Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism

The mechanisms behind the plasticity of embryos and how they deal with aneuploid cells are unclear. Here, the authors show that aneuploid cells in a mouse embryo are preferentially eliminated during pre- and peri-implantation development in a p53-dependent process involving both autophagy and apopto...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Shruti Singla, Lisa K. Iwamoto-Stohl, Meng Zhu, Magdalena Zernicka-Goetz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Q
Acceso en línea:https://doaj.org/article/581a6aee0696437ca64ad121b80a3b63
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares