Bisphenol A and Its Analogues Deteriorate the Hormones Physiological Function of the Male Reproductive System: A Mini-Review

BPA is identified as an endocrine-disrupting chemical that deteriorates the physiological function of the hormones of the male reproductive system. Bisphenol F (BPF), bisphenol S (BPS), and bisphenol AF (BPAF) are actively explored as substitutes for BPA and are known as BPA analogues in most manufa...

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Autores principales:	Asma’ ‘Afifah Shamhari, Zariyantey Abd Hamid, Siti Balkis Budin, Nurul Jehan Shamsudin, Izatus Shima Taib
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	aromatase bisphenol F bisphenol AF bisphenol S HPG axis steroidogenesis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/581a73291c8645ab95cc87ea099ac2af
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id	oai:doaj.org-article:581a73291c8645ab95cc87ea099ac2af
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spelling	oai:doaj.org-article:581a73291c8645ab95cc87ea099ac2af2021-11-25T16:51:40ZBisphenol A and Its Analogues Deteriorate the Hormones Physiological Function of the Male Reproductive System: A Mini-Review10.3390/biomedicines91117442227-9059https://doaj.org/article/581a73291c8645ab95cc87ea099ac2af2021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1744https://doaj.org/toc/2227-9059BPA is identified as an endocrine-disrupting chemical that deteriorates the physiological function of the hormones of the male reproductive system. Bisphenol F (BPF), bisphenol S (BPS), and bisphenol AF (BPAF) are actively explored as substitutes for BPA and are known as BPA analogues in most manufacturing industries. These analogues may demonstrate the same adverse effects as BPA on the male reproductive system; however, toxicological data explaining the male reproductive hormones’ physiological functions are still limited. Hence, this mini-review discusses the effects of BPA and its analogues on the physiological functions of hormones in the male reproductive system, focusing on the hypothalamus-pituitary-gonad (HPG) axis, steroidogenesis, and spermatogenesis outcomes. The BPA analogues mainly show a similar negative effect on the hormones’ physiological functions, proven by alterations in the HPG axis and steroidogenesis via activation of the aromatase activity and reduction of spermatogenesis outcomes when compared to BPA in in vitro and in vivo studies. Human biomonitoring studies also provide significant adverse effects on the physiological functions of hormones in the male reproductive system. In conclusion, BPA and its analogues deteriorate the physiological functions of hormones in the male reproductive system as per in vitro, in vivo, and human biomonitoring studies.Asma’ ‘Afifah ShamhariZariyantey Abd HamidSiti Balkis BudinNurul Jehan ShamsudinIzatus Shima TaibMDPI AGarticlearomatasebisphenol Fbisphenol AFbisphenol SHPG axissteroidogenesisBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1744, p 1744 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aromatase bisphenol F bisphenol AF bisphenol S HPG axis steroidogenesis Biology (General) QH301-705.5
spellingShingle	aromatase bisphenol F bisphenol AF bisphenol S HPG axis steroidogenesis Biology (General) QH301-705.5 Asma’ ‘Afifah Shamhari Zariyantey Abd Hamid Siti Balkis Budin Nurul Jehan Shamsudin Izatus Shima Taib Bisphenol A and Its Analogues Deteriorate the Hormones Physiological Function of the Male Reproductive System: A Mini-Review
description	BPA is identified as an endocrine-disrupting chemical that deteriorates the physiological function of the hormones of the male reproductive system. Bisphenol F (BPF), bisphenol S (BPS), and bisphenol AF (BPAF) are actively explored as substitutes for BPA and are known as BPA analogues in most manufacturing industries. These analogues may demonstrate the same adverse effects as BPA on the male reproductive system; however, toxicological data explaining the male reproductive hormones’ physiological functions are still limited. Hence, this mini-review discusses the effects of BPA and its analogues on the physiological functions of hormones in the male reproductive system, focusing on the hypothalamus-pituitary-gonad (HPG) axis, steroidogenesis, and spermatogenesis outcomes. The BPA analogues mainly show a similar negative effect on the hormones’ physiological functions, proven by alterations in the HPG axis and steroidogenesis via activation of the aromatase activity and reduction of spermatogenesis outcomes when compared to BPA in in vitro and in vivo studies. Human biomonitoring studies also provide significant adverse effects on the physiological functions of hormones in the male reproductive system. In conclusion, BPA and its analogues deteriorate the physiological functions of hormones in the male reproductive system as per in vitro, in vivo, and human biomonitoring studies.
format	article
author	Asma’ ‘Afifah Shamhari Zariyantey Abd Hamid Siti Balkis Budin Nurul Jehan Shamsudin Izatus Shima Taib
author_facet	Asma’ ‘Afifah Shamhari Zariyantey Abd Hamid Siti Balkis Budin Nurul Jehan Shamsudin Izatus Shima Taib
author_sort	Asma’ ‘Afifah Shamhari
title	Bisphenol A and Its Analogues Deteriorate the Hormones Physiological Function of the Male Reproductive System: A Mini-Review
title_short	Bisphenol A and Its Analogues Deteriorate the Hormones Physiological Function of the Male Reproductive System: A Mini-Review
title_full	Bisphenol A and Its Analogues Deteriorate the Hormones Physiological Function of the Male Reproductive System: A Mini-Review
title_fullStr	Bisphenol A and Its Analogues Deteriorate the Hormones Physiological Function of the Male Reproductive System: A Mini-Review
title_full_unstemmed	Bisphenol A and Its Analogues Deteriorate the Hormones Physiological Function of the Male Reproductive System: A Mini-Review
title_sort	bisphenol a and its analogues deteriorate the hormones physiological function of the male reproductive system: a mini-review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/581a73291c8645ab95cc87ea099ac2af
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Bisphenol A and Its Analogues Deteriorate the Hormones Physiological Function of the Male Reproductive System: A Mini-Review

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