A Melanin-like Nanoenzyme for Acute Lung Injury Therapy via Suppressing Oxidative and Endoplasmic Reticulum Stress Response

Nanoenzyme-mediated catalytic activity is emerging as a novel strategy for reactive oxygen species (ROS) scavenging in acute lung injury (ALI) treatment. However, one of the main hurdles for these metal-containing nanoenzymes is their potential toxicity and single therapeutic mechanism. Herein, we u...

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Autores principales:	Xue-Fang Lou, Chen Wang, Ju-Cong Zhang, Yong-Zhong Du, Xiao-Ling Xu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	melanin-like nanoenzyme acute lung injury endoplasmic reticulum stress oxidative stress 1,8-DHN polymerized nanoparticles Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/581bce619188451ea5c88e9dc7fce78e
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spelling	oai:doaj.org-article:581bce619188451ea5c88e9dc7fce78e2021-11-25T18:41:08ZA Melanin-like Nanoenzyme for Acute Lung Injury Therapy via Suppressing Oxidative and Endoplasmic Reticulum Stress Response10.3390/pharmaceutics131118501999-4923https://doaj.org/article/581bce619188451ea5c88e9dc7fce78e2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1850https://doaj.org/toc/1999-4923Nanoenzyme-mediated catalytic activity is emerging as a novel strategy for reactive oxygen species (ROS) scavenging in acute lung injury (ALI) treatment. However, one of the main hurdles for these metal-containing nanoenzymes is their potential toxicity and single therapeutic mechanism. Herein, we uncovered a melanin-like nanoparticles derived from the self-polymerization of 1,8-dihydroxynaphthalene (PDH nanoparticles), showing a significant anti-inflammation therapeutic effect on ALI mice. The prepared PDH nanoparticles rich in phenol groups could not only act as radical scavengers to alleviate oxidative stress but could also chelate calcium overload to suppress the endoplasmic reticulum stress response. As revealed by the therapeutic effect in vivo, PDH nanoparticles significantly prohibited neutrophil infiltration and the secretion of proinflammatory cytokines (TNF-α and IL-6), thus improving the inflammatory cascade in the ALI model. Above all, our work provides an effective anti-inflammatory nanoplatform by using the inherent capability of melanin-like nanoenzymes, proposing the potential application prospects of these melanin-like nanoparticles for acute inflammation-induced injury treatment.Xue-Fang LouChen WangJu-Cong ZhangYong-Zhong DuXiao-Ling XuMDPI AGarticlemelanin-like nanoenzymeacute lung injuryendoplasmic reticulum stressoxidative stress1,8-DHN polymerized nanoparticlesPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1850, p 1850 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	melanin-like nanoenzyme acute lung injury endoplasmic reticulum stress oxidative stress 1,8-DHN polymerized nanoparticles Pharmacy and materia medica RS1-441
spellingShingle	melanin-like nanoenzyme acute lung injury endoplasmic reticulum stress oxidative stress 1,8-DHN polymerized nanoparticles Pharmacy and materia medica RS1-441 Xue-Fang Lou Chen Wang Ju-Cong Zhang Yong-Zhong Du Xiao-Ling Xu A Melanin-like Nanoenzyme for Acute Lung Injury Therapy via Suppressing Oxidative and Endoplasmic Reticulum Stress Response
description	Nanoenzyme-mediated catalytic activity is emerging as a novel strategy for reactive oxygen species (ROS) scavenging in acute lung injury (ALI) treatment. However, one of the main hurdles for these metal-containing nanoenzymes is their potential toxicity and single therapeutic mechanism. Herein, we uncovered a melanin-like nanoparticles derived from the self-polymerization of 1,8-dihydroxynaphthalene (PDH nanoparticles), showing a significant anti-inflammation therapeutic effect on ALI mice. The prepared PDH nanoparticles rich in phenol groups could not only act as radical scavengers to alleviate oxidative stress but could also chelate calcium overload to suppress the endoplasmic reticulum stress response. As revealed by the therapeutic effect in vivo, PDH nanoparticles significantly prohibited neutrophil infiltration and the secretion of proinflammatory cytokines (TNF-α and IL-6), thus improving the inflammatory cascade in the ALI model. Above all, our work provides an effective anti-inflammatory nanoplatform by using the inherent capability of melanin-like nanoenzymes, proposing the potential application prospects of these melanin-like nanoparticles for acute inflammation-induced injury treatment.
format	article
author	Xue-Fang Lou Chen Wang Ju-Cong Zhang Yong-Zhong Du Xiao-Ling Xu
author_facet	Xue-Fang Lou Chen Wang Ju-Cong Zhang Yong-Zhong Du Xiao-Ling Xu
author_sort	Xue-Fang Lou
title	A Melanin-like Nanoenzyme for Acute Lung Injury Therapy via Suppressing Oxidative and Endoplasmic Reticulum Stress Response
title_short	A Melanin-like Nanoenzyme for Acute Lung Injury Therapy via Suppressing Oxidative and Endoplasmic Reticulum Stress Response
title_full	A Melanin-like Nanoenzyme for Acute Lung Injury Therapy via Suppressing Oxidative and Endoplasmic Reticulum Stress Response
title_fullStr	A Melanin-like Nanoenzyme for Acute Lung Injury Therapy via Suppressing Oxidative and Endoplasmic Reticulum Stress Response
title_full_unstemmed	A Melanin-like Nanoenzyme for Acute Lung Injury Therapy via Suppressing Oxidative and Endoplasmic Reticulum Stress Response
title_sort	melanin-like nanoenzyme for acute lung injury therapy via suppressing oxidative and endoplasmic reticulum stress response
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/581bce619188451ea5c88e9dc7fce78e
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A Melanin-like Nanoenzyme for Acute Lung Injury Therapy via Suppressing Oxidative and Endoplasmic Reticulum Stress Response

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