Spectral-domain optical coherence tomographic and fundus autofluorescence findings in eyes with primary intraocular lymphoma

Mariko Egawa, Yoshinori Mitamura, Yuki Hayashi, Takeshi NaitoDepartment of Ophthalmology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, JapanBackground: The purpose of this study was to evaluate the findings on spectral-domain optical coherence tomography...

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Autores principales:	Egawa M, Mitamura Y, Hayashi Y, Naito T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/581733b23ee04606abce493c1f431442
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spelling	oai:doaj.org-article:581733b23ee04606abce493c1f4314422021-12-02T06:19:46ZSpectral-domain optical coherence tomographic and fundus autofluorescence findings in eyes with primary intraocular lymphoma1177-5483https://doaj.org/article/581733b23ee04606abce493c1f4314422014-01-01T00:00:00Zhttp://www.dovepress.com/spectral-domain-optical-coherence-tomographic-and-fundus-autofluoresce-a15687https://doaj.org/toc/1177-5483 Mariko Egawa, Yoshinori Mitamura, Yuki Hayashi, Takeshi NaitoDepartment of Ophthalmology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, JapanBackground: The purpose of this study was to evaluate the findings on spectral-domain optical coherence tomography (SD-OCT) and fundus autofluorescence (FAF) in three eyes with primary intraocular lymphoma (PIOL).Methods: The medical records of three eyes from three patients with biopsy-proven PIOL and retinal infiltrations were reviewed. The SD-OCT and fluorescein angiographic findings were evaluated in the three eyes and FAF images in two eyes.Results: The PIOL in the three patients was monocular. Vitreous opacities and retinal infiltrations were observed in the three eyes, and iritis was present in two eyes. The cytologic diagnosis was class V in two eyes and class III in one eye. The interleukin-10/interleukin-6 ratio was >1.0 in the vitreous and aqueous humor of the three eyes. The FAF images for two eyes showed abnormal granular hyperautofluorescence and hypoautofluorescence which were the reverse of the pattern in the fluorescein angiographic images. In all three eyes, SD-OCT showed hyper-reflective infiltrations at the level of the retinal pigment epithelium (RPE), a separation of the Bruch membrane from the RPE, damage to the RPE, disruption of the photoreceptor inner segment/outer segment junction, and multiple hyper-reflective signals in the inner retina.Conclusion: Because of the characteristic FAF and SD-OCT findings in these eyes with PIOL, we suggest that these noninvasive methods may be used for a rapid diagnosis of PIOL and also for understanding the pathology of PIOL.Keywords: spectral-domain optical coherence tomography, fundus autofluorescence, primary intraocular lymphomaEgawa MMitamura YHayashi YNaito TDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 335-341 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Egawa M Mitamura Y Hayashi Y Naito T Spectral-domain optical coherence tomographic and fundus autofluorescence findings in eyes with primary intraocular lymphoma
description	Mariko Egawa, Yoshinori Mitamura, Yuki Hayashi, Takeshi NaitoDepartment of Ophthalmology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, JapanBackground: The purpose of this study was to evaluate the findings on spectral-domain optical coherence tomography (SD-OCT) and fundus autofluorescence (FAF) in three eyes with primary intraocular lymphoma (PIOL).Methods: The medical records of three eyes from three patients with biopsy-proven PIOL and retinal infiltrations were reviewed. The SD-OCT and fluorescein angiographic findings were evaluated in the three eyes and FAF images in two eyes.Results: The PIOL in the three patients was monocular. Vitreous opacities and retinal infiltrations were observed in the three eyes, and iritis was present in two eyes. The cytologic diagnosis was class V in two eyes and class III in one eye. The interleukin-10/interleukin-6 ratio was >1.0 in the vitreous and aqueous humor of the three eyes. The FAF images for two eyes showed abnormal granular hyperautofluorescence and hypoautofluorescence which were the reverse of the pattern in the fluorescein angiographic images. In all three eyes, SD-OCT showed hyper-reflective infiltrations at the level of the retinal pigment epithelium (RPE), a separation of the Bruch membrane from the RPE, damage to the RPE, disruption of the photoreceptor inner segment/outer segment junction, and multiple hyper-reflective signals in the inner retina.Conclusion: Because of the characteristic FAF and SD-OCT findings in these eyes with PIOL, we suggest that these noninvasive methods may be used for a rapid diagnosis of PIOL and also for understanding the pathology of PIOL.Keywords: spectral-domain optical coherence tomography, fundus autofluorescence, primary intraocular lymphoma
format	article
author	Egawa M Mitamura Y Hayashi Y Naito T
author_facet	Egawa M Mitamura Y Hayashi Y Naito T
author_sort	Egawa M
title	Spectral-domain optical coherence tomographic and fundus autofluorescence findings in eyes with primary intraocular lymphoma
title_short	Spectral-domain optical coherence tomographic and fundus autofluorescence findings in eyes with primary intraocular lymphoma
title_full	Spectral-domain optical coherence tomographic and fundus autofluorescence findings in eyes with primary intraocular lymphoma
title_fullStr	Spectral-domain optical coherence tomographic and fundus autofluorescence findings in eyes with primary intraocular lymphoma
title_full_unstemmed	Spectral-domain optical coherence tomographic and fundus autofluorescence findings in eyes with primary intraocular lymphoma
title_sort	spectral-domain optical coherence tomographic and fundus autofluorescence findings in eyes with primary intraocular lymphoma
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/581733b23ee04606abce493c1f431442
work_keys_str_mv	AT egawam spectraldomainopticalcoherencetomographicandfundusautofluorescencefindingsineyeswithprimaryintraocularlymphoma AT mitamuray spectraldomainopticalcoherencetomographicandfundusautofluorescencefindingsineyeswithprimaryintraocularlymphoma AT hayashiy spectraldomainopticalcoherencetomographicandfundusautofluorescencefindingsineyeswithprimaryintraocularlymphoma AT naitot spectraldomainopticalcoherencetomographicandfundusautofluorescencefindingsineyeswithprimaryintraocularlymphoma
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Spectral-domain optical coherence tomographic and fundus autofluorescence findings in eyes with primary intraocular lymphoma

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