The Rostromedial Tegmental Nucleus: Anatomical Studies and Roles in Sleep and Substance Addictions in Rats and Mice
Ya-Nan Zhao,1,* Yu-Dong Yan,1,* Chen-Yao Wang,1 Wei-Min Qu,1 Thomas C Jhou,2 Zhi-Li Huang,1 Su-Rong Yang1 1Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, People’s Republic of China; 2Department of Neuroscience, Medical University of South Carolina...
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Dove Medical Press
2020
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oai:doaj.org-article:5815803c48614b9981c2b066dc5d9d3a2021-12-02T12:01:07ZThe Rostromedial Tegmental Nucleus: Anatomical Studies and Roles in Sleep and Substance Addictions in Rats and Mice1179-1608https://doaj.org/article/5815803c48614b9981c2b066dc5d9d3a2020-12-01T00:00:00Zhttps://www.dovepress.com/the-rostromedial-tegmental-nucleus-anatomical-studies-and-roles-in-sle-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Ya-Nan Zhao,1,* Yu-Dong Yan,1,* Chen-Yao Wang,1 Wei-Min Qu,1 Thomas C Jhou,2 Zhi-Li Huang,1 Su-Rong Yang1 1Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, People’s Republic of China; 2Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA*These authors contributed equally to this workCorrespondence: Su-Rong Yang; Zhi-Li HuangDepartment of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, People’s Republic of ChinaTel/Fax +86-21-54237228; +86-21-54237103Email sryang@shmu.edu.cn; huangzl@fudan.edu.cnAbstract: The rostromedial tegmental nucleus (RMTg), a brake of the dopamine system, is specifically activated by aversive stimuli, such as foot shock. It is principally composed of gamma-aminobutyric acid neurons. However, there is no exact location of the RMTg on the brain stereotaxic atlas. The RMTg can be defined by c-Fos staining elicited by psychostimulants, the position of retrograde-labeled neurons stained by injections into the ventral tegmental area (VTA), the terminal field formed by axons from the lateral habenula, and some molecular markers identified as specifically expressed in the RMTg such as FoxP1. The RMTg receives a broad range of inputs and produces diverse outputs, which indicates that the RMTg has multiple functions. First, the RMTg plays an essential role for non-rapid eye movement sleep. Additionally, the RMTg serves a vital role in response to addiction. Opiates increase the firing rates of dopaminergic neurons in the VTA by acting on μ-opioid receptors on RMTg neurons and their terminals inside the VTA. In this review, we summarize the recent research advances on the anatomical location of the RMTg in rats and mice, its projections, and its regulation of sleep–wake behavior and addiction.Keywords: rostromedial tegmental nucleus, anatomical location, projections, sleep–wake behavior, addictionZhao YNYan YDWang CYQu WMJhou TCHuang ZLYang SRDove Medical Pressarticlerostromedial tegmental nucleusanatomical locationsleep–wake behaviorprojectionsaddictionPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 12, Pp 1215-1223 (2020) |
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rostromedial tegmental nucleus anatomical location sleep–wake behavior projections addiction Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 |
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rostromedial tegmental nucleus anatomical location sleep–wake behavior projections addiction Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Zhao YN Yan YD Wang CY Qu WM Jhou TC Huang ZL Yang SR The Rostromedial Tegmental Nucleus: Anatomical Studies and Roles in Sleep and Substance Addictions in Rats and Mice |
| description |
Ya-Nan Zhao,1,* Yu-Dong Yan,1,* Chen-Yao Wang,1 Wei-Min Qu,1 Thomas C Jhou,2 Zhi-Li Huang,1 Su-Rong Yang1 1Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, People’s Republic of China; 2Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA*These authors contributed equally to this workCorrespondence: Su-Rong Yang; Zhi-Li HuangDepartment of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, People’s Republic of ChinaTel/Fax +86-21-54237228; +86-21-54237103Email sryang@shmu.edu.cn; huangzl@fudan.edu.cnAbstract: The rostromedial tegmental nucleus (RMTg), a brake of the dopamine system, is specifically activated by aversive stimuli, such as foot shock. It is principally composed of gamma-aminobutyric acid neurons. However, there is no exact location of the RMTg on the brain stereotaxic atlas. The RMTg can be defined by c-Fos staining elicited by psychostimulants, the position of retrograde-labeled neurons stained by injections into the ventral tegmental area (VTA), the terminal field formed by axons from the lateral habenula, and some molecular markers identified as specifically expressed in the RMTg such as FoxP1. The RMTg receives a broad range of inputs and produces diverse outputs, which indicates that the RMTg has multiple functions. First, the RMTg plays an essential role for non-rapid eye movement sleep. Additionally, the RMTg serves a vital role in response to addiction. Opiates increase the firing rates of dopaminergic neurons in the VTA by acting on μ-opioid receptors on RMTg neurons and their terminals inside the VTA. In this review, we summarize the recent research advances on the anatomical location of the RMTg in rats and mice, its projections, and its regulation of sleep–wake behavior and addiction.Keywords: rostromedial tegmental nucleus, anatomical location, projections, sleep–wake behavior, addiction |
| format |
article |
| author |
Zhao YN Yan YD Wang CY Qu WM Jhou TC Huang ZL Yang SR |
| author_facet |
Zhao YN Yan YD Wang CY Qu WM Jhou TC Huang ZL Yang SR |
| author_sort |
Zhao YN |
| title |
The Rostromedial Tegmental Nucleus: Anatomical Studies and Roles in Sleep and Substance Addictions in Rats and Mice |
| title_short |
The Rostromedial Tegmental Nucleus: Anatomical Studies and Roles in Sleep and Substance Addictions in Rats and Mice |
| title_full |
The Rostromedial Tegmental Nucleus: Anatomical Studies and Roles in Sleep and Substance Addictions in Rats and Mice |
| title_fullStr |
The Rostromedial Tegmental Nucleus: Anatomical Studies and Roles in Sleep and Substance Addictions in Rats and Mice |
| title_full_unstemmed |
The Rostromedial Tegmental Nucleus: Anatomical Studies and Roles in Sleep and Substance Addictions in Rats and Mice |
| title_sort |
rostromedial tegmental nucleus: anatomical studies and roles in sleep and substance addictions in rats and mice |
| publisher |
Dove Medical Press |
| publishDate |
2020 |
| url |
https://doaj.org/article/5815803c48614b9981c2b066dc5d9d3a |
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