Incidence and Risk Factors Associated with Retinopathy of Prematurity in Peru

Carmen Sarita Carranza-Mendizabal,1,2 Mariela Diaz-Manrique,1,2 Percy G Ruiz Mamani,3 Michael White,4 Salomon Huancahuire-Vega2,4 1Ophthalmology Service, Hipólito Unanue National Hospital, Lima, Peru; 2Human Medicine School, Peruvian Union University (UPeU), Lima, Peru; 3San Juan Bautista...

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Autores principales:	Carranza-Mendizabal CS, Diaz-Manrique M, Ruiz Mamani PG, White M, Huancahuire-Vega S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	retinopathy of prematurity gestational age sepsis birth weight anemia exclusive breastfeeding Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/581c65d44fac47268c9df18643d295ab
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spelling	oai:doaj.org-article:581c65d44fac47268c9df18643d295ab2021-12-02T14:37:09ZIncidence and Risk Factors Associated with Retinopathy of Prematurity in Peru1177-5483https://doaj.org/article/581c65d44fac47268c9df18643d295ab2021-05-01T00:00:00Zhttps://www.dovepress.com/incidence-and-risk-factors-associated-with-retinopathy-of-prematurity--peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Carmen Sarita Carranza-Mendizabal,1,2 Mariela Diaz-Manrique,1,2 Percy G Ruiz Mamani,3 Michael White,4 Salomon Huancahuire-Vega2,4 1Ophthalmology Service, Hipólito Unanue National Hospital, Lima, Peru; 2Human Medicine School, Peruvian Union University (UPeU), Lima, Peru; 3San Juan Bautista Private University, Lima, Peru; 4Directorate General Research, Peruvian Union University (UPeU), Lima, PeruCorrespondence: Salomon Huancahuire-VegaHuman Medicine School, Peruvian Union University (UPeU), Carretera Central Km 19 Ñaña Lurigancho-Chosica, Lima 15, Lima, PeruTel +51-997574011Email salomonhuancahuire@upeu.edu.pePurpose: The purpose of this research is to determine retinopathy of prematurity (ROP) prevalence and possible risk factors associated with ROP development in newborns admitted to a neonatal unit of a Peruvian National Reference Hospital.Patients and Methods: This retrospective study included 216 preterm infants. The data were collected between January 2016 and December 2018. All infants were examined according to Peruvian guidelines for screening and treatment of ROP. The association of clinical risk factors and the development of ROP was analyzed and predictive factors were determined.Results: The study subjects were 216 preterm infants of which 72 had some stage of ROP (32 stage 1; 23 stage 2 and 17 stage 3) and 144 preterm infants without ROP. The incidence of ROP in preterm infants less than 32 weeks was 60.9%, while for those weighing less than 1500 g it was 71.6%. The factors associated with ROP were gestational age below 32 weeks, birth weight below 1500 grams, neonatal sepsis, oxygen therapy, mechanical ventilation, hyaline membrane disease, bronchopulmonary dysplasia, persistence of ductus arteriosus and intraventricular hemorrhage. Exclusive breastfeeding was found to play a protective role against ROP. Binary logistic regression analysis found that only gestational age below 32 weeks (OR, 2.637; 95% CI, 1.04– 6.69), weight below 1500 grams (OR, 4.377; 95% CI, 1.75– 10.92), neonatal sepsis (OR, 6.517; 95% CI, 2.81– 15.14), vaginal delivery (OR, 3.748; 95% CI: 1.54– 9.14), and the presence of hyaline membrane disease (OR, 3.58; 95% CI, 1.47– 8.74) are predictors of ROP.Conclusion: The incidence of ROP among very low birth weight infants was 71.6%. Infants with weight below 1500 grams, neonatal sepsis, presence of hyaline membrane disease whose mother had vaginal delivery are at risk for the development of ROP. Thus, preventing premature births and encouraging exclusive breastfeeding are two main ways to prevent ROP.Keywords: retinopathy of prematurity, gestational age, sepsis, birth weight, anemia, exclusive breastfeedingCarranza-Mendizabal CSDiaz-Manrique MRuiz Mamani PGWhite MHuancahuire-Vega SDove Medical Pressarticleretinopathy of prematuritygestational agesepsisbirth weightanemiaexclusive breastfeedingOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 2141-2148 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	retinopathy of prematurity gestational age sepsis birth weight anemia exclusive breastfeeding Ophthalmology RE1-994
