Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism

The mechanisms behind the plasticity of embryos and how they deal with aneuploid cells are unclear. Here, the authors show that aneuploid cells in a mouse embryo are preferentially eliminated during pre- and peri-implantation development in a p53-dependent process involving both autophagy and apopto...

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Autores principales:	Shruti Singla, Lisa K. Iwamoto-Stohl, Meng Zhu, Magdalena Zernicka-Goetz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/581a6aee0696437ca64ad121b80a3b63
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spelling	oai:doaj.org-article:581a6aee0696437ca64ad121b80a3b632021-12-02T17:52:20ZAutophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism10.1038/s41467-020-16796-32041-1723https://doaj.org/article/581a6aee0696437ca64ad121b80a3b632020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16796-3https://doaj.org/toc/2041-1723The mechanisms behind the plasticity of embryos and how they deal with aneuploid cells are unclear. Here, the authors show that aneuploid cells in a mouse embryo are preferentially eliminated during pre- and peri-implantation development in a p53-dependent process involving both autophagy and apoptosis.Shruti SinglaLisa K. Iwamoto-StohlMeng ZhuMagdalena Zernicka-GoetzNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shruti Singla Lisa K. Iwamoto-Stohl Meng Zhu Magdalena Zernicka-Goetz Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism
description	The mechanisms behind the plasticity of embryos and how they deal with aneuploid cells are unclear. Here, the authors show that aneuploid cells in a mouse embryo are preferentially eliminated during pre- and peri-implantation development in a p53-dependent process involving both autophagy and apoptosis.
format	article
author	Shruti Singla Lisa K. Iwamoto-Stohl Meng Zhu Magdalena Zernicka-Goetz
author_facet	Shruti Singla Lisa K. Iwamoto-Stohl Meng Zhu Magdalena Zernicka-Goetz
author_sort	Shruti Singla
title	Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism
title_short	Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism
title_full	Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism
title_fullStr	Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism
title_full_unstemmed	Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism
title_sort	autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/581a6aee0696437ca64ad121b80a3b63
work_keys_str_mv	AT shrutisingla autophagymediatedapoptosiseliminatesaneuploidcellsinamousemodelofchromosomemosaicism AT lisakiwamotostohl autophagymediatedapoptosiseliminatesaneuploidcellsinamousemodelofchromosomemosaicism AT mengzhu autophagymediatedapoptosiseliminatesaneuploidcellsinamousemodelofchromosomemosaicism AT magdalenazernickagoetz autophagymediatedapoptosiseliminatesaneuploidcellsinamousemodelofchromosomemosaicism
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Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism

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