Overexpression of fibulin-3 in tumor tissue predicts poor survival of malignant mesothelioma patients from hand-spinning asbestos exposed area in eastern China

Abstract Fibulin-3 is an extracellular matrix glycoprotein widely expressed in various tissues. Tissue fibulin-3 expression have never been reported in association with prognosis of mesothelioma. Hence, we sought to determine the association between fibulin-3 expression and mesothelioma survival. We...

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Autores principales:	Zhaoqiang Jiang, Wei Shen, Shibo Ying, Zhibin Gao, Xianglei He, Riping Chen, Hailing Xia, Xinnian Guo, Yuan Fang, Yixiao Zhang, Jianjiang Miao, Jian Zhou, Xing Zhang, Junqiang Chen, Jianlin Lou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/581dcb45178e4732b0734e5acddf5304
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spelling	oai:doaj.org-article:581dcb45178e4732b0734e5acddf53042021-12-02T11:40:20ZOverexpression of fibulin-3 in tumor tissue predicts poor survival of malignant mesothelioma patients from hand-spinning asbestos exposed area in eastern China10.1038/s41598-020-77412-42045-2322https://doaj.org/article/581dcb45178e4732b0734e5acddf53042020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77412-4https://doaj.org/toc/2045-2322Abstract Fibulin-3 is an extracellular matrix glycoprotein widely expressed in various tissues. Tissue fibulin-3 expression have never been reported in association with prognosis of mesothelioma. Hence, we sought to determine the association between fibulin-3 expression and mesothelioma survival. We made a tissue microarray, which was comprised of cancer and normal tissue from mesothelioma patients (n = 82) during the period 1998–2017 in China. Fibulin-3 and HGMB1 expression were analyzed by immunohistochemistry method. Kaplan–Meier method and Cox proportional hazard models were used for analyzing survival data. Overall, 61 cases (74.4%) were female; 90.2% were of epithelioid type; the median overall survival time was 12.5 months. Fibulin-3 and HMGB1 were highly expressed in tumor tissue rather than adjacent tissue. The expression of fibulin-3 in tissue was correlated with that of HMGB1 (r = 0.32, P = 0.003). High expression of fibulin-3 in tumor tissue could predict poor survival in patients with mesothelioma (P = 0.02). This remained true in a multivariate model, with a significant hazard ratio of 1.91. We demonstrated that fibulin-3 in tumor tissue was a novel biomarker of poor survival of mesothelioma, suggesting it may be a relevant target for therapeutic intervention.Zhaoqiang JiangWei ShenShibo YingZhibin GaoXianglei HeRiping ChenHailing XiaXinnian GuoYuan FangYixiao ZhangJianjiang MiaoJian ZhouXing ZhangJunqiang ChenJianlin LouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhaoqiang Jiang Wei Shen Shibo Ying Zhibin Gao Xianglei He Riping Chen Hailing Xia Xinnian Guo Yuan Fang Yixiao Zhang Jianjiang Miao Jian Zhou Xing Zhang Junqiang Chen Jianlin Lou Overexpression of fibulin-3 in tumor tissue predicts poor survival of malignant mesothelioma patients from hand-spinning asbestos exposed area in eastern China
description	Abstract Fibulin-3 is an extracellular matrix glycoprotein widely expressed in various tissues. Tissue fibulin-3 expression have never been reported in association with prognosis of mesothelioma. Hence, we sought to determine the association between fibulin-3 expression and mesothelioma survival. We made a tissue microarray, which was comprised of cancer and normal tissue from mesothelioma patients (n = 82) during the period 1998–2017 in China. Fibulin-3 and HGMB1 expression were analyzed by immunohistochemistry method. Kaplan–Meier method and Cox proportional hazard models were used for analyzing survival data. Overall, 61 cases (74.4%) were female; 90.2% were of epithelioid type; the median overall survival time was 12.5 months. Fibulin-3 and HMGB1 were highly expressed in tumor tissue rather than adjacent tissue. The expression of fibulin-3 in tissue was correlated with that of HMGB1 (r = 0.32, P = 0.003). High expression of fibulin-3 in tumor tissue could predict poor survival in patients with mesothelioma (P = 0.02). This remained true in a multivariate model, with a significant hazard ratio of 1.91. We demonstrated that fibulin-3 in tumor tissue was a novel biomarker of poor survival of mesothelioma, suggesting it may be a relevant target for therapeutic intervention.
format	article
author	Zhaoqiang Jiang Wei Shen Shibo Ying Zhibin Gao Xianglei He Riping Chen Hailing Xia Xinnian Guo Yuan Fang Yixiao Zhang Jianjiang Miao Jian Zhou Xing Zhang Junqiang Chen Jianlin Lou
author_facet	Zhaoqiang Jiang Wei Shen Shibo Ying Zhibin Gao Xianglei He Riping Chen Hailing Xia Xinnian Guo Yuan Fang Yixiao Zhang Jianjiang Miao Jian Zhou Xing Zhang Junqiang Chen Jianlin Lou
author_sort	Zhaoqiang Jiang
title	Overexpression of fibulin-3 in tumor tissue predicts poor survival of malignant mesothelioma patients from hand-spinning asbestos exposed area in eastern China
title_short	Overexpression of fibulin-3 in tumor tissue predicts poor survival of malignant mesothelioma patients from hand-spinning asbestos exposed area in eastern China
title_full	Overexpression of fibulin-3 in tumor tissue predicts poor survival of malignant mesothelioma patients from hand-spinning asbestos exposed area in eastern China
title_fullStr	Overexpression of fibulin-3 in tumor tissue predicts poor survival of malignant mesothelioma patients from hand-spinning asbestos exposed area in eastern China
title_full_unstemmed	Overexpression of fibulin-3 in tumor tissue predicts poor survival of malignant mesothelioma patients from hand-spinning asbestos exposed area in eastern China
title_sort	overexpression of fibulin-3 in tumor tissue predicts poor survival of malignant mesothelioma patients from hand-spinning asbestos exposed area in eastern china
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/581dcb45178e4732b0734e5acddf5304
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Overexpression of fibulin-3 in tumor tissue predicts poor survival of malignant mesothelioma patients from hand-spinning asbestos exposed area in eastern China

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