Numerical modelling and experimental verification of thermal effects in living cells exposed to high-power pulses of THz radiation

Abstract Exposure of cells or biological tissues to high-power pulses of terahertz (THz) radiation leads to changes in a variety of intracellular processes. However, the role of heating effects due to strong absorption of THz radiation by water molecules still stays unclear. In this study, we perfor...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	D. S. Sitnikov, A. A. Pronkin, I. V. Ilina, V. A. Revkova, M. A. Konoplyannikov, V. A. Kalsin, V. P. Baklaushev
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/581c8e8596904cab9ef0d986117c389e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:581c8e8596904cab9ef0d986117c389e
record_format	dspace
spelling	oai:doaj.org-article:581c8e8596904cab9ef0d986117c389e2021-12-02T14:58:47ZNumerical modelling and experimental verification of thermal effects in living cells exposed to high-power pulses of THz radiation10.1038/s41598-021-96898-02045-2322https://doaj.org/article/581c8e8596904cab9ef0d986117c389e2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96898-0https://doaj.org/toc/2045-2322Abstract Exposure of cells or biological tissues to high-power pulses of terahertz (THz) radiation leads to changes in a variety of intracellular processes. However, the role of heating effects due to strong absorption of THz radiation by water molecules still stays unclear. In this study, we performed numerical modelling in order to estimate the thermal impact on water of a single THz pulse as well as a series of THz pulses. A finite-element (FE) model that provides numerical solutions for the heat conduction equation is employed to compute the temperature increase. A simple expression for temperature estimation in the center of the spot of THz radiation is presented for given frequency and fluence of the THz pulse. It has been demonstrated that thermal effect is determined by either the average power of radiation or by the fluence of a single THz pulse depending on pulse repetition rate. Human dermal fibroblasts have been exposed to THz pulses (with an energy of $$15\,\upmu \hbox {J}$$ 15 μ J and repetition rate of 100 Hz) to estimate the thermal effect. Analysis of heat shock proteins expression has demonstrated no statistically significant difference ( $$p < 0.05$$ p < 0.05 ) between control and experimental groups after 3 h of irradiation.D. S. SitnikovA. A. PronkinI. V. IlinaV. A. RevkovaM. A. KonoplyannikovV. A. KalsinV. P. BaklaushevNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q D. S. Sitnikov A. A. Pronkin I. V. Ilina V. A. Revkova M. A. Konoplyannikov V. A. Kalsin V. P. Baklaushev Numerical modelling and experimental verification of thermal effects in living cells exposed to high-power pulses of THz radiation
description	Abstract Exposure of cells or biological tissues to high-power pulses of terahertz (THz) radiation leads to changes in a variety of intracellular processes. However, the role of heating effects due to strong absorption of THz radiation by water molecules still stays unclear. In this study, we performed numerical modelling in order to estimate the thermal impact on water of a single THz pulse as well as a series of THz pulses. A finite-element (FE) model that provides numerical solutions for the heat conduction equation is employed to compute the temperature increase. A simple expression for temperature estimation in the center of the spot of THz radiation is presented for given frequency and fluence of the THz pulse. It has been demonstrated that thermal effect is determined by either the average power of radiation or by the fluence of a single THz pulse depending on pulse repetition rate. Human dermal fibroblasts have been exposed to THz pulses (with an energy of $$15\,\upmu \hbox {J}$$ 15 μ J and repetition rate of 100 Hz) to estimate the thermal effect. Analysis of heat shock proteins expression has demonstrated no statistically significant difference ( $$p < 0.05$$ p < 0.05 ) between control and experimental groups after 3 h of irradiation.
format	article
author	D. S. Sitnikov A. A. Pronkin I. V. Ilina V. A. Revkova M. A. Konoplyannikov V. A. Kalsin V. P. Baklaushev
author_facet	D. S. Sitnikov A. A. Pronkin I. V. Ilina V. A. Revkova M. A. Konoplyannikov V. A. Kalsin V. P. Baklaushev
author_sort	D. S. Sitnikov
title	Numerical modelling and experimental verification of thermal effects in living cells exposed to high-power pulses of THz radiation
title_short	Numerical modelling and experimental verification of thermal effects in living cells exposed to high-power pulses of THz radiation
title_full	Numerical modelling and experimental verification of thermal effects in living cells exposed to high-power pulses of THz radiation
title_fullStr	Numerical modelling and experimental verification of thermal effects in living cells exposed to high-power pulses of THz radiation
title_full_unstemmed	Numerical modelling and experimental verification of thermal effects in living cells exposed to high-power pulses of THz radiation
title_sort	numerical modelling and experimental verification of thermal effects in living cells exposed to high-power pulses of thz radiation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/581c8e8596904cab9ef0d986117c389e
work_keys_str_mv	AT dssitnikov numericalmodellingandexperimentalverificationofthermaleffectsinlivingcellsexposedtohighpowerpulsesofthzradiation AT aapronkin numericalmodellingandexperimentalverificationofthermaleffectsinlivingcellsexposedtohighpowerpulsesofthzradiation AT ivilina numericalmodellingandexperimentalverificationofthermaleffectsinlivingcellsexposedtohighpowerpulsesofthzradiation AT varevkova numericalmodellingandexperimentalverificationofthermaleffectsinlivingcellsexposedtohighpowerpulsesofthzradiation AT makonoplyannikov numericalmodellingandexperimentalverificationofthermaleffectsinlivingcellsexposedtohighpowerpulsesofthzradiation AT vakalsin numericalmodellingandexperimentalverificationofthermaleffectsinlivingcellsexposedtohighpowerpulsesofthzradiation AT vpbaklaushev numericalmodellingandexperimentalverificationofthermaleffectsinlivingcellsexposedtohighpowerpulsesofthzradiation
_version_	1718389266104451072

Numerical modelling and experimental verification of thermal effects in living cells exposed to high-power pulses of THz radiation

Ejemplares similares