spellingShingle	retinopathy of prematurity gestational age sepsis birth weight anemia exclusive breastfeeding Ophthalmology RE1-994 Carranza-Mendizabal CS Diaz-Manrique M Ruiz Mamani PG White M Huancahuire-Vega S Incidence and Risk Factors Associated with Retinopathy of Prematurity in Peru
description	Carmen Sarita Carranza-Mendizabal,1,2 Mariela Diaz-Manrique,1,2 Percy G Ruiz Mamani,3 Michael White,4 Salomon Huancahuire-Vega2,4 1Ophthalmology Service, Hipólito Unanue National Hospital, Lima, Peru; 2Human Medicine School, Peruvian Union University (UPeU), Lima, Peru; 3San Juan Bautista Private University, Lima, Peru; 4Directorate General Research, Peruvian Union University (UPeU), Lima, PeruCorrespondence: Salomon Huancahuire-VegaHuman Medicine School, Peruvian Union University (UPeU), Carretera Central Km 19 Ñaña Lurigancho-Chosica, Lima 15, Lima, PeruTel +51-997574011Email salomonhuancahuire@upeu.edu.pePurpose: The purpose of this research is to determine retinopathy of prematurity (ROP) prevalence and possible risk factors associated with ROP development in newborns admitted to a neonatal unit of a Peruvian National Reference Hospital.Patients and Methods: This retrospective study included 216 preterm infants. The data were collected between January 2016 and December 2018. All infants were examined according to Peruvian guidelines for screening and treatment of ROP. The association of clinical risk factors and the development of ROP was analyzed and predictive factors were determined.Results: The study subjects were 216 preterm infants of which 72 had some stage of ROP (32 stage 1; 23 stage 2 and 17 stage 3) and 144 preterm infants without ROP. The incidence of ROP in preterm infants less than 32 weeks was 60.9%, while for those weighing less than 1500 g it was 71.6%. The factors associated with ROP were gestational age below 32 weeks, birth weight below 1500 grams, neonatal sepsis, oxygen therapy, mechanical ventilation, hyaline membrane disease, bronchopulmonary dysplasia, persistence of ductus arteriosus and intraventricular hemorrhage. Exclusive breastfeeding was found to play a protective role against ROP. Binary logistic regression analysis found that only gestational age below 32 weeks (OR, 2.637; 95% CI, 1.04– 6.69), weight below 1500 grams (OR, 4.377; 95% CI, 1.75– 10.92), neonatal sepsis (OR, 6.517; 95% CI, 2.81– 15.14), vaginal delivery (OR, 3.748; 95% CI: 1.54– 9.14), and the presence of hyaline membrane disease (OR, 3.58; 95% CI, 1.47– 8.74) are predictors of ROP.Conclusion: The incidence of ROP among very low birth weight infants was 71.6%. Infants with weight below 1500 grams, neonatal sepsis, presence of hyaline membrane disease whose mother had vaginal delivery are at risk for the development of ROP. Thus, preventing premature births and encouraging exclusive breastfeeding are two main ways to prevent ROP.Keywords: retinopathy of prematurity, gestational age, sepsis, birth weight, anemia, exclusive breastfeeding
format	article
author	Carranza-Mendizabal CS Diaz-Manrique M Ruiz Mamani PG White M Huancahuire-Vega S
author_facet	Carranza-Mendizabal CS Diaz-Manrique M Ruiz Mamani PG White M Huancahuire-Vega S
author_sort	Carranza-Mendizabal CS
title	Incidence and Risk Factors Associated with Retinopathy of Prematurity in Peru
title_short	Incidence and Risk Factors Associated with Retinopathy of Prematurity in Peru
title_full	Incidence and Risk Factors Associated with Retinopathy of Prematurity in Peru
title_fullStr	Incidence and Risk Factors Associated with Retinopathy of Prematurity in Peru
title_full_unstemmed	Incidence and Risk Factors Associated with Retinopathy of Prematurity in Peru
title_sort	incidence and risk factors associated with retinopathy of prematurity in peru
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/581c65d44fac47268c9df18643d295ab
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Incidence and Risk Factors Associated with Retinopathy of Prematurity in Peru

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