Syntenin-knock out reduces exosome turnover and viral transduction

Abstract Exosomal transfers represent an important mode of intercellular communication. Syntenin is a small scaffold protein that, when binding ALIX, can direct endocytosed syndecans and syndecan cargo to budding endosomal membranes, supporting the formation of intraluminal vesicles that compose the...

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Autores principales:	Rudra Kashyap, Marielle Balzano, Benoit Lechat, Kathleen Lambaerts, Antonio Luis Egea-Jimenez, Frédérique Lembo, Joanna Fares, Sofie Meeussen, Sebastian Kügler, Anton Roebroek, Guido David, Pascale Zimmermann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5818175db7fd4b9fba6c41d314e2d576
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spelling	oai:doaj.org-article:5818175db7fd4b9fba6c41d314e2d5762021-12-02T10:54:30ZSyntenin-knock out reduces exosome turnover and viral transduction10.1038/s41598-021-81697-42045-2322https://doaj.org/article/5818175db7fd4b9fba6c41d314e2d5762021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81697-4https://doaj.org/toc/2045-2322Abstract Exosomal transfers represent an important mode of intercellular communication. Syntenin is a small scaffold protein that, when binding ALIX, can direct endocytosed syndecans and syndecan cargo to budding endosomal membranes, supporting the formation of intraluminal vesicles that compose the source of a major class of exosomes. Syntenin, however, can also support the recycling of these same components to the cell surface. Here, by studying mice and cells with syntenin-knock out, we identify syntenin as part of dedicated machinery that integrates both the production and the uptake of secreted vesicles, supporting viral/exosomal exchanges. This study significantly extends the emerging role of heparan sulfate proteoglycans and syntenin as key components for macromolecular cargo internalization into cells.Rudra KashyapMarielle BalzanoBenoit LechatKathleen LambaertsAntonio Luis Egea-JimenezFrédérique LemboJoanna FaresSofie MeeussenSebastian KüglerAnton RoebroekGuido DavidPascale ZimmermannNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rudra Kashyap Marielle Balzano Benoit Lechat Kathleen Lambaerts Antonio Luis Egea-Jimenez Frédérique Lembo Joanna Fares Sofie Meeussen Sebastian Kügler Anton Roebroek Guido David Pascale Zimmermann Syntenin-knock out reduces exosome turnover and viral transduction
description	Abstract Exosomal transfers represent an important mode of intercellular communication. Syntenin is a small scaffold protein that, when binding ALIX, can direct endocytosed syndecans and syndecan cargo to budding endosomal membranes, supporting the formation of intraluminal vesicles that compose the source of a major class of exosomes. Syntenin, however, can also support the recycling of these same components to the cell surface. Here, by studying mice and cells with syntenin-knock out, we identify syntenin as part of dedicated machinery that integrates both the production and the uptake of secreted vesicles, supporting viral/exosomal exchanges. This study significantly extends the emerging role of heparan sulfate proteoglycans and syntenin as key components for macromolecular cargo internalization into cells.
format	article
author	Rudra Kashyap Marielle Balzano Benoit Lechat Kathleen Lambaerts Antonio Luis Egea-Jimenez Frédérique Lembo Joanna Fares Sofie Meeussen Sebastian Kügler Anton Roebroek Guido David Pascale Zimmermann
author_facet	Rudra Kashyap Marielle Balzano Benoit Lechat Kathleen Lambaerts Antonio Luis Egea-Jimenez Frédérique Lembo Joanna Fares Sofie Meeussen Sebastian Kügler Anton Roebroek Guido David Pascale Zimmermann
author_sort	Rudra Kashyap
title	Syntenin-knock out reduces exosome turnover and viral transduction
title_short	Syntenin-knock out reduces exosome turnover and viral transduction
title_full	Syntenin-knock out reduces exosome turnover and viral transduction
title_fullStr	Syntenin-knock out reduces exosome turnover and viral transduction
title_full_unstemmed	Syntenin-knock out reduces exosome turnover and viral transduction
title_sort	syntenin-knock out reduces exosome turnover and viral transduction
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5818175db7fd4b9fba6c41d314e2d576
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Syntenin-knock out reduces exosome turnover and viral transduction

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