url	https://doaj.org/article/580c8dee77b249159e713b4314875a6b
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EFFICACY OF GENERIC DRUG WARTOCID® (IMIQUIMOD 5% CREAM FOR EXTERNAL USE) IN ANOGENITAL WARTS TREATMENT

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