A large-scale multi-institutional study evaluating prognostic aspects of positive ascites cytology and effects of therapeutic interventions in epithelial ovarian cancer

Abstract Positive ascites cytology is a strong prognostic factor in patients with early-stage ovarian cancer (OvCa). However, limited information is currently available on the impact of positive ascites cytology on patient prognoses under each clinical background. We herein investigated the comprehe...

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Autores principales:	Masato Yoshihara, Ryo Emoto, Kazuhisa Kitami, Shohei Iyoshi, Kaname Uno, Kazumasa Mogi, Sho Tano, Nobuhisa Yoshikawa, Shigeyuki Matsui, Hiroaki Kajiyama
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5827c91321204f418dd2beb04af1a6b4
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spelling	oai:doaj.org-article:5827c91321204f418dd2beb04af1a6b42021-12-02T16:25:00ZA large-scale multi-institutional study evaluating prognostic aspects of positive ascites cytology and effects of therapeutic interventions in epithelial ovarian cancer10.1038/s41598-021-93718-32045-2322https://doaj.org/article/5827c91321204f418dd2beb04af1a6b42021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93718-3https://doaj.org/toc/2045-2322Abstract Positive ascites cytology is a strong prognostic factor in patients with early-stage ovarian cancer (OvCa). However, limited information is currently available on the impact of positive ascites cytology on patient prognoses under each clinical background. We herein investigated the comprehensive impact of positive ascites cytology on patients with epithelial OvCa and the effectiveness of additional therapeutic interventions, including complete staging surgery and chemotherapy. Among 4730 patients with malignant ovarian neoplasms, retrospectively identified in multiple institutions, 1906 with epithelial OvCa were included. In the investigation of its effects on clinical factors using a multivariate analysis, positive ascites cytology correlated with a poor prognosis. Positive ascites cytology had a significantly worse prognosis than those with negative cytology in all subgroups except for patients with stage IV tumors and a mucinous histology. Chemotherapy may be effective in reducing the negative impact of positive ascites cytology on the prognosis of patients in terms of progression-free and overall survivals, while complete staging surgery did not improve the prognosis of patients with positive ascites cytology. Collectively, our findings suggested that positive ascites cytology had a negative impact on the prognosis of patients with epithelial OvCa, but not those with stage IV tumors or a mucinous histology.Masato YoshiharaRyo EmotoKazuhisa KitamiShohei IyoshiKaname UnoKazumasa MogiSho TanoNobuhisa YoshikawaShigeyuki MatsuiHiroaki KajiyamaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masato Yoshihara Ryo Emoto Kazuhisa Kitami Shohei Iyoshi Kaname Uno Kazumasa Mogi Sho Tano Nobuhisa Yoshikawa Shigeyuki Matsui Hiroaki Kajiyama A large-scale multi-institutional study evaluating prognostic aspects of positive ascites cytology and effects of therapeutic interventions in epithelial ovarian cancer
description	Abstract Positive ascites cytology is a strong prognostic factor in patients with early-stage ovarian cancer (OvCa). However, limited information is currently available on the impact of positive ascites cytology on patient prognoses under each clinical background. We herein investigated the comprehensive impact of positive ascites cytology on patients with epithelial OvCa and the effectiveness of additional therapeutic interventions, including complete staging surgery and chemotherapy. Among 4730 patients with malignant ovarian neoplasms, retrospectively identified in multiple institutions, 1906 with epithelial OvCa were included. In the investigation of its effects on clinical factors using a multivariate analysis, positive ascites cytology correlated with a poor prognosis. Positive ascites cytology had a significantly worse prognosis than those with negative cytology in all subgroups except for patients with stage IV tumors and a mucinous histology. Chemotherapy may be effective in reducing the negative impact of positive ascites cytology on the prognosis of patients in terms of progression-free and overall survivals, while complete staging surgery did not improve the prognosis of patients with positive ascites cytology. Collectively, our findings suggested that positive ascites cytology had a negative impact on the prognosis of patients with epithelial OvCa, but not those with stage IV tumors or a mucinous histology.
format	article
author	Masato Yoshihara Ryo Emoto Kazuhisa Kitami Shohei Iyoshi Kaname Uno Kazumasa Mogi Sho Tano Nobuhisa Yoshikawa Shigeyuki Matsui Hiroaki Kajiyama
author_facet	Masato Yoshihara Ryo Emoto Kazuhisa Kitami Shohei Iyoshi Kaname Uno Kazumasa Mogi Sho Tano Nobuhisa Yoshikawa Shigeyuki Matsui Hiroaki Kajiyama
author_sort	Masato Yoshihara
title	A large-scale multi-institutional study evaluating prognostic aspects of positive ascites cytology and effects of therapeutic interventions in epithelial ovarian cancer
title_short	A large-scale multi-institutional study evaluating prognostic aspects of positive ascites cytology and effects of therapeutic interventions in epithelial ovarian cancer
title_full	A large-scale multi-institutional study evaluating prognostic aspects of positive ascites cytology and effects of therapeutic interventions in epithelial ovarian cancer
title_fullStr	A large-scale multi-institutional study evaluating prognostic aspects of positive ascites cytology and effects of therapeutic interventions in epithelial ovarian cancer
title_full_unstemmed	A large-scale multi-institutional study evaluating prognostic aspects of positive ascites cytology and effects of therapeutic interventions in epithelial ovarian cancer
title_sort	large-scale multi-institutional study evaluating prognostic aspects of positive ascites cytology and effects of therapeutic interventions in epithelial ovarian cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5827c91321204f418dd2beb04af1a6b4
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A large-scale multi-institutional study evaluating prognostic aspects of positive ascites cytology and effects of therapeutic interventions in epithelial ovarian cancer

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