Tumor apelin and obesity are associated with reduced neoadjuvant chemotherapy response in a cohort of breast cancer patients

Abstract Obesity is a known factor increasing the risk of developing breast cancer and reducing disease free survival. In addition to these well-documented effects, recent studies have shown that obesity is also affecting response to chemotherapy. Among the multiple dysregulations associated with ob...

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Autores principales:	Florian Gourgue, Françoise Derouane, Cedric van Marcke, Elodie Villar, Helene Dano, Lieven Desmet, Caroline Bouzin, Francois P. Duhoux, Patrice D. Cani, Bénédicte F. Jordan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/582848c913f2403492804f339a90a0ea
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spelling	oai:doaj.org-article:582848c913f2403492804f339a90a0ea2021-12-02T16:57:26ZTumor apelin and obesity are associated with reduced neoadjuvant chemotherapy response in a cohort of breast cancer patients10.1038/s41598-021-89385-z2045-2322https://doaj.org/article/582848c913f2403492804f339a90a0ea2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89385-zhttps://doaj.org/toc/2045-2322Abstract Obesity is a known factor increasing the risk of developing breast cancer and reducing disease free survival. In addition to these well-documented effects, recent studies have shown that obesity is also affecting response to chemotherapy. Among the multiple dysregulations associated with obesity, increased level of the apelin adipokine has been recently shown to be directly involved in the association between obesity and increased breast cancer progression. In this study, we analyzed in a retrospective cohort of 62 breast cancer patients the impact of obesity and tumoral apelin expression on response to neoadjuvant chemotherapy. In the multivariate logistic regression, obesity and high tumoral apelin expression were associated with a reduced response to NAC in our cohort. However, obesity and high tumoral apelin expression were not correlated, suggesting that those two parameters could be independently associated with reduced NAC response. These findings should be confirmed in independent cohorts.Florian GourgueFrançoise DerouaneCedric van MarckeElodie VillarHelene DanoLieven DesmetCaroline BouzinFrancois P. DuhouxPatrice D. CaniBénédicte F. JordanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Florian Gourgue Françoise Derouane Cedric van Marcke Elodie Villar Helene Dano Lieven Desmet Caroline Bouzin Francois P. Duhoux Patrice D. Cani Bénédicte F. Jordan Tumor apelin and obesity are associated with reduced neoadjuvant chemotherapy response in a cohort of breast cancer patients
description	Abstract Obesity is a known factor increasing the risk of developing breast cancer and reducing disease free survival. In addition to these well-documented effects, recent studies have shown that obesity is also affecting response to chemotherapy. Among the multiple dysregulations associated with obesity, increased level of the apelin adipokine has been recently shown to be directly involved in the association between obesity and increased breast cancer progression. In this study, we analyzed in a retrospective cohort of 62 breast cancer patients the impact of obesity and tumoral apelin expression on response to neoadjuvant chemotherapy. In the multivariate logistic regression, obesity and high tumoral apelin expression were associated with a reduced response to NAC in our cohort. However, obesity and high tumoral apelin expression were not correlated, suggesting that those two parameters could be independently associated with reduced NAC response. These findings should be confirmed in independent cohorts.
format	article
author	Florian Gourgue Françoise Derouane Cedric van Marcke Elodie Villar Helene Dano Lieven Desmet Caroline Bouzin Francois P. Duhoux Patrice D. Cani Bénédicte F. Jordan
author_facet	Florian Gourgue Françoise Derouane Cedric van Marcke Elodie Villar Helene Dano Lieven Desmet Caroline Bouzin Francois P. Duhoux Patrice D. Cani Bénédicte F. Jordan
author_sort	Florian Gourgue
title	Tumor apelin and obesity are associated with reduced neoadjuvant chemotherapy response in a cohort of breast cancer patients
title_short	Tumor apelin and obesity are associated with reduced neoadjuvant chemotherapy response in a cohort of breast cancer patients
title_full	Tumor apelin and obesity are associated with reduced neoadjuvant chemotherapy response in a cohort of breast cancer patients
title_fullStr	Tumor apelin and obesity are associated with reduced neoadjuvant chemotherapy response in a cohort of breast cancer patients
title_full_unstemmed	Tumor apelin and obesity are associated with reduced neoadjuvant chemotherapy response in a cohort of breast cancer patients
title_sort	tumor apelin and obesity are associated with reduced neoadjuvant chemotherapy response in a cohort of breast cancer patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/582848c913f2403492804f339a90a0ea
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Tumor apelin and obesity are associated with reduced neoadjuvant chemotherapy response in a cohort of breast cancer patients

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