Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis

Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis

Integrins regulate haematopoietic stem cell (HSC) homeostasis and engraftment into the bone marrow (BM) niche upon transplantation. Here, the authors show that HSC quiescence and function in the BM is regulated by the interaction of PERIOSTIN and INTEGRIN αv and subsequent increase in p27Kip1.

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Detalles Bibliográficos
Autores principales: Satish Khurana, Sarah Schouteden, Javed K. Manesia, Albert Santamaria-Martínez, Joerg Huelsken, Adam Lacy-Hulbert, Catherine M. Verfaillie
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
Q
Acceso en línea:https://doaj.org/article/581340b96b30494088f56d7eb294bd30
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