LIG4 mediates Wnt signalling-induced radioresistance

The Wnt/β-catenin signalling pathway contributes to radio resistance in intestinal stem cells but the underlying mechanism is currently unknown. In this study, the authors demonstrate that LIG4, a DNA ligase involved in the DNA repair process, is a direct target of β-catenin and it specifically medi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sohee Jun, Youn-Sang Jung, Han Na Suh, Wenqi Wang, Moon Jong Kim, Young Sun Oh, Esther M. Lien, Xi Shen, Yoshihisa Matsumoto, Pierre D. McCrea, Lei Li, Junjie Chen, Jae-Il Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/581765a279824025a9bb4b79da323deb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:581765a279824025a9bb4b79da323deb
record_format	dspace
spelling	oai:doaj.org-article:581765a279824025a9bb4b79da323deb2021-12-02T15:35:46ZLIG4 mediates Wnt signalling-induced radioresistance10.1038/ncomms109942041-1723https://doaj.org/article/581765a279824025a9bb4b79da323deb2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10994https://doaj.org/toc/2041-1723The Wnt/β-catenin signalling pathway contributes to radio resistance in intestinal stem cells but the underlying mechanism is currently unknown. In this study, the authors demonstrate that LIG4, a DNA ligase involved in the DNA repair process, is a direct target of β-catenin and it specifically mediates non-homologous end joining repair in colorectal cancer cells.Sohee JunYoun-Sang JungHan Na SuhWenqi WangMoon Jong KimYoung Sun OhEsther M. LienXi ShenYoshihisa MatsumotoPierre D. McCreaLei LiJunjie ChenJae-Il ParkNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sohee Jun Youn-Sang Jung Han Na Suh Wenqi Wang Moon Jong Kim Young Sun Oh Esther M. Lien Xi Shen Yoshihisa Matsumoto Pierre D. McCrea Lei Li Junjie Chen Jae-Il Park LIG4 mediates Wnt signalling-induced radioresistance
description	The Wnt/β-catenin signalling pathway contributes to radio resistance in intestinal stem cells but the underlying mechanism is currently unknown. In this study, the authors demonstrate that LIG4, a DNA ligase involved in the DNA repair process, is a direct target of β-catenin and it specifically mediates non-homologous end joining repair in colorectal cancer cells.
format	article
author	Sohee Jun Youn-Sang Jung Han Na Suh Wenqi Wang Moon Jong Kim Young Sun Oh Esther M. Lien Xi Shen Yoshihisa Matsumoto Pierre D. McCrea Lei Li Junjie Chen Jae-Il Park
author_facet	Sohee Jun Youn-Sang Jung Han Na Suh Wenqi Wang Moon Jong Kim Young Sun Oh Esther M. Lien Xi Shen Yoshihisa Matsumoto Pierre D. McCrea Lei Li Junjie Chen Jae-Il Park
author_sort	Sohee Jun
title	LIG4 mediates Wnt signalling-induced radioresistance
title_short	LIG4 mediates Wnt signalling-induced radioresistance
title_full	LIG4 mediates Wnt signalling-induced radioresistance
title_fullStr	LIG4 mediates Wnt signalling-induced radioresistance
title_full_unstemmed	LIG4 mediates Wnt signalling-induced radioresistance
title_sort	lig4 mediates wnt signalling-induced radioresistance
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/581765a279824025a9bb4b79da323deb
work_keys_str_mv	AT soheejun lig4mediateswntsignallinginducedradioresistance AT younsangjung lig4mediateswntsignallinginducedradioresistance AT hannasuh lig4mediateswntsignallinginducedradioresistance AT wenqiwang lig4mediateswntsignallinginducedradioresistance AT moonjongkim lig4mediateswntsignallinginducedradioresistance AT youngsunoh lig4mediateswntsignallinginducedradioresistance AT esthermlien lig4mediateswntsignallinginducedradioresistance AT xishen lig4mediateswntsignallinginducedradioresistance AT yoshihisamatsumoto lig4mediateswntsignallinginducedradioresistance AT pierredmccrea lig4mediateswntsignallinginducedradioresistance AT leili lig4mediateswntsignallinginducedradioresistance AT junjiechen lig4mediateswntsignallinginducedradioresistance AT jaeilpark lig4mediateswntsignallinginducedradioresistance
_version_	1718386473325035520

LIG4 mediates Wnt signalling-induced radioresistance

Ejemplares similares