Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in schizophrenic patients.
Schizophrenia is a complex psychiatric disorder characterized by positive symptoms, negative symptoms, and cognitive impairment. MAGI2, a relatively large gene (∼1.5 Mbps) that maps to chromosome 7q21, is involved in recruitment of neurotransmitter receptors such as AMPA- and NMDA-type glutamate rec...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2012
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/5819277ab3d24b609906f60d57599850 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:5819277ab3d24b609906f60d57599850 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:5819277ab3d24b609906f60d575998502021-11-18T07:17:44ZCommon variants in MAGI2 gene are associated with increased risk for cognitive impairment in schizophrenic patients.1932-620310.1371/journal.pone.0036836https://doaj.org/article/5819277ab3d24b609906f60d575998502012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22649501/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Schizophrenia is a complex psychiatric disorder characterized by positive symptoms, negative symptoms, and cognitive impairment. MAGI2, a relatively large gene (∼1.5 Mbps) that maps to chromosome 7q21, is involved in recruitment of neurotransmitter receptors such as AMPA- and NMDA-type glutamate receptors. A genetic association study designed to evaluate the association between MAGI2 and cognitive performance or schizophrenia has not been conducted. In this case-control study, we examined the relationship of single nucleotide polymorphism (SNP) variations in MAGI2 and risk for schizophrenia in a large Japanese sample and explored the potential relationships between variations in MAGI2 and aspects of human cognitive function related to glutamate activity. Based on the result of first schizophrenia genome-wide association study in a Japanese population (JGWAS), we selected four independent SNPs and performed an association study using a large independent Japanese sample set (cases 1624, controls 1621). Wisconsin Card Sorting Test (WCST) was used to evaluate executive function in 114 cases and 91 controls. We found suggestive evidence for genetic association of common SNPs within MAGI2 locus and schizophrenia in Japanese population. Furthermore in terms of association between MAGI2 and cognitive performance, we observed that genotype effect of rs2190665 on WCST score was significant (p = 0.034) and rs4729938 trended toward significance (p = 0.08). In conclusion, although we could not detect strong genetic evidence for association of common variants in MAGI2 and increased schizophrenia risk in a Japanese population, these SNPs may increase risk of cognitive impairment in schizophrenic patients.Takayoshi KoideMasahiro BannoBranko AleksicSaori YamashitaTsutomu KikuchiKunihiro KohmuraYasunori AdachiNaoko KawanoItaru KushimaYukako NakamuraTakashi OkadaMasashi IkedaKazutaka OhiYuka YasudaRyota HashimotoToshiya InadaHiroshi UjikeTetsuya IidakaMichio SuzukiMasatoshi TakedaNakao IwataNorio OzakiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 5, p e36836 (2012) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Takayoshi Koide Masahiro Banno Branko Aleksic Saori Yamashita Tsutomu Kikuchi Kunihiro Kohmura Yasunori Adachi Naoko Kawano Itaru Kushima Yukako Nakamura Takashi Okada Masashi Ikeda Kazutaka Ohi Yuka Yasuda Ryota Hashimoto Toshiya Inada Hiroshi Ujike Tetsuya Iidaka Michio Suzuki Masatoshi Takeda Nakao Iwata Norio Ozaki Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in schizophrenic patients. |
| description |
Schizophrenia is a complex psychiatric disorder characterized by positive symptoms, negative symptoms, and cognitive impairment. MAGI2, a relatively large gene (∼1.5 Mbps) that maps to chromosome 7q21, is involved in recruitment of neurotransmitter receptors such as AMPA- and NMDA-type glutamate receptors. A genetic association study designed to evaluate the association between MAGI2 and cognitive performance or schizophrenia has not been conducted. In this case-control study, we examined the relationship of single nucleotide polymorphism (SNP) variations in MAGI2 and risk for schizophrenia in a large Japanese sample and explored the potential relationships between variations in MAGI2 and aspects of human cognitive function related to glutamate activity. Based on the result of first schizophrenia genome-wide association study in a Japanese population (JGWAS), we selected four independent SNPs and performed an association study using a large independent Japanese sample set (cases 1624, controls 1621). Wisconsin Card Sorting Test (WCST) was used to evaluate executive function in 114 cases and 91 controls. We found suggestive evidence for genetic association of common SNPs within MAGI2 locus and schizophrenia in Japanese population. Furthermore in terms of association between MAGI2 and cognitive performance, we observed that genotype effect of rs2190665 on WCST score was significant (p = 0.034) and rs4729938 trended toward significance (p = 0.08). In conclusion, although we could not detect strong genetic evidence for association of common variants in MAGI2 and increased schizophrenia risk in a Japanese population, these SNPs may increase risk of cognitive impairment in schizophrenic patients. |
