Evaluation of the effect of carrier material on modification of release characteristics of poor water soluble drug from liquisolid compacts.

Liquisolid compact is a novel dosage form in which a liquid medication (liquid drug, drug solution/dispersion in non-volatile solvent/solvent system) is converted to a dry, free flowing powder and compressed. Objective of the study was to elucidate the effect of carrier material on release character...

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Autores principales:	Beenish Ali, Amjad Khan, Hamad S Alyami, Majeed Ullah, Abdul Wahab, Munair Badshah, Attiqa Naz
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/58229a7a110a4942b4645e25e459aa95
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spelling	oai:doaj.org-article:58229a7a110a4942b4645e25e459aa952021-12-02T20:15:20ZEvaluation of the effect of carrier material on modification of release characteristics of poor water soluble drug from liquisolid compacts.1932-620310.1371/journal.pone.0249075https://doaj.org/article/58229a7a110a4942b4645e25e459aa952021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0249075https://doaj.org/toc/1932-6203Liquisolid compact is a novel dosage form in which a liquid medication (liquid drug, drug solution/dispersion in non-volatile solvent/solvent system) is converted to a dry, free flowing powder and compressed. Objective of the study was to elucidate the effect of carrier material on release characteristics of clopidogrel from liquisolid compacts. Different formulations of liquisolid compacts were developed using microcrystalline cellulose, starch maize, polyvinyl pyrollidone and hydroxypropyl methylcellulose as carrier material in three concentrations (40, 30 and 20%, w/w). Liquid vehicle was selected on the basis of solubility of clopidogrel. Colloidal silicondioxide was used as coating material and ratio of carrier to coating material was kept 10. A control formulation comprised of microcrystalline cellulose (diluents), tabletose-80 (diluents), primojel (disintegrant) and magnesium stearate (lubricant) was prepared by direct compression technique and was used for comparison. All the formulations were evaluated at pre and post compression level. Acid solubility profile showed higher solubility in HCl buffer pH2 (296.89±3.49 μg/mL). Mixture of propylene glycol and water (2:1, v/v) was selected as liquid vehicle. Drug content was in the range of 99-101% of the claimed quantity. All the formulations showed better mechanical strength and their friability was within the official limits (<1%). Microcrystalline cellulose and starch maize resulted in faster drug release while polyvinyl pyrollidone and HPMC resulted in sustaining drug release by gel formation. It is concluded from results that both fast release and sustained release of clopidogrel can be achieved by proper selection of carrier material.Beenish AliAmjad KhanHamad S AlyamiMajeed UllahAbdul WahabMunair BadshahAttiqa NazPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0249075 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Beenish Ali Amjad Khan Hamad S Alyami Majeed Ullah Abdul Wahab Munair Badshah Attiqa Naz Evaluation of the effect of carrier material on modification of release characteristics of poor water soluble drug from liquisolid compacts.
description	Liquisolid compact is a novel dosage form in which a liquid medication (liquid drug, drug solution/dispersion in non-volatile solvent/solvent system) is converted to a dry, free flowing powder and compressed. Objective of the study was to elucidate the effect of carrier material on release characteristics of clopidogrel from liquisolid compacts. Different formulations of liquisolid compacts were developed using microcrystalline cellulose, starch maize, polyvinyl pyrollidone and hydroxypropyl methylcellulose as carrier material in three concentrations (40, 30 and 20%, w/w). Liquid vehicle was selected on the basis of solubility of clopidogrel. Colloidal silicondioxide was used as coating material and ratio of carrier to coating material was kept 10. A control formulation comprised of microcrystalline cellulose (diluents), tabletose-80 (diluents), primojel (disintegrant) and magnesium stearate (lubricant) was prepared by direct compression technique and was used for comparison. All the formulations were evaluated at pre and post compression level. Acid solubility profile showed higher solubility in HCl buffer pH2 (296.89±3.49 μg/mL). Mixture of propylene glycol and water (2:1, v/v) was selected as liquid vehicle. Drug content was in the range of 99-101% of the claimed quantity. All the formulations showed better mechanical strength and their friability was within the official limits (<1%). Microcrystalline cellulose and starch maize resulted in faster drug release while polyvinyl pyrollidone and HPMC resulted in sustaining drug release by gel formation. It is concluded from results that both fast release and sustained release of clopidogrel can be achieved by proper selection of carrier material.
format	article
author	Beenish Ali Amjad Khan Hamad S Alyami Majeed Ullah Abdul Wahab Munair Badshah Attiqa Naz
author_facet	Beenish Ali Amjad Khan Hamad S Alyami Majeed Ullah Abdul Wahab Munair Badshah Attiqa Naz
author_sort	Beenish Ali
title	Evaluation of the effect of carrier material on modification of release characteristics of poor water soluble drug from liquisolid compacts.
title_short	Evaluation of the effect of carrier material on modification of release characteristics of poor water soluble drug from liquisolid compacts.
title_full	Evaluation of the effect of carrier material on modification of release characteristics of poor water soluble drug from liquisolid compacts.
title_fullStr	Evaluation of the effect of carrier material on modification of release characteristics of poor water soluble drug from liquisolid compacts.
title_full_unstemmed	Evaluation of the effect of carrier material on modification of release characteristics of poor water soluble drug from liquisolid compacts.
title_sort	evaluation of the effect of carrier material on modification of release characteristics of poor water soluble drug from liquisolid compacts.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/58229a7a110a4942b4645e25e459aa95
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Evaluation of the effect of carrier material on modification of release characteristics of poor water soluble drug from liquisolid compacts.

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