Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis

Integrins regulate haematopoietic stem cell (HSC) homeostasis and engraftment into the bone marrow (BM) niche upon transplantation. Here, the authors show that HSC quiescence and function in the BM is regulated by the interaction of PERIOSTIN and INTEGRIN αv and subsequent increase in p27Kip1.

Guardado en:

Detalles Bibliográficos
Autores principales:	Satish Khurana, Sarah Schouteden, Javed K. Manesia, Albert Santamaria-Martínez, Joerg Huelsken, Adam Lacy-Hulbert, Catherine M. Verfaillie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/581340b96b30494088f56d7eb294bd30
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:581340b96b30494088f56d7eb294bd30
record_format	dspace
spelling	oai:doaj.org-article:581340b96b30494088f56d7eb294bd302021-12-02T16:56:47ZOutside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis10.1038/ncomms135002041-1723https://doaj.org/article/581340b96b30494088f56d7eb294bd302016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13500https://doaj.org/toc/2041-1723Integrins regulate haematopoietic stem cell (HSC) homeostasis and engraftment into the bone marrow (BM) niche upon transplantation. Here, the authors show that HSC quiescence and function in the BM is regulated by the interaction of PERIOSTIN and INTEGRIN αv and subsequent increase in p27Kip1.Satish KhuranaSarah SchoutedenJaved K. ManesiaAlbert Santamaria-MartínezJoerg HuelskenAdam Lacy-HulbertCatherine M. VerfaillieNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Satish Khurana Sarah Schouteden Javed K. Manesia Albert Santamaria-Martínez Joerg Huelsken Adam Lacy-Hulbert Catherine M. Verfaillie Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis
description	Integrins regulate haematopoietic stem cell (HSC) homeostasis and engraftment into the bone marrow (BM) niche upon transplantation. Here, the authors show that HSC quiescence and function in the BM is regulated by the interaction of PERIOSTIN and INTEGRIN αv and subsequent increase in p27Kip1.
format	article
author	Satish Khurana Sarah Schouteden Javed K. Manesia Albert Santamaria-Martínez Joerg Huelsken Adam Lacy-Hulbert Catherine M. Verfaillie
author_facet	Satish Khurana Sarah Schouteden Javed K. Manesia Albert Santamaria-Martínez Joerg Huelsken Adam Lacy-Hulbert Catherine M. Verfaillie
author_sort	Satish Khurana
title	Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis
title_short	Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis
title_full	Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis
title_fullStr	Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis
title_full_unstemmed	Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis
title_sort	outside-in integrin signalling regulates haematopoietic stem cell function via periostin-itgav axis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/581340b96b30494088f56d7eb294bd30
work_keys_str_mv	AT satishkhurana outsideinintegrinsignallingregulateshaematopoieticstemcellfunctionviaperiostinitgavaxis AT sarahschouteden outsideinintegrinsignallingregulateshaematopoieticstemcellfunctionviaperiostinitgavaxis AT javedkmanesia outsideinintegrinsignallingregulateshaematopoieticstemcellfunctionviaperiostinitgavaxis AT albertsantamariamartinez outsideinintegrinsignallingregulateshaematopoieticstemcellfunctionviaperiostinitgavaxis AT joerghuelsken outsideinintegrinsignallingregulateshaematopoieticstemcellfunctionviaperiostinitgavaxis AT adamlacyhulbert outsideinintegrinsignallingregulateshaematopoieticstemcellfunctionviaperiostinitgavaxis AT catherinemverfaillie outsideinintegrinsignallingregulateshaematopoieticstemcellfunctionviaperiostinitgavaxis
_version_	1718382739816710144

Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis

Ejemplares similares