| format |
article |
| author |
Takayoshi Koide Masahiro Banno Branko Aleksic Saori Yamashita Tsutomu Kikuchi Kunihiro Kohmura Yasunori Adachi Naoko Kawano Itaru Kushima Yukako Nakamura Takashi Okada Masashi Ikeda Kazutaka Ohi Yuka Yasuda Ryota Hashimoto Toshiya Inada Hiroshi Ujike Tetsuya Iidaka Michio Suzuki Masatoshi Takeda Nakao Iwata Norio Ozaki |
| author_facet |
Takayoshi Koide Masahiro Banno Branko Aleksic Saori Yamashita Tsutomu Kikuchi Kunihiro Kohmura Yasunori Adachi Naoko Kawano Itaru Kushima Yukako Nakamura Takashi Okada Masashi Ikeda Kazutaka Ohi Yuka Yasuda Ryota Hashimoto Toshiya Inada Hiroshi Ujike Tetsuya Iidaka Michio Suzuki Masatoshi Takeda Nakao Iwata Norio Ozaki |
| author_sort |
Takayoshi Koide |
| title |
Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in schizophrenic patients. |
| title_short |
Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in schizophrenic patients. |
| title_full |
Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in schizophrenic patients. |
| title_fullStr |
Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in schizophrenic patients. |
| title_full_unstemmed |
Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in schizophrenic patients. |
| title_sort |
common variants in magi2 gene are associated with increased risk for cognitive impairment in schizophrenic patients. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/5819277ab3d24b609906f60d57599850 |
| work_keys_str_mv |
AT takayoshikoide commonvariantsinmagi2geneareassociatedwithincreasedriskforcognitiveimpairmentinschizophrenicpatients AT masahirobanno commonvariantsinmagi2geneareassociatedwithincreasedriskforcognitiveimpairmentinschizophrenicpatients AT brankoaleksic commonvariantsinmagi2geneareassociatedwithincreasedriskforcognitiveimpairmentinschizophrenicpatients AT saoriyamashita commonvariantsinmagi2geneareassociatedwithincreasedriskforcognitiveimpairmentinschizophrenicpatients AT tsutomukikuchi commonvariantsinmagi2geneareassociatedwithincreasedriskforcognitiveimpairmentinschizophrenicpatients AT kunihirokohmura commonvariantsinmagi2geneareassociatedwithincreasedriskforcognitiveimpairmentinschizophrenicpatients AT yasunoriadachi commonvariantsinmagi2geneareassociatedwithincreasedriskforcognitiveimpairmentinschizophrenicpatients AT naokokawano commonvariantsinmagi2geneareassociatedwithincreasedriskforcognitiveimpairmentinschizophrenicpatients AT itarukushima commonvariantsinmagi2geneareassociatedwithincreasedriskforcognitiveimpairmentinschizophrenicpatients AT yukakonakamura commonvariantsinmagi2geneareassociatedwithincreasedriskforcognitiveimpairmentinschizophrenicpatients AT takashiokada commonvariantsinmagi2geneareassociatedwithincreasedriskforcognitiveimpairmentinschizophrenicpatients AT masashiikeda commonvariantsinmagi2geneareassociatedwithincreasedriskforcognitiveimpairmentinschizophrenicpatients AT kazutakaohi commonvariantsinmagi2geneareassociatedwithincreasedriskforcognitiveimpairmentinschizophrenicpatients AT yukayasuda commonvariantsinmagi2geneareassociatedwithincreasedriskforcognitiveimpairmentinschizophrenicpatients AT ryotahashimoto commonvariantsinmagi2geneareassociatedwithincreasedriskforcognitiveimpairmentinschizophrenicpatients AT toshiyainada commonvariantsinmagi2geneareassociatedwithincreasedriskforcognitiveimpairmentinschizophrenicpatients AT hiroshiujike commonvariantsinmagi2geneareassociatedwithincreasedriskforcognitiveimpairmentinschizophrenicpatients AT tetsuyaiidaka commonvariantsinmagi2geneareassociatedwithincreasedriskforcognitiveimpairmentinschizophrenicpatients AT michiosuzuki commonvariantsinmagi2geneareassociatedwithincreasedriskforcognitiveimpairmentinschizophrenicpatients AT masatoshitakeda commonvariantsinmagi2geneareassociatedwithincreasedriskforcognitiveimpairmentinschizophrenicpatients AT nakaoiwata commonvariantsinmagi2geneareassociatedwithincreasedriskforcognitiveimpairmentinschizophrenicpatients AT norioozaki commonvariantsinmagi2geneareassociatedwithincreasedriskforcognitiveimpairmentinschizophrenicpatients |
| _version_ |
1718423664527933440 |