Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism
The mechanisms behind the plasticity of embryos and how they deal with aneuploid cells are unclear. Here, the authors show that aneuploid cells in a mouse embryo are preferentially eliminated during pre- and peri-implantation development in a p53-dependent process involving both autophagy and apopto...
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Autores principales: | Shruti Singla, Lisa K. Iwamoto-Stohl, Meng Zhu, Magdalena Zernicka-Goetz |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
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Materias: | |
Acceso en línea: | https://doaj.org/article/581a6aee0696437ca64ad121b80a3b63 |
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